Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats

Journal of Neuroscience Research

Volumn 86, Issue 15, 2008, Pages 3410-3419

  Diaz Ruiz, Araceli ^a   Zavala, Carlos ^b   Montes, Sergio ^a   Ortiz Plata, Alma ^a   Salgado Ceballos, Hermelinda ^c   Orozco Suarez, Sandra ^c   Nava Ruiz, Concepción ^a   Pérez Neri, Iván ^a   Perez Severiano, Francisca ^a   Ríos, Camilo ^a  

^a NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

^b Hospital Regional de Alta Especialidad del Bajío León   (Mexico)

^c HOSPITAL DE ESPECIALIDADES   (Mexico)

Author keywords

Apoptosis; Dapsone; Ischemia reperfusion; Lipid peroxidation; Myeloperoxidase; Nitrotyrosine

Indexed keywords

3 NITROTYROSINE; CASPASE 3; CASPASE 9; DAPSONE; LIPID; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE MARKER; DRUG ANTAGONISM; DRUG MECHANISM; ENZYME ACTIVITY; INFLAMMATION; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; BRAIN ISCHEMIA; CASPASE 3; CASPASE 9; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DAPSONE; IMMUNOBLOTTING; IN SITU NICK-END LABELING; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; PEROXIDASE; RATS; RATS, WISTAR; REPERFUSION INJURY; TYROSINE;

EID: 57049169080     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21775     Document Type: Article

References (67)

