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Volumn 24, Issue 6, 2008, Pages 381-386

Immunologic pathogenesis of multiple sclerosis

Author keywords

Immunology; Multiple sclerosis; Pathogenesis

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; BETA INTERFERON; CLADRIBINE; CYCLOPHOSPHAMIDE; FAS ANTIGEN; FAS LIGAND; GLATIRAMER; INTERLEUKIN 16; METHOTREXATE; MYELIN; MYELIN BASIC PROTEIN;

EID: 57349130471     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-008-2429-8     Document Type: Short Survey
Times cited : (10)

References (45)
  • 1
    • 0024368359 scopus 로고
    • Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
    • D.G. Ando J. Clayton D. Kono J.L. Urban E.E. Sercarz 1989 Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype Cell Immunol 124 132 143
    • (1989) Cell Immunol , vol.124 , pp. 132-143
    • Ando, D.G.1    Clayton, J.2    Kono, D.3    Urban, J.L.4    Sercarz, E.E.5
  • 2
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    • E.S. Huseby D. Liggitt T. Brabb B. Schnabel C. Ohlén J. Goverman 2001 A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis J Exp Med 194 669 676
    • (2001) J Exp Med , vol.194 , pp. 669-676
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlén, C.5    Goverman, J.6
  • 3
    • 2542418993 scopus 로고    scopus 로고
    • High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay
    • M.P. Crawford S.X. Yan S.B. Ortega R.S. Mehta R.E. Hewitt D.A. Price 2004 High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay Blood 103 4222 4231
    • (2004) Blood , vol.103 , pp. 4222-4231
    • Crawford, M.P.1    Yan, S.X.2    Ortega, S.B.3    Mehta, R.S.4    Hewitt, R.E.5    Price, D.A.6
  • 4
    • 0031933496 scopus 로고    scopus 로고
    • The cytokine storm in multiple sclerosis
    • H. Link 1998 The cytokine storm in multiple sclerosis Mult Scler 4 12 15
    • (1998) Mult Scler , vol.4 , pp. 12-15
    • Link, H.1
  • 5
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses
    • G. Trinchieri S. Pflanz R.A. Kastelein 2003 The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses Immunity 19 641 644
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1    Pflanz, S.2    Kastelein, R.A.3
  • 6
    • 35649000947 scopus 로고    scopus 로고
    • IL-12/IFN-γ/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis
    • B.G. Xiao C.G. Ma L.Y. Xu H. Link C.Z. Lu 2008 IL-12/IFN-γ/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis Mol Immunol 45 1191 1196
    • (2008) Mol Immunol , vol.45 , pp. 1191-1196
    • Xiao, B.G.1    Ma, C.G.2    Xu, L.Y.3    Link, H.4    Lu, C.Z.5
  • 7
    • 51249090471 scopus 로고    scopus 로고
    • T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
    • C.J. Hedegaard M. Krakauer K. Bendtzen H. Lund F. Sellebjerg C.H. Nielsen 2008 T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis Immunology 125 161 169
    • (2008) Immunology , vol.125 , pp. 161-169
    • Hedegaard, C.J.1    Krakauer, M.2    Bendtzen, K.3    Lund, H.4    Sellebjerg, F.5    Nielsen, C.H.6
  • 8
    • 25144520110 scopus 로고    scopus 로고
    • Characterizing the mechanisms of progression in multiple sclerosis: Evidence and new hypotheses for future directions
    • E.M. Frohman M. Filippi O. Stuve S.G. Waxman J. Corboy J.T. Phillips 2005 Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions Arch Neurol 62 1345 1356
    • (2005) Arch Neurol , vol.62 , pp. 1345-1356
    • Frohman, E.M.1    Filippi, M.2    Stuve, O.3    Waxman, S.G.4    Corboy, J.5    Phillips, J.T.6
  • 9
    • 0032525044 scopus 로고    scopus 로고
    • A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice
    • M. Falcone A.J. Rajan B.R. Bloom C.F. Brosnan 1998 A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice J Immunol 160 4822 4830
