Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)

Drug Metabolism and Disposition

Volumn 36, Issue 12, 2008, Pages 2571-2581

  Grant, Caroline E ^a   Gao, Mian ^a,b   DeGorter, Marianne K ^a,c   Cole, Susan P C ^a   Deeley, Roger G ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b BRISTOL MYERS SQUIBB   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; ESTRADIOL 17 GLUCURONIDE; ESTRONE SULFATE; ETOPOSIDE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 3; SULFUR 35; TRITIUM; VINCRISTINE;

ARTICLE; CELL STRAIN HEK293; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG RESISTANCE; DRUG TRANSPORT; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEMBRANE VESICLE; MICHAELIS MENTEN KINETICS; MUTATIONAL ANALYSIS; PHOTOAFFINITY LABELING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ESTRADIOL; ESTRONE; ETOPOSIDE; GLUTATHIONE; HUMANS; KINETICS; LEUKOTRIENE C4; METHOTREXATE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION; VINCRISTINE;

EID: 57349152178     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.022491     Document Type: Article

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