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Volumn 58, Issue 12, 2008, Pages 3637-3639

Signaling in response to hypoxia and normoxia in the intervertebral disc

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN FIBRIL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; PROTEOGLYCAN; VASCULOTROPIN;

EID: 57349174991     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24071     Document Type: Editorial
Times cited : (16)

References (39)
  • 1
    • 57349140878 scopus 로고    scopus 로고
    • United States Bone and Joint Decade. The burden of musculoskeletal diseases in the United States. Rosemont (IL): American Academy of Orthopaedic Surgeons; 2008. p 32.
    • United States Bone and Joint Decade. The burden of musculoskeletal diseases in the United States. Rosemont (IL): American Academy of Orthopaedic Surgeons; 2008. p 32.
  • 3
    • 0035890099 scopus 로고    scopus 로고
    • Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells
    • Okuda S, Myoui A, Ariga K, Nakase T, Yonenobu K, Yoshikawa H. Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells. Spine 2000;26:2421-6.
    • (2000) Spine , vol.26 , pp. 2421-2426
    • Okuda, S.1    Myoui, A.2    Ariga, K.3    Nakase, T.4    Yonenobu, K.5    Yoshikawa, H.6
  • 4
    • 0036841306 scopus 로고    scopus 로고
    • Hyperosmotically induced volume change and calcium signaling in intervertebral disk cells: The role of the actin cytoskeleton
    • Pritchard S, Erickson GR, Guilak F. Hyperosmotically induced volume change and calcium signaling in intervertebral disk cells: the role of the actin cytoskeleton. Biophys J 2002;83:2502-10.
    • (2002) Biophys J , vol.83 , pp. 2502-2510
    • Pritchard, S.1    Erickson, G.R.2    Guilak, F.3
  • 5
    • 18244364365 scopus 로고    scopus 로고
    • Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal
    • Risbud MV, Fertala J, Vresilovic EJ, Albert TJ, Shapiro IM. Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. Spine 2005;30:882-9.
    • (2005) Spine , vol.30 , pp. 882-889
    • Risbud, M.V.1    Fertala, J.2    Vresilovic, E.J.3    Albert, T.J.4    Shapiro, I.M.5
  • 7
    • 27944471389 scopus 로고    scopus 로고
    • Hypoxia activates MAPK activity in rat nucleus pulposus cells: Regulation of integrin expression and cell survival
    • Risbud MV, Guttapalli A, Albert TJ, Shapiro IM. Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival. Spine 2005;30:2503-9.
    • (2005) Spine , vol.30 , pp. 2503-2509
    • Risbud, M.V.1    Guttapalli, A.2    Albert, T.J.3    Shapiro, I.M.4
  • 8
    • 33748518936 scopus 로고    scopus 로고
    • Molecular therapy of the intervertebral disc
    • Yoon ST, Patel NM. Molecular therapy of the intervertebral disc. Eur Spine J 2006;15 Suppl 3:S379-88.
    • (2006) Eur Spine J , vol.15 , Issue.SUPPL. 3
    • Yoon, S.T.1    Patel, N.M.2
  • 9
    • 33749445416 scopus 로고    scopus 로고
    • Differential regulation of matrix degrading enzymes in a TNFα-induced model of nucleus pulposus tissue degeneration
    • Seguin CA, Bojarski M, Pilliar RM, Roughley PJ, Kandel RA. Differential regulation of matrix degrading enzymes in a TNFα-induced model of nucleus pulposus tissue degeneration. Matrix Biol 2006;25:409-18.
    • (2006) Matrix Biol , vol.25 , pp. 409-418
    • Seguin, C.A.1    Bojarski, M.2    Pilliar, R.M.3    Roughley, P.J.4    Kandel, R.A.5
  • 10
    • 38749098170 scopus 로고    scopus 로고
    • Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling
    • Uchiyama Y, Cheng CC, Danielson KG, Mochida J, Albert TJ, Shapiro IM, et al. Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling. J Bone Miner Res 2007;22:1996-2006.
    • (2007) J Bone Miner Res , vol.22 , pp. 1996-2006
    • Uchiyama, Y.1    Cheng, C.C.2    Danielson, K.G.3    Mochida, J.4    Albert, T.J.5    Shapiro, I.M.6
  • 11
    • 36148934197 scopus 로고    scopus 로고
    • PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways
    • Pratsinis H, Kletsas D. PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways. Eur Spine J 2007;16:1858-66.
    • (2007) Eur Spine J , vol.16 , pp. 1858-1866
    • Pratsinis, H.1    Kletsas, D.2
  • 12
    • 33947181438 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: Implications for cell-based transplantation therapy
    • Tsai TT, Guttapalli A, Oguz E, Chen LH, Vaccaro AR, Albert TJ, et al. Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: implications for cell-based transplantation therapy. Spine 2007;32:495-502.
