TNF-α induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration

Spine

Volumn 33, Issue 4, 2008, Pages 356-365

  Séguin, Cheryle A ^a,d   Pilliar, Robert M ^a,b   Madri, Joseph A ^c   Kandel, Rita A ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Egr 1; ERK MAPK; MMP 2; MT1 MMP; Nucleus pulposus; TNF

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; GELATINASE A; LUCIFERASE; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA BINDING; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; GENE ACTIVITY; GENE EXPRESSION; IMMUNOBLOTTING; IN VITRO STUDY; INTERVERTEBRAL DISK; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE DEGENERATION; UPREGULATION;

EID: 39649114343     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181642a5e     Document Type: Article

References (60)

1. Bogduk N. The inter-body joints and the intervertebral discs. In: Bogduk N, ed. Clinical Anatomy of the Lumbar Spine and Sacrum. New York: Churchill Livingstone; 1997:13-31.
2. Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine 2006;31:2151-61.
3. Ahn SH, Cho YW, Ahn MW, et al. mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs. Spine 2002;27:911-17.
4. Burke JG, Watson RW, McCormack D, et al. Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral disc. Spine 2002;27:1402-7.
5. Burke JG, Watson RW, McCormack D, et al. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 2002;84:196-201.
6. Kang JD, Georgescu HI, McIntyre-Larkin L, et al. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine 1996;21:271-7.
7. Olmarker K, Larsson K. Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury. Spine 1998;23:2538-44.
8. Rand N, Reichert F, Floman Y, et al. Murine nucleus pulposus-derived cells secrete interleukins-1-beta, -6, and -10 and granulocyte-macrophage colony-stimulating factor in cell culture. Spine 1997;22:2598-601.
9. Takahashi H, Suguro T, Okazima Y, et al. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine 1996;21:218-24.
10. Yoshida M, Nakamura T, Sei A, et al. Intervertebral disc cells produce tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 immediately after herniation: an experimental study using a new hernia model. Spine 2005;30:55-61.
11. Weiler C, Nerlich AG, Bachmeier BE, et al. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 2005;30:44-53.
12. Bachmeier BE, Nerlich AG, Weiler C, et al. Analysis of tissue distribution of TNF-alpha, TNF-alpha-receptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc. Ann N Y Acad Sci 2007;1096:44-54.
13. Roberts S, Evans H, Menage J, et al. TNFalpha-stimulated gene product (TSG-6) and its binding protein, IalphaI, in the human intervertebral disc: new molecules for the disc. Eur Spine J 2005;14:36-42.
14. Igarashi T, Kikuchi S, Shubayev V, et al. 2000 Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine 2000;25:2975-80.
15. Olmarker K, Rydevik B. Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica. Spine 2001;26:863-9.
16. Wagner R, Myers RR. Endoneurial injection of TNF-alpha produces neuropathic pain behaviors. Neuroreport 1996;7:2897-901.
17. Imai K, Ohuchi E, Aoki T, et al. Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2. Cancer Res 1996;56:2707-10.
18. Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 1994;370:61-5.
19. Rajpurohit R, Risbud MV, Ducheyne P, et al. Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell Tissue Res 2002;308:401-7.
20. Weiler C, Nerlich AG, Zipperer J, et al. 2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur Spine J 2002;11:308-20.
21. Pattison ST, Melrose J, Ghosh P, et al. Regulation of gelatinase-A (MMP-2) production by ovine intervertebral disc nucleus pulposus cells grown in alginate bead culture by transforming growth factor-beta(1)and insulin like growth factor-I. Cell Biol Int 2001;25:679-89.
22. Risbud MV, Izzo MW, Adams CS, et al. An organ culture system for the study of the nucleus pulposus: description of the system and evaluation of the cells. Spine 2003;28:2652-8.
23. Sakuma M, Fujii N, Takahashi T, et al. Effect of chondroitinase ABC on matrix metalloproteinases and inflammatory mediators produced by intervertebral disc of rabbit in vitro. Spine 2002;27:576-80.
24. Seguin CA, Pilliar RM, Roughley PJ, et al. Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine 2005;30:1940-8.
25. Crean JK, Roberts S, Jaffray DC, et al. Matrix metalloproteinases in the human intervertebral disc: role in disc degeneration and scoliosis. Spine 1997;22:2877-84.
26. Hsieh AH, Lotz JC. Prolonged spinal loading induces matrix metalloproteinase-2 activation in intervertebral discs. Spine 2003;28:1781-8.
27. Carreon LY, Ito T, Yamada M, et al. Neovascularization induced by anulus and its inhibition by cartilage endplate. Its role in disc absorption. Spine 1997;22:1429-34.