    • (1998) J Immunol , vol.160 , pp. 4822-4830
    • Falcone, M.1    Rajan, A.J.2    Bloom, B.R.3    Brosnan, C.F.4
  • 10
    • 0032193696 scopus 로고    scopus 로고
    • IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10 and IL-4 deficient and transgenic mice
    • E. Bettelli M.P. Das E.D. Howard H.L. Weiner R.A. Sobel V.K. Kuchroo 1998 IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10 and IL-4 deficient and transgenic mice J Immunol 161 3299 3306
    • (1998) J Immunol , vol.161 , pp. 3299-3306
    • Bettelli, E.1    Das, M.P.2    Howard, E.D.3    Weiner, H.L.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 11
    • 0037406714 scopus 로고    scopus 로고
    • Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells
    • P.L. Vieira H.C. Heystek J. Wormmeester E.A. Wierenga M.L. Kapsenberg 2003 Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells J Immunol 170 4483 4488
    • (2003) J Immunol , vol.170 , pp. 4483-4488
    • Vieira, P.L.1    Heystek, H.C.2    Wormmeester, J.3    Wierenga, E.A.4    Kapsenberg, M.L.5
  • 12
    • 0242468114 scopus 로고    scopus 로고
    • IL-5 deficient mice are susceptible to experimental autoimmune encephlomyelitis
    • C. Weir C.C. Bernard B.T. Backstrom 2003 IL-5 deficient mice are susceptible to experimental autoimmune encephlomyelitis Int Immunol 15 1283 1289
    • (2003) Int Immunol , vol.15 , pp. 1283-1289
    • Weir, C.1    Bernard, C.C.2    Backstrom, B.T.3
  • 13
    • 0028960035 scopus 로고
    • Cytokines and murine autoimmune encephalomyelitis: Inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system
    • D.O. Willenborg S.A. Fordham W.B. Cowden I.A. Ramshaw 1995 Cytokines and murine autoimmune encephalomyelitis: Inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system Scand J Immunol 41 31 41
    • (1995) Scand J Immunol , vol.41 , pp. 31-41
    • Willenborg, D.O.1    Fordham, S.A.2    Cowden, W.B.3    Ramshaw, I.A.4
  • 15
    • 48249148236 scopus 로고    scopus 로고
    • IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
    • S. Serada M. Fujimoto M. Mihara N. Koike Y. Ohsugi S. Nomura 2008 IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis Proc Natl Acad Sci 105 9041 9046
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 9041-9046
    • Serada, S.1    Fujimoto, M.2    Mihara, M.3    Koike, N.4    Ohsugi, Y.5    Nomura, S.6
  • 16
    • 57349088882 scopus 로고    scopus 로고
    • Monocyte chemokine protein-1 mRNA expression in experimental allergic encephalomyelitis rats treated with or without triptolide
    • C.G. Ma Y. Liu T.H. Ma H. Liu L.Y. Liang L.H. Zhang 2005 Monocyte chemokine protein-1 mRNA expression in experimental allergic encephalomyelitis rats treated with or without triptolide J Neurol Sci 238 234
    • (2005) J Neurol Sci , vol.238 , pp. 234
    • Ma, C.G.1    Liu, Y.2    Ma, T.H.3    Liu, H.4    Liang, L.Y.5    Zhang, L.H.6
  • 17
    • 5144222298 scopus 로고    scopus 로고
    • Specific antigen vaccination to treat autoimmune disease
    • H. McDevitt 2004 Specific antigen vaccination to treat autoimmune disease Proc Natl Acad Sci 101 14627 14630
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 14627-14630
    • McDevitt, H.1
  • 18
    • 0036498604 scopus 로고    scopus 로고
    • The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis
    • G.X. Zhang H. Xu M. Kishi D. Calida A. Rostami 2002 The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis J Immunol 168 2501 2507
    • (2002) J Immunol , vol.168 , pp. 2501-2507
    • Zhang, G.X.1    Xu, H.2    Kishi, M.3    Calida, D.4    Rostami, A.5
  • 19
    • 0035554898 scopus 로고    scopus 로고
    • Multiple sclerosis: A two-stage disease
    • L. Steinman 2001 Multiple sclerosis: a two-stage disease Nat Immunol 2 762 764
    • (2001) Nat Immunol , vol.2 , pp. 762-764