1. Aronowski J, Cho KH, Strong R, Grotta JC. 1999. Neurofilament proteolysis after focal ischemia; when do cells die after experimental stroke? J Cereb Blood Flow Metab 19:652-660.
2. Bonney RJ, Humes JL. 1984. Physiological and pharmacological regulation of prostaglandin and leukotriene production by macrophages. J Leukoc Biol 35:1-10.
3. Bozeman PM, Learn DB, Thomas EL. 1992. Inhibition of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase by dapsone. Biochem Pharmacol 44:553-563.
4. Bramlett HM, Dietrich WD. 2004. Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J Cereb Blood Flow Metab 24:133-150.
5. Chan PH. 2004. Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia. Neurochem Res 29:1943-1949.
6. Chen J, Nagayama T, Jin K. Stetler RA, Zhu RL, Graham SH, Simon RP. 1998. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18:4914-4928.
7. Christophe M, Nicolas S. 2006. Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion. Curr Pharm Des 12:739-757.
8. Culmsee C, Krieglstein J. 2005. Mechanisms of neuronal degeneration alter ischemic stroke-emerging targets for novel therapeutic strategies. Drug Discov Today Dis Mech 2:463-470.
9. Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellecchia M, Blomgren K, Plesnila N. 2005. Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci 25:10262-10272.
10. Diringer MN, Edwards DF, Mattson DT, Akins PT, Sheedy CW, Hsu CY, Dromerick AW. 1999. Predictors of acute hospital costs for treatment of ischemic stroke in an academic center. Stroke 30:724-728.
11. Dirnagl U, Iadecola C, Moskowitz MA. 1999. Pathobiology of ischaemi stroke: an integrated view. Trends Neurosci 22:391-397.
12. Dodel RC, Haacke C, Zamzow K, Paweilik S, Spottke A, Rethfeldt M, Siebert U, Oertel WH, Schoffski O, Back T. 2004. Resource utilization and costs of stroke unit care in Germany. Value Health 7:144-152.
13. Eliasson MJ, Huang Z, Ferrante RJ, Sasamata M, Molliver ME, Snyder SH, Moskowitz MA. 1999. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage. J Neurosci 19:5910-5918.
14. Endres M, Namura S, Shimizu-Sasamata M, Waeber C, Zhang L, Gomez-Isla T, Hyman BT, Moskowitz MA. 1998. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab 18:238-247.
15. Fujikawa DG, Shinmei SS, Cai B. 1999. Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats. Eur J Neurosci 11:1605-1614.
16. Fujikawa DG, Shinmei SS, Cai B. 2000. Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanism. Neuroscience 98:41-53.
17. Ginsberg MD. 2003. Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture. Stroke 34:214-223.
18. Globus MY, Busto R, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. 1988. Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis. J Neurochem 51:1455-1464.
19. Hazen SL, Zhang R, Shen Z, Wu W, Podrez EA, MacPherson JC, Schmitt D, Mitra SN, Mukhopadhyay C, Chen Y, Cohen PA, Hoff HF, Abu-Soud HM. 1999. Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivo. Circ Res 85:950-958.
20. + exchange inhibitor SM-20220 attenuates leukocyte adhesion induced by ischemia-reperfusion. J Cardiovasc Pharmacol 37:668-677.
21. Huang J, Upadhyay UM, Tamargo RJ. 2006. Inflammation in stroke and focal cerebral ischemia. Surg Neurol 66:232-245.
22. Iversen LL, Glowinski J. 1966. Regional studies of catecholamines in the rat brain. II. Rate of turnover of catecholamines in various brain regions. J Neurochem 13:671-682.
23. Kato N, Yanaka K, Hyodo K, Homma K, Nagase S, Nose T. 2003. Stable nitroxide Tempol ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischemia. Brain Res 979:188-193.
24. Kaur H, Lyras L, Jenner P, Halliwell B. 1998. Artefacts in HPLC detection of 3-titrotyrosine in human brain tissue. J Neurochem 70:2220-2223.
25. Koopman G, Reutelingsperger CP, Kuijken GA, Keehen RM, Pals ST, van Oers MH. 1994. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415-1420.
26. Kristian T, Siesjo BK. 1998. Calcium in ischemic cell death. Stroke 29:705-718.
27. Kuschinsky W, Gillardon F. 2000. Apoptosis and cerebral ischemia. Cerebrovasc Dis 10:165-169.
28. Lau D, Baldus S. 2006. Myeloperoxidase and its contributory role in inflammatory vascular disease. Pharmacol Ther 11:16-26.
29. Lee J, Zipfel GJ, Choi DW. 1999. The changing landscape of ischaemic brain injury mechanisms. Nature 399:A7-A144.
30. Leker RR, Shohami E. 2002. Cerebral isquemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Brain Res Rev 39:55-73.
31. Leker RR, Aharonowiz M, Greig NH, Ovadia H. 2004. The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. Exp Neurol 187:478-486.
32. Leoung GS, Mills J, Hopewell PC, Hughes W, Wofsy C. 1986. Dapsone-trimethoprim for pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Ann Intern Med 105:45-48.
33. Leppik IE. 2004. Zonisamide: chemistry, mechanism of action, and pharmacokinetics. Seizure 13(Suppl 1):S5-S9; discussion S10.
34. Longa ZE, Weinstein PR, Carlson S, Cummins R. 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91.
35. MacManus JP, Buchan AM. 2000. Apoptosis after experimental stroke: fact orfashion? J Neurotrauma 17:899-914.
36. Maloff BL, Fox D, Bruin E, Di Meo TM. 1988. Dapsone inhibits LTB4 binding and bioresponse at the cellular and physiologic levels. Eur J Pharmacol 158:85-89.