28. Pilliar RM, Filiaggi MJ, Wells JD, et al. Porous calcium polyphosphate scaffolds for bone substitute applications - in vitro characterization. Biomaterials 2001;22:963-72.
29. Seguin CA, Grynpas MD, Pilliar RM, et al. Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrate. Spine 2004;29:1299-306.
30. Heussen C, Dowdle EB. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem 1980;102:196-202.
31. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983;11:1475-89.
32. Haas TL, Stitelman D, Davis SJ, et al. Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium. J Biol Chem 1999;274:22679-85.
33. Seguin CA, Bojarski M, Pilliar RM, et al. Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration. Matrix Biol 2006;25:409-18.
34. Kaufmann K, Thiel G. Epidermal growth factor and platelet-derived growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells. J Neurol Sci 2001;189:83-91.
35. Boyd PJ, Doyle J, Gee E, et al. MAPK signaling regulates endothelial cell assembly into networks and expression of MT1-MMP and MMP-2. Am J Physiol Cell Physiol 2005;288:C659-C668.
36. Schwachtgen JL, Houston P, Campbell C, et al. Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway. J Clin Invest 1998;101:2540-9.
37. Guha M, O'Connell MA, Pawlinski R, et al. Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood 2001;98:1429-39.
38. Chen CC, Lee WR, Safe S. Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. J Cell Biochem 2004;93:1063-74.
39. Schaefer A, Kosa F, Bittorf T, et al. Opposite effects of inhibitors of mitogen-activated protein kinase pathways on the egr-1 and beta-globin expression in erythropoietin-responsive murine erythroleukemia cells. Cell Signal 2004;16:223-34.
40. Clarkson RW, Shang CA, Levitt LK, et al. Ternary complex factors Elk-1 and Sap-1a mediate growth hormone-induced transcription of egr-1 (early growth response factor-1) in 3T3-F442A preadipocytes. Mol Endocrinol 1999;13:619-31.
41. Schwachtgen JL, Campbell CJ, Braddock M. Full promoter sequence of human early growth response factor-1 (Egr-1): demonstration of a fifth functional serum response element. DNA Seq 2000;10:429-32.
42. Waters CM, Hancock DC, Evan GI. Identification and characterisation of the egr-1 gene product as an inducible, short-lived, nuclear phosphoprotein. Oncogene 1990;5:669-74.
43. Cao XM, Guy GR, Sukhatme VP, et al. Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts. J Biol Chem 1992;267:1345-9.
44. Goetze S, Kintscher U, Kaneshiro K, et al. TNFalpha induces expression of transcription factors c-fos, Egr-1, and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2. Atherosclerosis 2001;159:93-101.
45. Nguyen HQ, Hoffman-Liebermann B, Liebermann DA. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 1993;72:197-209.
46. McMahon AP, Champion JE, McMahon JA, et al. Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues. Development 1990;108:281-7.
47. Tan L, Peng H, Osaki M, et al. Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta. J Biol Chem 2003;278:17688-700.
48. Aicher WK, Heer AH, Trabandt A, et al. Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients. J Immunol 1994;152:5940-8.
49. Wang FL, Connor JR, Dodds RA, et al. Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage. Osteoarthr Cartil 2000;8:161-9.
50. Itoh Y, Seiki M. MT1-MMP: a potent modifier of pericellular microenvironment. J Cell Physiol 2006;206:1-8.
51. Itoh Y, Seiki M. MT1-MMP: an enzyme with multidimensional regulation. Trends Biochem Sci 2004;29:285-9.
52. Lohi J, Lehti K, Valtanen H, et al. Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene. Gene 2000;242:75-86.
53. Alfonso-Jaume MA, Mahimkar R, Lovett DH. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Biochem J 2004;380:735-47.
54. Yamaguchi S, Yamaguchi M, Yatsuyanagi E, et al. Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium. Lab Invest 2002;82:949-56.
55. Khachigian LM, Lindner V, Williams AJ, et al. Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 1996;271:1427-31.
56. Zhang B, Yan L, Tsang PC, et al. Matrix metalloproteinase-2 (MMP-2) expression and regulation by tumor necrosis factor alpha (TNFalpha) in the bovine corpus luteum. Mol Reprod Dev 2005;70:122-32.
57. Wang BW, Chang H, Lin S, et al. Induction of matrix metalloproteinases-14 and -2 by cyclical mechanical stretch is mediated by tumor necrosis factor-alpha in cultured human umbilical vein endothelial cells. Cardiovasc Res 2003;59:460-9.
58. Lu KV, Jong KA, Rajasekaran AK, et al. Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line. Lab Invest 2004;84:8-20.
59. Han YP, Tuan TL, Wu H, et al. TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. J Cell Sci 2001;114:131-9.
60. Buttner FH, Hughes CE, Margerie D, et al. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan. Biochem J 1998;333(pt 1):159-65.