    • (2007) Spine , vol.32 , pp. 495-502
    • Tsai, T.T.1    Guttapalli, A.2    Oguz, E.3    Chen, L.H.4    Vaccaro, A.R.5    Albert, T.J.6
  • 13
    • 34548546827 scopus 로고    scopus 로고
    • Tsai TT, Guttapalli A, Agrawal A, Albert TJ, Shapiro IM, Risbud MV. MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP. J Bone Miner Res 2007;22:965-74.
    • Tsai TT, Guttapalli A, Agrawal A, Albert TJ, Shapiro IM, Risbud MV. MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP. J Bone Miner Res 2007;22:965-74.
  • 14
    • 39049119345 scopus 로고    scopus 로고
    • p38 MAPK inhibition in nucleus pulposus cells: A potential target for treating intervertebral disc degeneration
    • Studer RK, Aboka AM, Gilbertson LG, Georgescu H, Sowa G, Vo N, et al. p38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration. Spine 2007;32:2827-33.
    • (2007) Spine , vol.32 , pp. 2827-2833
    • Studer, R.K.1    Aboka, A.M.2    Gilbertson, L.G.3    Georgescu, H.4    Sowa, G.5    Vo, N.6
  • 15
    • 39649087811 scopus 로고    scopus 로고
    • The occurrence and regional distribution of DR4 on herniated disc cells: A potential apoptosis pathway in lumbar intervertebral disc
    • Zhang L, Niu T, Yang SY, Lu Z, Chen B. The occurrence and regional distribution of DR4 on herniated disc cells: a potential apoptosis pathway in lumbar intervertebral disc. Spine 2008;33:422-7.
    • (2008) Spine , vol.33 , pp. 422-427
    • Zhang, L.1    Niu, T.2    Yang, S.Y.3    Lu, Z.4    Chen, B.5
  • 16
    • 39649114343 scopus 로고    scopus 로고
    • TNF-α induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration
    • Seguin CA, Pilliar RM, Madri JA, Kandel RA. TNF-α induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration. Spine 2008;33:356-65.
    • (2008) Spine , vol.33 , pp. 356-365
    • Seguin, C.A.1    Pilliar, R.M.2    Madri, J.A.3    Kandel, R.A.4
  • 18
    • 44649175659 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc
    • Fujita N, Imai J, Suzuki T, Yamada M, Ninomiya K, Miyamoto K, et al. Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc. Biochem Biophys Res Commun 2008;372:367-72.
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 367-372
    • Fujita, N.1    Imai, J.2    Suzuki, T.3    Yamada, M.4    Ninomiya, K.5    Miyamoto, K.6
  • 19
    • 0036865325 scopus 로고    scopus 로고
    • Disc morphology in health and disease
    • Roberts S. Disc morphology in health and disease. Biochem Soc Trans 2002;30:864-9.
    • (2002) Biochem Soc Trans , vol.30 , pp. 864-869
    • Roberts, S.1
  • 20
    • 38349177151 scopus 로고    scopus 로고
    • Intervertebral disc: Anatomy-physiology-pathophysiology-treatment [review]
    • Raj PP. Intervertebral disc: anatomy-physiology-pathophysiology-treatment [review]. Pain Pract 2008;8:18-44.
    • (2008) Pain Pract , vol.8 , pp. 18-44
    • Raj, P.P.1
  • 21
    • 0016752270 scopus 로고
    • Factors involved in the nutrition of the human lumbar intervertebral disc: Cellularity and diffusion of glucose in vitro
    • Maroudas A, Stockwell RA, Nachemson A, Urban J. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J Anat 1975;120:113-30.
    • (1975) J Anat , vol.120 , pp. 113-130
    • Maroudas, A.1    Stockwell, R.A.2    Nachemson, A.3    Urban, J.4
  • 22
    • 14344255879 scopus 로고    scopus 로고
    • Metabolism of the intervertebral disc: Effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells
    • Bibby SR, Jones DA, Ripley RM, Urban JP. Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells. Spine 2005;30:487-96.
    • (2005) Spine , vol.30 , pp. 487-496
    • Bibby, S.R.1    Jones, D.A.2    Ripley, R.M.3    Urban, J.P.4
  • 23
    • 0035989142 scopus 로고    scopus 로고
    • Phenotypic characteristics of the nucleus pulposus: Expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2
    • Rajpurohit R, Risbud MV, Ducheyne P, Vresilovic EJ, Shapiro IM. Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell Tissue Res 2002;308:401-7.
    • (2002) Cell Tissue Res , vol.308 , pp. 401-407
    • Rajpurohit, R.1    Risbud, M.V.2    Ducheyne, P.3    Vresilovic, E.J.4    Shapiro, I.M.5
  • 24
    • 34547763695 scopus 로고    scopus 로고
    • Normoxic stabilization of HIF-1α drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk
    • Agrawal A, Guttapalli A, Narayan S, Albert TJ, Shapiro IM, Risbud MV. Normoxic stabilization of HIF-1α drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. Am J Physiol Cell Physiol 2007;293:C621-31.
