Anchoring effects in a wide binding pocket: The molecular basis of regioselectivity in engineered cytochrome P450 monooxygenase from B. megaterium

Proteins: Structure, Function and Genetics

Volumn 73, Issue 3, 2008, Pages 597-607

  Branco, Ricardo J F ^a   Seifert, Alexander ^b   Budde, Michael ^b   Urlacher, Vlada B ^b   Ramos, Maria J ^a   Pleiss, Jürgen ^b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF STUTTGART   (Germany)

Author keywords

CYP102A1 monooxygenase; Molecular dynamics simulation; Mutants; Pinene

Indexed keywords

BETA PINENE; CYTOCHROME P450; CYTOCHROME P450 BM3; MUTANT PROTEIN; MYRTANAL; MYRTENOL; PINENE; PINENE OXIDE; PINOCARVEOL; PLANT MEDICINAL PRODUCT; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; VERBENOL;

ARTICLE; BACILLUS MEGATERIUM; CHEMICAL REACTION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING;

BACILLUS MEGATERIUM; BICYCLO COMPOUNDS; CATALYTIC DOMAIN; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONOTERPENES; MUTANT PROTEINS; OXIDATION-REDUCTION; PROTEIN ENGINEERING; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

BACILLUS MEGATERIUM;

EID: 57349146611     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22083     Document Type: Article

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