The antithrombotic effects of carrot filtrates in rats and mice

Blood Coagulation and Fibrinolysis

Volumn 19, Issue 8, 2008, Pages 785-792

  Yamamoto, Junichiro ^a   Naemura, Aki ^a   Ijiri, Yoshinobu ^a,b   Ogawa, Koji ^c   Suzuki, Takao ^d   Shimada, Yasuhiko ^d   Giddings, John C ^e  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b HYOGO UNIVERSITY   (Japan)

^c ONO PHARMACEUTICAL CO   (Japan)

^d Sakata Seed Ibérica SLU   (Japan)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Cardiovascular disease; Carrot; Food; Stroke; Thrombolysis; Thrombosis

Indexed keywords

ALPHA CAROTENE; ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; POLYPHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLOOD CLOT LYSIS; CARROT; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE ACTIVATION; THROMBOSIS; VARIETAS;

ANIMALS; DAUCUS CAROTA; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FIBRINOLYTIC AGENTS; FILTRATION; MICE; PHYTOTHERAPY; PLATELET AGGREGATION INHIBITORS; RATS; THROMBOLYTIC THERAPY; THROMBOSIS;

EID: 57149108952     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e3283177b19     Document Type: Article

References (28)

1. Lichtenstein AH, Appel LJ, Brands M, Camethon M, Daniels S, Franch HA, et al. Summary of American Heart Association Diet and Lifestyle Recommendations Revision 2006. Arterioscler Thromb Vasc Biol 2006; 26:2186-2191.
2. Ulbricht TL, Southgate DA. Coronary heart disease: seven dietary factors. Lancet 1991; 338:985-992.
3. Renaud S, De Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339:1523-1526.
4. Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, et al. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 1999; 282:1233-1239.
5. Liu S, Manson JE, Lee IM, Cole SR, Hennekens CH, Willett WC, Buring JE. Fruit and vegetable intake and risk of cardiovascular disease: the women's health study. Am J Clin Nutr 2000; 72:922-928.
6. Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, et al. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 2001; 134:1106-1114.
7. Bazzano LA, He J, Ogden LG, Loria CM, Vupputuri S, Myers L, Whelton PK. Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first national health and nutrition examination survey epidemiologic follow-up study. Am J Clin Nutr 2002; 76:93-99.
8. Ratnatunga CP, Edomondson SF, Rees GM, Kovacs IB. High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation. Circulation 1982; 85:1077-1082.
9. Gorog DA, Kovacs IB. Thrombotic status analyser. Thromb Haemost 1995; 73:514-520.
10. Yamamoto J. Prediction of thrombotic status by a new test and prevention of thrombotic disorders by foods with antithrombotic activity [Review]. The 7th TTM Forum Report; 2007. pp. 203-220 [Japanese].
11. Yamamoto J, Taka T, Yamada K, Ijiri Y, Murakami M, Hirata Y, et al. Tomatoes have natural antithrombotic effects. Br J Nutr 2003; 90:1031-1038.
12. Yamada K, Naemura A, Sawashita N, Noguchi Y, Yamamoto J. An onion variety has natural antithrombotic effect as assessed by thrombosis/thrombolysis. Thromb Res 2004; 114:213-220.
13. Naemura A, Mitani T, Ijiri Y, Tamura V, Yamashita T, Okimura M, Yamamoto J. Antithrombotic effect of strawberries. Blood Coagul Fibrinolysis 2005; 16:501-509.
14. Yamamoto J, Naemura A, Ura M, Ijiri Y, Yamashita T, Kurioka A, Koyama A. Testing various fruits for antithrombotic effect: I. Mulberries. Platelets 2006; 17:555-564.
15. Yamamoto J, Yamashita T, Ikarugi H, Taka T, Hashimoto M, Ishii H, et al. Gorog thrombosis test: a global in-vitro test of platelet function and thrombolysis. Blood Coagul Fibrinolysis 2003; 14:31-39.
16. Gorog DA, Saraf S, Salha IB, Sharma S, Saleem W. Measurement of clopidogrel resistance by ADP inhibition does not reflect the benefit of clopidogrel on overall thrombotic status. J Am Coll Cardiol 2008; 51:A335.
17. Kovacs IB, Tigyi-Sebes A, Trombitas K, Gorog P. Evans blue: an ideal energy-absorbing material to produce intravascular microinjury by He-Ne gas laser. Microvasc Res 1975; 10:107-124.
18. Ijiri Y, Miura M, Hashimoto M, Fukunaga C, Watanabe S, Kubota A, et al. A new model to evaluate the diet-induced prothrombotic status, using He-Ne laser-induced thrombogenesis in the carotid artery of apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Blood Coagul Fibrinolysis 2002; 13:497-504.
19. Panfili G, Manzi P, Pizzoferrato L. High-performance liquid chromatographic method for the simultaneous determination of tocopherols, carotenes, and retinol and its geometric isomers in Italian cheeses. Analyst 1994; 119:1161-1165.
20. Roe JH, Keuther CA. The determination of ascorbic acid in whole blood and urine through the 2,4-dinitrophenylhydrazine derivative of dehydroascorbic acid. J Biol Chem 1943; 147:399-407.
21. Gurbel PA, Bliden KP, DiChiara J, Newcomer J, Weng W, Neerchal NK, et al. Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) Study. Circulation 2007; 115:3156-3164.
22. Jilma B, Fuchs I. Detecting aspirin resistance with the platelet function analyzer (PFA-100). Am J Cardiol 2001; 88:1348-1349.
23. Kratzer MA, Storck K, Groh J. Prediction of the transfusion effect of platelet concentrates as measured by a model of primary hemostasis ex vivo. Haemostasis 1997; 27:99-104.
24. Chen WH, Lee PY, Ng W, Tse HF, Lau CP. Aspirin resistance is associated with a high incidence of myonecrosis after nonurgent percutaneous coronary intervention despite clopidogrel pretreatment. J Am Coll Cardiol 2004; 43:1122-1126.
25. Rivard GE, Brummel-Ziedins KE, Mann KG, Fan L, Hofer A, Cohen E. Evaluation of the profile of thrombin generation during the process of whole blood clotting as assessed by thromboelastography. J Thromb Haemost 2005; 3:2039-2043.
26. Naemura A, Ohira H, Ikeda M, Koshikawa K, Ishii H, Yamamoto J. An experimentally antithrombotic strawberry variety is also effective in humans. Pathophysiol Haemost Thromb 2006; 35:398-404.
27. Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001; 345:1583-1592.
28. Naemura A, Ura M, Yamashita T, Arai R, Yamamoto J. Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 2008; 122:517-522.