    • (2007) Am J Physiol Cell Physiol , vol.293
    • Agrawal, A.1    Guttapalli, A.2    Narayan, S.3    Albert, T.J.4    Shapiro, I.M.5    Risbud, M.V.6
  • 27
    • 25144514862 scopus 로고    scopus 로고
    • Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: Involvement of HIF-1α in the pathogenesis of osteoarthritis
    • Yudoh K, Nakamura H, Masuko-Hongo K, Kato T, Nishioka K. Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis. Arthritis Res Ther 2005;7:R904-14.
    • (2005) Arthritis Res Ther , vol.7
    • Yudoh, K.1    Nakamura, H.2    Masuko-Hongo, K.3    Kato, T.4    Nishioka, K.5
  • 29
    • 57349102342 scopus 로고    scopus 로고
    • Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc
    • Agrawal A, Gajghate S, Smith H, Anderson DG, Albert TJ, Shapiro IM, et al. Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc. Arthritis Rheum 2008;58:3798-808.
    • (2008) Arthritis Rheum , vol.58 , pp. 3798-3808
    • Agrawal, A.1    Gajghate, S.2    Smith, H.3    Anderson, D.G.4    Albert, T.J.5    Shapiro, I.M.6
  • 30
    • 4143110440 scopus 로고    scopus 로고
    • HIF-1: Master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs
    • Mazure NM, Brahimi-Horn MC, Berta MA, Benizri E, Bilton RL, Dayan F, et al. HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs. Biochem Pharmacol 2004;68:971-80.
    • (2004) Biochem Pharmacol , vol.68 , pp. 971-980
    • Mazure, N.M.1    Brahimi-Horn, M.C.2    Berta, M.A.3    Benizri, E.4    Bilton, R.L.5    Dayan, F.6
  • 31
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-54.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 32
    • 0031825702 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: From molecular biology to cardiopulmonary physiology
    • Semenza GL, Agani F, Iyer N, Jiang BH, Leung S, Wiener C, et al. Hypoxia-inducible factor 1: from molecular biology to cardiopulmonary physiology. Chest 1998;114(1 Suppl):40-5S.
    • (1998) Chest , vol.114 , Issue.1 SUPPL.
    • Semenza, G.L.1    Agani, F.2    Iyer, N.3    Jiang, B.H.4    Leung, S.5    Wiener, C.6
  • 33
    • 0030200804 scopus 로고    scopus 로고
    • Transcriptional regulation by hypoxia-inducible factor 1: Molecular mechanisms of oxygen homeostasis
    • Semenza GL. Transcriptional regulation by hypoxia-inducible factor 1: molecular mechanisms of oxygen homeostasis. Trends Cardiovasc Med 1996;6:151-7.
    • (1996) Trends Cardiovasc Med , vol.6 , pp. 151-157
    • Semenza, G.L.1
  • 35
    • 0036679122 scopus 로고    scopus 로고
    • The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation
    • Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, et al. The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation. Proc Natl Acad Sci U S A 2002;99:10488-93.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10488-10493
    • Yin, Z.1    Haynie, J.2    Yang, X.3    Han, B.4    Kiatchoosakun, S.5    Restivo, J.6
  • 36
    • 34250163609 scopus 로고    scopus 로고
    • Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia
    • Van den Beucken T, Magagnin MG, Savelkouls K, Lambin P, Koritzinsky M, Wouters BG. Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia. Radiother Oncol 2007;83:346-52.
    • (2007) Radiother Oncol , vol.83 , pp. 346-352
    • Van den Beucken, T.1    Magagnin, M.G.2    Savelkouls, K.3    Lambin, P.4    Koritzinsky, M.5    Wouters, B.G.6
  • 37
    • 35848938945 scopus 로고    scopus 로고
    • The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α
    • Hu CJ, Sataur A, Wang L, Chen H, Simon MC. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α. Mol Biol Cell 2007;18:4528-42.
    • (2007) Mol Biol Cell , vol.18 , pp. 4528-4542
    • Hu, C.J.1    Sataur, A.2    Wang, L.3    Chen, H.4    Simon, M.C.5
  • 38
    • 33646010313 scopus 로고    scopus 로고
    • Nucleus pulposus cells express HIF-1α under normoxic culture conditions: A metabolic adaptation to the intervertebral disc microenvironment
    • Risbud MV, Guttapalli A, Stokes DG, Hawkins D, Danielson KG, Schaer TP, et al. Nucleus pulposus cells express HIF-1α under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J Cell Biochem 2006;98:152-9.
    • (2006) J Cell Biochem , vol.98 , pp. 152-159
    • Risbud, M.V.1    Guttapalli, A.2    Stokes, D.G.3    Hawkins, D.4    Danielson, K.G.5    Schaer, T.P.6
  • 39
    • 50949113918 scopus 로고    scopus 로고
    • HIF-1α: A key survival factor for serum-deprived prostate cancer cells
    • Thomas R, Kim MH. HIF-1α: a key survival factor for serum-deprived prostate cancer cells. Prostate 2008;68:1405-15.
    • (2008) Prostate , vol.68 , pp. 1405-1415
    • Thomas, R.1    Kim, M.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.