    • Steinman, L.1
  • 20
    • 0038297356 scopus 로고    scopus 로고
    • Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes
    • J. Cabarrocas J. Bauer E. Piaggio R. Liblau H. Lassmann 2003 Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes Eur J Immunol 33 1174 1182
    • (2003) Eur J Immunol , vol.33 , pp. 1174-1182
    • Cabarrocas, J.1    Bauer, J.2    Piaggio, E.3    Liblau, R.4    Lassmann, H.5
  • 21
    • 12344280009 scopus 로고    scopus 로고
    • Specificity, magnitude, and kinetics of MOG-specific CD8(+)T cell responses during experimental autoimmune encephalomyelitis
    • M.L. Ford B.D. Evavold 2005 Specificity, magnitude, and kinetics of MOG-specific CD8(+)T cell responses during experimental autoimmune encephalomyelitis Eur J Immunol 35 76 85
    • (2005) Eur J Immunol , vol.35 , pp. 76-85
    • Ford, M.L.1    Evavold, B.D.2
  • 22
    • 0031891009 scopus 로고    scopus 로고
    • Cytokine production and surface marker expression in acute and stable multiple sclerosis: Altered IL-12 production and augmented signaling lymphocytic activation molecule (SLAM)-expressing lymphocytes in acute multiple sclerosis
    • P. Ferrante M.L. Fusi M. Saresella D. Caputo M. Biasin D. Trabattoni 1998 Cytokine production and surface marker expression in acute and stable multiple sclerosis: altered IL-12 production and augmented signaling lymphocytic activation molecule (SLAM)-expressing lymphocytes in acute multiple sclerosis J Immunol 160 1514 1521
    • (1998) J Immunol , vol.160 , pp. 1514-1521
    • Ferrante, P.1    Fusi, M.L.2    Saresella, M.3    Caputo, D.4    Biasin, M.5    Trabattoni, D.6
  • 23
    • 0034633769 scopus 로고    scopus 로고
    • Apoptosis mediators FasL and TRAIL are upregulated in peripheral blood mononuclear cells in MS
    • W.X. Huang M.P. Huang M.A. Gomes J. Hillert 2000 Apoptosis mediators FasL and TRAIL are upregulated in peripheral blood mononuclear cells in MS Neurology 55 928 934
    • (2000) Neurology , vol.55 , pp. 928-934
    • Huang, W.X.1    Huang, M.P.2    Gomes, M.A.3    Hillert, J.4
  • 24
    • 0031253737 scopus 로고    scopus 로고
    • Fas-and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis
    • H. Waldner R.A. Sobel E. Howard V.K. Kuchroo 1997 Fas-and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis J Immunol 159 3100 3103
    • (1997) J Immunol , vol.159 , pp. 3100-3103
    • Waldner, H.1    Sobel, R.A.2    Howard, E.3    Kuchroo, V.K.4
  • 25
    • 33846295564 scopus 로고    scopus 로고
    • Mediators of apoptosis Fas and FasL predict disability progression in multiple sclerosis over a period of 10 years
    • L. Lopatinskaya J. Zwemmer B. Uitdehaag K. Lucas C. Polman L. Nagelkerken 2006 Mediators of apoptosis Fas and FasL predict disability progression in multiple sclerosis over a period of 10 years Mult Scler 12 704 709
    • (2006) Mult Scler , vol.12 , pp. 704-709
    • Lopatinskaya, L.1    Zwemmer, J.2    Uitdehaag, B.3    Lucas, K.4    Polman, C.5    Nagelkerken, L.6
  • 26
    • 27144460509 scopus 로고    scopus 로고
    • Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis
    • N. Hövelmeyer Z. Hao K. Kranidioti G. Kassiotis T. Buch F. Frommer 2005 Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis J Immunol 175 5875 5884
    • (2005) J Immunol , vol.175 , pp. 5875-5884
    • Hövelmeyer, N.1    Hao, Z.2    Kranidioti, K.3    Kassiotis, G.4    Buch, T.5    Frommer, F.6
  • 28
    • 35648938148 scopus 로고    scopus 로고
    • Diminished myelin-specific T cell activation associated with increase in CTLA4 and Fas molecules in multiple sclerosis patients treated with IFN-beta
    • D.E. Hallal-Longo S.R. Mirandola E.C. Oliveira A.S. Farias F.G. Pereira I.L. Metze 2007 Diminished myelin-specific T cell activation associated with increase in CTLA4 and Fas molecules in multiple sclerosis patients treated with IFN-beta J Interferon Cytokine Res 27 865 873
