Cytokine production and surface marker expression in acute and stable multiple sclerosis: Altered IL-12 production and augmented signaling lymphocytic activation molecule (SLAM)-expressing lymphocytes in acute multiple sclerosis

Journal of Immunology

Volumn 160, Issue 3, 1998, Pages 1514-1521

  Ferrante, Pasquale ^a   Fusi, Maria Luisa ^a   Saresella, Marina ^b   Caputo, Domenico ^b   Biasin, Mara ^a   Trabattoni, Daria ^a   Salvaggio, Antonino ^c   Clerici, Enrico ^a   De Vries, Jan E ^e   Aversa, Gregorio ^e   Cazzullo, Carlo L ^d   Clerici, Mario ^a,c  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d Assoc Ricerca Schizofrenia ARS   (Italy)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD7 ANTIGEN; CD86 ANTIGEN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; MITOGENIC AGENT;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATION; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; INFLAMMATION; LYMPHOCYTE ACTIVATION; MALE; MULTIPLE SCLEROSIS; PHENOTYPE; PRIORITY JOURNAL;

ACUTE DISEASE; ADULT; ANTIGENS, CD; ANTIGENS, CD7; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, CD95; ANTIGENS, SURFACE; BIOLOGICAL MARKERS; CYTOKINES; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULINS; IMMUNOPHENOTYPING; INFLUENZA A VIRUS; INTERLEUKIN-12; ISOANTIGENS; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MONOCYTES; MULTIPLE SCLEROSIS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SOLUBILITY; TH1 CELLS;

