Myelin basic protein-primed T cells of female but not male mice induce nitric-oxide synthase and proinflammatory cytokines in microglia: Implications for gender bias in multiple sclerosis

Journal of Biological Chemistry

Volumn 280, Issue 38, 2005, Pages 32609-32617

  Dasgupta, Subhajit ^a   Jana, Malabendu ^a   Liu, Xiaojuan ^a   Pahan, Kalipada ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOCHEMISTRY; MOLECULAR BIOLOGY; NITROGEN OXIDES; PROTEINS;

CYTOKINES; MICE; MULTIPLE SCLEROSIS (MS); PROINFLAMMATORY MOLECULES;

CELLS;

CCAAT ENHANCER BINDING PROTEIN BETA; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELIN BASIC PROTEIN; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL CONTACT; CELL ISOLATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENDER; MALE; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; T LYMPHOCYTE;

ANIMALS; CASTRATION; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL MEMBRANE; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; CYTOKINES; FEMALE; GENES, DOMINANT; IMMUNOBLOTTING; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-6; MALE; MICE; MICROGLIA; MULTIPLE SCLEROSIS; MUTATION; MYELIN BASIC PROTEINS; NF-KAPPA B; NITRIC OXIDE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA; SEX FACTORS; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 25444464602     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500299200     Document Type: Article

References (45)