    • (2007) J Interferon Cytokine Res , vol.27 , pp. 865-873
    • Hallal-Longo, D.E.1    Mirandola, S.R.2    Oliveira, E.C.3    Farias, A.S.4    Pereira, F.G.5    Metze, I.L.6
  • 29
    • 0035378755 scopus 로고    scopus 로고
    • The molecular and cellular pathology of inflammatory muscle diseases
    • M.C. Dalakas 2001 The molecular and cellular pathology of inflammatory muscle diseases Curr Opin Pharmacol 1 300 306
    • (2001) Curr Opin Pharmacol , vol.1 , pp. 300-306
    • Dalakas, M.C.1
  • 31
    • 49649111913 scopus 로고    scopus 로고
    • B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis
    • S. Ortler C. Leder M. Mittelbronn A.L. Zozulya P.A. Knolle L. Chen 2008 B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis Eur J Immunol 38 1734 1744
    • (2008) Eur J Immunol , vol.38 , pp. 1734-1744
    • Ortler, S.1    Leder, C.2    Mittelbronn, M.3    Zozulya, A.L.4    Knolle, P.A.5    Chen, L.6
  • 32
    • 33645243957 scopus 로고    scopus 로고
    • Structural insight into the role of myelin basic protein in multiple sclerosis
    • C. Husted 2006 Structural insight into the role of myelin basic protein in multiple sclerosis Proc Natl Acad Sci 103 4339 4340
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 4339-4340
    • Husted, C.1
  • 33
    • 0344244785 scopus 로고
    • Components in multiple sclerosis cerebrospinal fluid that are detected by radioimmunoassay for myelin basic protein
    • J.H. Carson E. Barbarese P.E. Braun T.A. McPherson 1978 Components in multiple sclerosis cerebrospinal fluid that are detected by radioimmunoassay for myelin basic protein Proc Natl Acad Sci 75 1976 1978
    • (1978) Proc Natl Acad Sci , vol.75 , pp. 1976-1978
    • Carson, J.H.1    Barbarese, E.2    Braun, P.E.3    McPherson, T.A.4
  • 34
    • 0021966856 scopus 로고
    • T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination
    • S. Zamvil P. Nelson J. Trotter D. Mitchell R. Knobler R. Fritz 1985 T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination Nature 317 355 358
    • (1985) Nature , vol.317 , pp. 355-358
    • Zamvil, S.1    Nelson, P.2    Trotter, J.3    Mitchell, D.4    Knobler, R.5    Fritz, R.6
  • 35
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8 T cells in a model for multiple sclerosis
    • E.S. Huseby D. Liggitt T. Brabb B. Schnabel C. Ohlén J. Goverman 2001 A pathogenic role for myelin-specific CD8 T cells in a model for multiple sclerosis J Exp Med 194 669 676
    • (2001) J Exp Med , vol.194 , pp. 669-676
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlén, C.5    Goverman, J.6
  • 36
    • 0031110114 scopus 로고    scopus 로고
    • Chemokine and matrix metalloproteinase secretion by myelin proteolipid protein specific CD8+ T cells: Potential roles in inflammation
    • W.E. Biddison D.D. Taub W.W. Cruikshank D.M. Center E.W. Connor K. Honma 1997 Chemokine and matrix metalloproteinase secretion by myelin proteolipid protein specific CD8+ T cells: potential roles in inflammation J Immunol 158 3046 3053
    • (1997) J Immunol , vol.158 , pp. 3046-3053
    • Biddison, W.E.1    Taub, D.D.2    Cruikshank, W.W.3    Center, D.M.4    Connor, E.W.5    Honma, K.6
  • 37
    • 25444464602 scopus 로고    scopus 로고
    • Myelin basic proteinprimed T cells of female but not male mice induce nitric-oxide synthase and proinflammatory cytokines in microglia: Implications for gender bias in multiple sclerosis
    • S. Dasgupta M. Jana X.J. Liu K. Pahan 2005 Myelin basic proteinprimed T cells of female but not male mice induce nitric-oxide synthase and proinflammatory cytokines in microglia: implications for gender bias in multiple sclerosis J Biol Chem 280 32609 32617