EID: 0031891009     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Lublin, F. D., and S. C. Reingold. 1996. Denning the clinical course of multiple sclerosis: results of an international survey. Neurology 46:907.
2. Thompson A. J., A. G. Kermode, and D. Wicks. 1991. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann. Neurol. 29:53.
3. Poser, C. M. 1993. The pathogenesis of multiple sclerosis: additional consideration. J. Neurol. Sci. 115(Suppl.):S3.
4. Martin, R., and H. F. McFarland. 1995. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit. Rev. Clin. Lab. Sci. 32: 121.
5. Giovannoni, G., and P. Hartung. 1996. The immunopathogenesis of multiple sclerosis and Guillain-Barré syndrome. Curr. Opin. Neurol. 9:165.
6. Steinman, L. 1996. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85:299.
7. Wucherpfenning, K., J. Zhang, C. Witek, M. Matsui, Y. Modabber, K. Ota, and D. Hafler. 1994. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152:5581.
8. Wucherpfenning, K., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
9. Olsson, T., W. Z. Wang, B. Hojeberg, and J. Link. 1990. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon gamma. J. Clin. Invest. 86:981.
10. Link, J., M. Soderstrom, T. Olsson, and B. Hojeberg. 1994. Increased TGFβ, IL-4, and IFNα in multiple sclerosis. Ann. Neurol 36:379.
11. Rieckmann, P., M. Albrecht, B. Kitze, T. Weber, H. Tumani, A. Broocks, W. Luer, A. Helwig, and S. Poser. 1995. Tumor necrosis factor-α messenger RNA expression in patients with multiple sclerosis is associated with disease activity. Ann. Neurol. 32:82.
12. Navikas, V., B. He, J. Link, M. Haglund, M. Sodderstrom, S. Fredrickson, and H. Link. 1996. Augmented expression of tumor necrosis a and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. Brain 119:213.
13. Rieckmann, P., M. Albrecht, and B. Kitze. 1994. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology 44: 1523.
14. Arnason, B. 1995. The role of cytokines in multiple sclerosis. Neurology 45 (Suppl. 6):S54.
15. Hohlfeld, R., and K. Lucas. 1994. Cytokine networks in multiple sclerosis. Neurology 45(Suppl. 6):S1.
16. Olsson, T., J. Sun, J. Killer, B. Hojeberg, H.-P. Ekre, G. Andersson, O. Olerup, and H. Link. 1992. Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis. Eur. J. Immunol. 22:1083.
17. Sun, J. B., T. Olsson, W. Z. Wang, and J. Hiller. 1991. Autoreactive T and B cell cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 21:1461.
18. Sun, J. B., J. Link, and B. G. Xiao. 1991. Autoreactive T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 46:1490.
19. Panitch, H. S., R. I. Heracl, J. Schindler, and K. P. Johnson. 1987. Treatment of MS with gamma interferon: exacerbations associated with activation of the immune system. Neurology 37:1097.
20. Billiau, A. 1995. Interferons in multiple sclerosis: warnings from experiences. Neurology 45(Suppl. 6):S50.
21. The IFNβ Multiple Sclerosis Group. 1993. Interferon beta-1α is effective in relapsing-remitting multiple sclerosis. Neurology 43:655.
22. Paty, D. W., D. K. B. Li, the UBC MS/MRI Study Group, and the IFNβ Multiple Sclerosis Group. 1993. Interferon α-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double blind, placebo controlled trial. Neurology 43:662.
23. Mossmann, T. R., and R. I. Coffman. 1987. Two types of mouse T helper cell clone: implication for immune regulation. Immunol. Today 8:223.
24. Mossmann, T. R., and R. I. Coffman. 1989. TH1 and TH2 cells: different pattern of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
25. Cocks, B. G., C. C. J. Chang, J. M. Carballido, H. Yssel, J. E. de Vries, and G. Aversa. 1995. A novel receptor involved in T-cell activation. Nature 376:260.
26. - T helper cells from normal donors and HTV-infected patients. J. Immunol. 154:1408.
27. Reiser, H., and M. J. Stadecker. 1996. Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases. N. Engl. J. Med. 335:1369.
28. Guinan, E. C., I. G. Gribben, V. A. Boussiotis, G. J. Freeman, and L. M. Nadler. 1994. Pivotal role of the B7: CD28 pathway in transplantation tolerance and tumor immunity. Blood 84:3261.
29. Ameisen, J.-C. 1994. Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer. AIDS 8:1197.
30. Alderson, M. R., T. W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K. A. Schooley, R. G. Goodwin, C. A. Smith, F. Ramsdell, and D. H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T cell lymphocytes. J. Exp. Med. 181:71.
31. Cheng, J., T. Zhou, C. Liu, J. P. Shapiro, M. J. Brauer, M. C. Kiefer, P. J. Barr, and J. D. Munoz. 1994. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263:1759.
32. Clerici, M., F. T. Hakim, D. J. Venzon, S. Blatt, C. W. Hendrix, T. A. Wynn, and G. M. Shearer. 1993. Changes in interleukin 2 and interleukin 4 production in asymptomatic, HIV-seropositive individuals. J. Clin. Invest. 91:759.
33. Clerici, M., T. A. Wynn, J. A. Berzofsky, R. L. Coffman, A. Sher, and G. M. Shearer. 1994. Role of interleukin-10 (IL-10) in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus (HIV-1). J. Clin. Invest. 93:768.