1. Duquette, P., Pleines, J., Girard, M., Charest, L., Senecal-Quevillon, M., and Masse, C. (1992) Can. J. Neurol. Sci. 19, 466-471
2. Jacobson, D. L., Gange, S. J., Rose, N. R., and Graham, N. M. (1997) Clin. Immunol. Immunopathol. 84, 223-243
3. Voskuhl, R. R., and Palaszynski, K. (2001) Neuroscientist 7, 258-270
4. Voskuhl, R. R., Pitchekian-Halabi, H., MacKenzie-Graham, A., McFarland, H. F., and Raine, C. S. (1996) Ann. Neurol. 39, 724-733
5. Roubinian, J. R., Talal, N., Greenspan, I. S., Goodman, J. R., and Siiteri, P. K. (1978) J. Exp. Med. 147, 1568-1583
6. Makino, S., Kunimoto, K., Muraoka, Y., and Katagiri, K. (1981) Jikken Dobutsu. 30, 137-140
7. Sato, E. H., Ariga, H., and Sullivan, D. A. (1992) Investig. Ophthalmol. Vis. Sci. 33, 2537-2545
8. Martin, R., McFarland, H. F., and McFarlin, D. E. (1992) Annu. Rev. Immunol. 10, 153-187
9. Benveniste, E. N. (1997) J. Mol. Med. 75, 165-173
10. Bo, L., Dawson, T. M., Wesselingh, S., Mork, S., Choi, S., Kong, P.A., Hanley, D., and Trapp, B. D. (1994) Ann. Neurol. 36, 778-786
11. Bagsra, O., Michaels, F. H., Zheng, Y. M., Bobroski, L. E., Spitsin, S. V., Fu, Z. F., Tawadros, R., and Koprowski, H. (1996) Proc. Natl. Acad. Sci. U. S. A. 92, 12041-12045
12. Brenner, T. Brocke, S., Szafer, F., Sobel, R. A., Parkinson, J. F., Perez, D. H., and Steinman, L. (1997) J. Immunol. 158, 2940-2946
13. Hooper, D. C., Bagasra, O., Marini, J. C., Zborek, A., Ohnishi, S. T., Kean, R., Champion, J. M., Sarker, A. B., Bobroski, L., Farber, I. L., Akaike, T., Maeda, H., and Koprowski, H. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2528-2533
14. Hooper, D. C., Spitsin, S., Kean, R. B., Champion, J. M., Dickson, G. M., Chaudhry, I., and Koprowski, H. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 675-680
15. Tyor, W. R., Glass, J. D., Baumrind, N., McArthur, J. C., Griffin, J. W., Becker, P. S., and Griffin, D. E. (1993) Neurology 43, 1002-1009
16. Brosnan, C. F., and Raine, C. S. (1996) Brain Pathol. 6, 243-257
17. Sharief, M. K., and Hentges, R. (1991) N. Engl. J. Med. 325, 467-472
18. Maimone, D., Gregory, S., Arnason, B. G., and Reder, A. T. (1991) J. Neuroimmunol. 32, 67-74
19. Ruddle, N. H., Bergman, C. M., McGrath, K. M., Lingenheld, E. G., Grunnet, M. L., Padula, S. J., and Clark, R. B. (1990) J. Exp. Med. 172, 1193-1200
20. Samoilova, E. B., Horton, J. L., Milliard, B., Liu, T. S., and Chen, Y. (1998) J. Immunol. 161, 6480-6486
21. Esiri, M. M., and Gay, D. (1997) in Multiple Sclerosis: Clinical and Pathogenetic Basis (Raine, C. S., McFarland, H. F., and Tourtellotte, W. W., eds) pp. 173-186, Chapman & Hall, London
22. Dasgupta, S., Jana, M., Liu, X., and Pahan, K. (2002) J. Biol. Chem. 277, 39327-39333
23. Dasgupta, S., Jana, M., Liu, X., and Pahan, K. (2003) J. Biol. Chem. 278, 22424-22431
24. Jana, M., Dasgupta, S., Saha, R. N., Liu, X., and Pahan, K. (2003) J. Neurochem. 86, 519-528
25. Giulian, D., and Baker, T. J. (1986) J. Neurosci. 6, 2163-2178
26. Jana, M., Liu, X., Koka, S., Ghosh, S., Petro, T. M., and Pahan, K. (2001) J. Biol. Chem. 276, 44527-44533
27. Pahan, K., Sheikh, F. G., Liu, X., Hilger, S., McKinney, M., and Petro, T. M. (2001) J. Biol. Chem. 276, 7899-7905
28. Jana, M., Dasgupta, S., Liu, X., and Pahan, K. (2002) J. Neurochem. 80, 197-203
29. Bradford, M. (1976) Anal. Biochem. 72, 248-254
30. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. (1983) Nucleic Acids Res. 11, 1475-1489
31. Liu, X., Jana, M., Dasgupta, S., Koka, S., He, J., Wood, C., and Pahan, K. (2002) J. Biol. Chem. 277, 39312-39319
32. Ding, M., Wong, J. L., Rogers, N. E., Ignarro, L. J., and Voskuhl, R. R. (1997) J. Neuroimmunol. 77, 99-106
33. Yao, J., Mackman, N., Edgington, T. S., and Fan, S. T. (1997) J. Biol. Chem. 272, 17795-17801
34. Hu, H. M., Tian, Q., Baer, M., Spooner, C. J., Williams, S. C., Johnson, P. F., and Schwartz, R. C. (2000) J. Biol. Chem. 275, 16373-16381
35. Ghosh, S., May, M. J., and Kopp, E. B. (1998) Annu. Rev. Immunol. 16, 225-260
36. Liu, H., MacKenzie-Graham, A. J., Palaszynski, K., Liva, S., and Voskuhl, R. R. (2001) J. Neuroimmunol. 116, 83-93
37. Iglesias, A., Bauer, J., Litzenburger, T., Schubart, A., and Linington, C. (2001) Glia 36, 220-234
38. Utz, U., and McFarland, H. F. (1994) J. Neuropathol. Exp. Neurol. 53, 351-358
39. Chabot, S., and Yong, V. W. (2000) Neurology 55, 1497-1505
40. Sedgwick, J. D., Ford, A. L., Foulcher, E., and Airriess, R. (1998) J. Immunol. 160, 5320-5330
41. Traugott, U., Reinherz, E. L., and Raine, C. S. (1983) Science 218, 308-310
42. Gonzalez-Scarano, F., and Baltuch, G. (1999) Annu. Rev. Neurosci. 22, 219-240
43. Cross, A. H., O'Mara, T., and Raine, C. S. (1993) Neurology 43, 1028-1033
44. Udalova, I. A., Knight, J. C., Vidal, V., Nedospasov, S. A., and Kwiatkowski, D. (1998) J. Biol. Chem. 273, 21178-21186
45. Heiss, E., Herhaus, C., Klimo, K., Bartsch, H., and Gerhauser, C. (2001) J. Biol. Chem. 276, 32008-32015