The repopulation potential of hepatocyte populations differing in size and prior mitotic expansion

American Journal of Pathology

Volumn 155, Issue 6, 1999, Pages 2135-2143

  Overturf, Ken ^a   Al Dhalimy, Muhsen ^a   Finegold, Milton ^b   Grompe, Markus ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL DIVISION; CELL POPULATION; CELL REGENERATION; CELL SIZE; CONTROLLED STUDY; LIVER CELL; LIVER DISEASE; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION;

EID: 0032805945     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65531-9     Document Type: Article

References (35)

1. Michalopoulos GK, DeFrances MC: Liver regeneration. Science 1997, 276:60-66
2. Alison MR, Golding M, Sarraf CE: Liver stem cells: when the going gets tough they get going. Int J Exp Pathol 1997, 78:365-381
3. Alison M, Golding M, Lalani EN, Nagy P, Thorgeirsson S, Sarraf C: Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells. J Hepatol 1997, 26:343-352
4. Grompe M, Al-Dhalimy M, Finegold M, Ou CN, Burlingame T, Kennaway NG, Soriano P: Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev 1993, 7:2298-2307
5. Mitchell GA, Grompe M, Lambert M, Tanguay RM: Hypertyrosinemia. The Metabolic Basis of Inherited Disease, vol. 1. Edited by CR Scriver, AL Beaudet, W Sly, D Valle. New York, McGraw-Hill, 1999, pp 1077-1106
6. Overturf K, Al-Dhalimy M, Tanguay R, Brantly M, Ou CN, Finegold M, Grompe M: Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet 1996, 12:266-273
7. Kvittingen EA, Rootwelt H, Berger R, Brandtzaeg P: Self-induced correction of the genetic defect in tyrosinemia type I. J Clin Invest 1994, 94:1657-1661
8. Grompe M, Lindstedt S, al-Dhalimy M, Kennaway NG, Papaconstantinou J, Torres-Ramos CA, Ou CN, Finegold M: Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nat Genet 1995, 10:453-460
9. Overturf K, Al-Dhalimy M, Ou CN, Finegold M, Grompe M: Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 1997, 151:1273-1280
10. Yasui O, Miura N, Terada K, Kawarada Y, Koyama K, Sugiyama T: Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver. Hepatology 1997, 25:329-334
11. Alpini G, Phillips JO, Vroman B, LaRusso NF: Recent advances in the isolation of liver cells. Hepatology 1994, 20:494-514
12. Harrison DE, Astle CM: Loss of stem cell repopulating ability upon transplantation: effects of donor age, cell number, and transplantation procedure. J Exp Med 1982, 156:1767-1779
13. Cepko CL, Ryder EF, Austin CP, Walsh C, Fekete DM: Lineage analysis using retrovirus vectors. Methods Enzymol 1993, 225:933-960
14. Friedrich G, Soriano P: Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 1991, 5:1513-1523
15. Whitney MA, Royle G, Low MJ, Kelly MA, Axthelm MK, Reifsteck C, Olson S, Braun RE, Heinrich MC, Rathbun RK, Bagby GC, Grompe M: Germ cell defects and hematopoietic hypersensitivity to γ-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood 1996, 88:49-58
16. Kelly MA, Rubinstein M, Asa SL, Zhang G, Saez C, Bunzow JR, Allen RG, Hnasko R, Ben-Jonathan N, Grandy DK, Low MJ: Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 1997, 19:103-113
17. Schulz A, Ort O, Beyer P, Kleinig H: SC-0051, a 2-benzoyl-cyclohexane-1,3-dione bleaching herbicide, is a potent inhibitor of the enzyme p-hydroxyphenylpyruvate dioxygenase. FEBS Lett 1993, 318:162-166
18. Grompe M, Jones SN, Loulseged H, Caskey CT: Retroviral-mediated gene transfer of human ornithine transcarbamylase into primary hepatocytes of spf and spf-ash mice. Hum Gene Ther 1992, 3:35-44
19. Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, DeMayo J, Ledley FD, Chowdhury JR, Woo SL: Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci USA 1991, 88:1217-1221
20. Overturf K, Al-Dhalimy M, Manning K, Ou CN, Finegold M, Grompe M: Ex vivo hepatic gene therapy of a mouse model of hereditary tyrosinemia type I. Hum Gene Ther 1998, 9:295-304
21. Darlington GJ, Kelley JH, Buffone GJ: Growth and hepatospecific gene expression of human hepatoma cells in a defined medium. In Vitro Cell Dev Biol 1987, 23:349-354
22. Sambrook J, Fritsch EF, Maniatis T (editors): Molecular Cloning: A Laboratory Manual., Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1989
23. Labelle Y, Puymirat J, Tanguay RM: Localization of cells in the rat brain expressing fumarylacetoacetate hydrolase, the deficient enzyme in hereditary tyrosinemia type 1. Biochim Biophys Acta 1993, 1180:250-256
24. Michel M, Torok N, Godbout MJ, Lussier M, Gaudreau P, Royal A, Germain L: Keratin 19 as a biochemical marker of skin stem cells in vivo, and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage. J Cell Sci 1996, 109:1017-1028
25. Laplante AF, Moulin V, Auger FA, Landry J, Li H, Morrow G, Tanguay RM, German L: Expression of heat shock proteins in mouse skin during wound healing. J Histochem Cytochem 1998, 46:1291-1301
26. Bucher NLR, Swaffield MN: The rate of incorporation of labeled thymidine into the deoxyribonucleic acid of regenerating rat liver in relation to the amount of liver excised. Cancer Res 1964, 240:1611-1625
27. Goff SP: Genetics of retroviral integration. Annu Rev Genet 1992, 26:527-544
28. Grompe M, Laconi E, Shafritz DA: Principles of therapeutic liver repopulation. Semin Liver Dis 1999, 19:7-14
29. Sandgren EP, Palmiter RD, Heckel JL, Daugherty CC, Brinster RL, Degen JL: Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell 1991, 66:245-256
30. Laconi E, Oren R, Mukhopachyay DK, Hurston E, Laconi S, Pani P, Dabeva MD, Shafritz DA: Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998, 153:319-329
31. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, Dorko K, Sauter BV, Strom SC: Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998, 338:1422-1426
32. Grossman M, Raper SE, Kozarsky K, Stein EA, Engelhardt JF, Muller D, Lupien PJ, Wilson JM: Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolemia. Nat Genet 1994, 6:335-341
33. Prowse KR, Greider CW: Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci USA 1995, 92:4818-4822
34. Bucher N, Swaffield M, DiTroia J: The influence of age upon the incorporation of thymidine-2-C14 into the DNA of regenerating rat liver. Cancer Res 1964, 24:509-512
35. Beyer HS, Sherman R, Zieve L: Aging is associated with reduced liver regeneration and diminished thymidine kinase mRNA content and enzyme activity in the rat. J Lab Clin Med 1991, 117:101-108