34. + cell numbers and clinical staging. J. Clin. Invest. 84: 1892.
35. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familietti, and M. K. Gateley. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88:4143.
36. Correale, I., W. Gilmore, M. McMillan, S. Li, K. McCarthy, T. Le, and L. P. Wiener. 1995. Patterns of cytokine secretion by autoreactive proteolipid-protein-specific T cell clones during the course of multiple sclerosis. J. Immunol. 15:2959.
37. Heinzel, F. P., A. M. Hujer, F. N. Ahmed, and R. M. Rerko. 1997. In vivo production of IL-12 p40 homodimers. J. Immunol. 158:4381.
38. Kato, K., O. Shimozato, K. Hoshi, H. Wakimoto, H. Hamada, H. Yagita, and K. Okumura. 1996. Local production of the p40 subunit of IL12 suppresses T helper 1-mediated immune responses and prevents allogeneic myoblast rejection. J. Immunol. 156:9085.
39. Windhagen, A., J. Newcombe, F. Dangond, C. Strand, M. N. Woodrofe, M. L. Cuzner, and D. A. Hafler. 1995. Expression of costimulatory molecules B7-1 (CD80). B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J. Exp. Med. 182:1985.
40. Mantovani, A., F. Bussolino, and M. Introna. 1997. Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol. Today 18:231.
41. Porrini, A. M., D. Gambi, and G. Malestra. 1992. Memory and naive CD4 lymphocytes in multiple sclerosis. Neurology 239:437.
42. Bongioanni, P., C. Fioretti, R. Vanacore, F. Bianchi, F. Lombardo, F. Ambrogi, and G. Meucci. 1996. Lymphocyte subsets in multiple sclerosis. A study with two-colour fluorescence analysis. J. Neurol. Sci. 139:71.
43. Kruzfelder, E., G. Shen, M. Bittorof, N. Scheiermann, O. Thraenhart, D. Seidell, and H. Grosse-Wilde. 1992. Enumeration of T. B and natural killer peripheral blood cells of patients with multiple sclerosis and controls. Eur. Neurol. 32:190.
44. Ilonen, J., H. M. Surcel, H. Jagerroos, T. Nurmi, and M. Reunanen. 1990. T lymphocyte subsets defined by double immunofluorescence in multiple sclerosis. Acta Neurol. Scand. 81:128.
45. Aversa, G., C.-C. J. Chang, J. M. Carbadillo, B. G. Cocks, and J. E. de Vries. 1997. Engagement of the signalling activation molecule (SLAM) on activated T cells results in IL-2 independent cyclosporin A-sensitive T cell proliferation and IFN-γ production. J. Immunol. 158:4036.
46. Shahinian, A., K. Pfeffer, and K. P. Lee. 1993. Differential T cell costimulatory requirements in CD28 deficient mice. Science 261:609.
47. Kuchroo, V. K., M. P. Das, and J. A. Brown. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the TH1/TH2 development pathways: application to autoimmune disease therapy. Cell 80:707.
48. Bluestone, J. A. 1995. New perspectives on CD28-B7-mediated T cell costimulation. Immunity 2:555.
49. Miller, S. D., C. L. Vanderlugt, and D. J. Lenschow. 1995. Blockage of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3:739.
50. Cazzullo, C. L., and A. Ferraro. 1949. Isoallergic encephalomyelitis produced in guinea pigs via intramuscular and intraperitoneal injection of antigen. Arch. Pathol. 48:316.
51. Ito, N., S. Yoncara, A. Ishii, M. Yoncara, S. Mitsushima, M. Sameshima, A. Hase, Y. Sato, and N. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediated apoptosis. Cell 75:1169.
52. Ju, S.-T., D. J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D. H. Sherr, B. Z. Stunger, and A. Marshak-Rothstein. 1995. Fas (CD95)/FasL interactions required for programmed cell death after T cell activation. Nature 373:444.
53. Dhein, J., H. Walczac, C. Baumler, K.-M. Debatin, and P. H. Krammer. 1995. Autocrine T cell suicide mediated by APO-1 (Fas/CD95). Nature 373:438.
54. Tanaka, M., T. Suda, K. Haze, N. Nakamura, S. Sato, F. Kimura, K. Motoyoshi, M. Mizuki, S. Tagawa, S. Ohga, K. Hatake, A. H. Drummond, and S. Nagata. 1996. Fas ligand in human serum. Nat. Med. 2:317.
55. Katsikis, P. D., E. S. Wunderlich, C. A. Smith, L. A. Herzenberg, and L. A. Herzenberg. 1995. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus infected individuals. J. Exp. Med. 181:2029
56. + lymphocyte depletion and human immunodeficiency virus replication. Blood 89:1357.
57. Strand, S., W. J. Hofman, H. Hug, M. Muller, G. Otto, D. Strand, S. M. Mariani, W. Stremmel, P. H. Krammer, and P. R. Galle. 1996. Lymphocyte apoptosis induced by CD95 ligand-expressing tumor cells: a mechanism for immune evasion? Nat. Med. 1:1361.
58. McCloskey, T. W., N. Oyazu, M. Kaplan, and S. Pahwa. 1995. Expression of the Fas antigen on patients infected with HIV. Cytometry 22:111.
59. Debatin, K.-M., A. Fahrig-Faissner, S. Enenkel-Stoodt, W. Kreuz, A. Benner, and P. H. Krammer. 1994. High expression of Apo-1 (CD95) on T lymphocytes from HIV-infected children. Blood 83:3101.
60. Silvestris, F., P. Cafforio, M. A. Frassanito, M. Tucci, A. Romito, S. Nagata, and F. Dammacco. 1996. Overexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis. AIDS 10:131.
61. + T lymphocytes from HIV-infected individuals is mediated by FasL and TNF. J. Exp. Med. 185: 55.
62. + T cells via Fas/Fas ligand-mediated apoptosis. J. Immunol. 158:528.