    • (2005) J Biol Chem , vol.280 , pp. 32609-32617
    • Dasgupta, S.1    Jana, M.2    Liu, X.J.3    Pahan, K.4
  • 38
    • 10044249878 scopus 로고    scopus 로고
    • Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation
    • F. Aboul-Enein J. Bauer M. Klein A. Schubart A. Flügel T. Ritter 2004 Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation J Neuropathol Exp Neurol 63 1284 1296
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 1284-1296
    • Aboul-Enein, F.1    Bauer, J.2    Klein, M.3    Schubart, A.4    Flügel, A.5    Ritter, T.6
  • 39
    • 23744454283 scopus 로고    scopus 로고
    • Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange
    • M. Keegan F. König R. McClelland W. Brück Y. Morales A. Bitsch 2005 Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange Lancet 366 579 582
    • (2005) Lancet , vol.366 , pp. 579-582
    • Keegan, M.1    König, F.2    McClelland, R.3    Brück, W.4    Morales, Y.5    Bitsch, A.6
  • 40
    • 0027733797 scopus 로고
    • The demyelinating potential of antibodies to myelin oligoden-drocyte glycoprotein is related to their ability to fix complement
    • S.J. Piddlesden H. Lassmann F. Zimprich B.P. Morgan C. Linington 1993 The demyelinating potential of antibodies to myelin oligoden-drocyte glycoprotein is related to their ability to fix complement Am J Pathol 143 555 564
    • (1993) Am J Pathol , vol.143 , pp. 555-564
    • Piddlesden, S.J.1    Lassmann, H.2    Zimprich, F.3    Morgan, B.P.4    Linington, C.5
  • 41
    • 33144474262 scopus 로고    scopus 로고
    • Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis
    • P.H. Lalive T. Menge C. Delarasse B. Della Gaspera D. Pham-Dinh P. Villoslada 2006 Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis Proc Natl Acad Sci 103 2280 2285
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 2280-2285
    • Lalive, P.H.1    Menge, T.2    Delarasse, C.3    Della Gaspera, B.4    Pham-Dinh, D.5    Villoslada, P.6
  • 42
    • 0035283493 scopus 로고    scopus 로고
    • The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls
    • C.G. Haase J. Guggenmos U. Brehm M. Andersson T. Olsson M. Reindl 2001 The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls J Neuroimmunol 114 220 225
    • (2001) J Neuroimmunol , vol.114 , pp. 220-225
    • Haase, C.G.1    Guggenmos, J.2    Brehm, U.3    Andersson, M.4    Olsson, T.5    Reindl, M.6
  • 43
    • 33846449107 scopus 로고    scopus 로고
    • Lack of association between antimyelin antibodies and progression to multiple sclerosis
    • J. Kuhle C. Pohl M. Mehling G. Edan M.S. Freedman H.P. Hartung 2007 Lack of association between antimyelin antibodies and progression to multiple sclerosis N Engl J Med 356 371 378
    • (2007) N Engl J Med , vol.356 , pp. 371-378
    • Kuhle, J.1    Pohl, C.2    Mehling, M.3    Edan, G.4    Freedman, M.S.5    Hartung, H.P.6
  • 44
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    • E. Zappia S. Casazza E. Pedemonte F. Benvenuto I. Bonanni E. Gerdoni 2005 Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy Blood 106 1755 1761
    • (2005) Blood , vol.106 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3    Benvenuto, F.4    Bonanni, I.5    Gerdoni, E.6
  • 45
    • 20144368500 scopus 로고    scopus 로고
    • Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: Impact on disease activity and quality of life
    • R. Saccardi G.L. Mancardi A. Solari A. Bosi P. Bruzzi P. DiBartolomeo 2005 Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life Blood 105 2601 2607
    • (2005) Blood , vol.105 , pp. 2601-2607
    • Saccardi, R.1    Mancardi, G.L.2    Solari, A.3    Bosi, A.4    Bruzzi, P.5    Dibartolomeo, P.6


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