37. Margail I, Plotkine M, Lerouet D. 2005. Antioxidant strategies in the treatment of stroke. Free Radic Biol Med 39:429-443.
38. Mehta SL, Manha N, Raghubir R. 2007. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Brain Res Rev (in press).
39. Melani A, Pantoni L, Corsi C, Bianchi L, Monopoli A, Bertorelli R, Pepeu G, Pedata F. 1999. Striatal out.ow of adenosine, excitatory amino acids, γ-aminobutyric acid and taurine in awake freely moving rats after middle cerebral artery occlusion. Stroke 30:2448-2455.
40. Nader-Kawachi J, Góngora-Rivera F, Santos-Zambrano J, Calzada P, Rios C. 2006. Neuroprotective effect of dapsone in patients with acute ischemic stroke: a pilot study. Neurol Res (in press).
41. Nakazawa H, Fukuyama N, Takizawa S, Tsuji C, Yoshitake M, Ishida H. 2000. Nitrotyrosine formation and its role in various pathological conditions. Free Radic Res 33:771-784.
42. Padosch SA, Bottiger BW. 2003. Neuronal apoptosis following cerebral ischaemia: pathophysiology and possible therapeutic implications. Curr Opin Anaesthesiol 16:439-445.
43. Parmentier S, Bohme GA, Lerouet D, Damour D, Stutzmann JM, Margaill I, Plotkine M. 1999. Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br J Pharmacol 127:546-552.
44. Petito CK, Torres-Munoz T, Roberts B, Olarte J, Nowak TS, Pulsinelli WA. 1997. DNA fragmentation follows delayed neuronal death in CA1 neurons exposed to transient global ischemia in the rat. J Cereb Blood Flow Metab 17:967-976.
45. Pisani A, Bonsi P, Calabresi P. 2004. Calcium signaling and neuronal vulnerability to ischemia in the striatum. Cell Calcium 36:277-284.
46. Porsdal V, Boysen G. 1999. Costs of health care and social services during the .rst year after ischemic stroke. Int J Technol Assess Health Care 15:573-584.
47. Portera-Cailliau C, Price DL, Martin LJ. 1997. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis continuum. J Comp Neurol 378:70-87.
48. Rios C, Nader-Kawachi J, Rodriguez-Payan AJ, Nava-Ruiz C. 2004. Neuroprotective effect of dapsone in an occlusive model of focal ischemia in rats. Brain Res 999:212-215.
49. Rodriguez E, Mendez-Armenta M, Villeda-Hernandez J, Galvan-Arzate S, Barroso-Moguel R, Rodriguez F, Rios C, Santamaria A. 1999. Dapsone prevents morphological lesions and lipid peroxidation induced by quinolinic acid in rat corpus striatum. Toxicology 139:111-118.
50. Santamaria A, Rios C. 1993. MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. Neurosci Lett 159:51-54.
51. Santamaria A, Ordaz-Moreno J, Rubio-Osornio M, Solis-Hernandez F, Rios C. 1997. Neuroprotective effect of dapsone against quinolinate-and kainate-induced striatal neurotoxicities in rats. Pharmacol Toxicol 81:271-275.
52. Santos MS, Moreno AJ, Carvalho AP. 1996. Relationships between ATP depletion, membrane potential, and the release of neurotransmitters in rat nerve terminals. An in vitro study under conditions that mimic anoxia, hypoglycemia, and ischemia. Stroke 27:941-950.
53. Shen J, Zhang H, Lin H, Su H, Xing D, Du L. 2007. Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression. Eur J Pharmacol 558:88-95.
54. Shirakura T, Han F, Shiota N, Moriguchi S, Kasahara J, Sato T, Shirasaki Y, Fukunaga K. 2005. Inhibition of nitric oxide production and protein tyrosine nitration contribute to neuroprotection by a novel calmodulin antagonist, DY-9760e, in the rat microsphere embolism. Biol Pharm Bull 28:1658-1661.
55. Spieler JF, Lanoe JL, Amarenco P. 2004. Costs of stroke care according to handicap levels and stroke subtypes. Cerebrovasc Dis 17:134-142.
56. Suda T, Suzuki Y, Matsui T, Inoue T, Niide O, Yoshimaru T, Suzuki H, Ra C, Ochiai T. 2005. Dapsone suppresses human neutrophil superoxide production and elastase release in a calcium-dependent manner. Br J Dermatol 152:887-895.
57. Takizawa S, Fukuyama N, Hirabayashi H, Nakazawa H, Shinohara Y. 1999. Dynamics of nitrotyrosine formation and decay in rat brain during focal ischemia-reperfusion. J Cereb Blood Flow Metab 19:667-672.
58. Thiyagarajan M, Sharma SS. 2004. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral isquemia in rats. Life Sci 74:969-985.
59. 2+ injection. J Neurochem 42:976-980.
60. Warner DS, Sheng H, Batinic-Haberle I. 2004. Oxidants, antioxidants and the ischemic brain. J Exp Biol 207:3221-3231.
61. Weaver M, Leshley K, Sands H, Gritman KR, Legos JJ, Tuma RF. 2002. LEX032, a novel recombinant serpin, protects the brain after transient focal ischemia. Microvasc Res 63:327-334.
62. White BC, Sullivan JM, DeGracia DJ, O'Neil BJ, Neumar RW, Grossman LI, Rafols JA, Krause GS. 2000. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci 179:1-33.
63. Willmot M, Gibson C, Gray L, Murphy S, Bath P. 2005. Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review. Free Radic Biol Med 39:412-25.
64. Wozel G, Blasum C, Winter C, Gerlach B. 1997. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. In.amm Res 46:420-422.
65. Yoneda Y, Uehara T, Yamasaki H, Kita Y, Tabuchi M, Mori E. 2003. Hospital based study of the care and cost of acute ischemic stroke in Japan. Stroke 34:718-24.
66. Zheng Z, Yenari MA. 2004. Post-ischemic inflammation: molecular mechanisms and therapeutic implications. Neurol Res 26:884-892.
67. Zhu YI, Stiller MJ. 2001. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol 45:420-434.