Inhibition of nitric oxide production and protein tyrosine nitration contribute to neuroprotection by a novel calmodulin antagonist, DY-9760e, in the rat microsphere embolism

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 9, 2005, Pages 1658-1661

  Shirakura, Takashi ^a   Han, Feng ^a   Shiota, Norifumi ^a   Moriguchi, Shigeki ^a   Kasahara, Jiro ^a   Sato, Toshiyuki ^b   Shirasaki, Yasufumi ^b   Fukunaga, Kohji ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Cerebral ischemia; Dy 9760e; Microsphere; Nitric oxide; Peroxynitrite

Indexed keywords

CALMODULIN INHIBITOR; DY 9760E; MICROSPHERE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EMBOLISM; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME INHIBITION; GERBIL; MALE; NEUROPROTECTION; NITRATION; NONHUMAN; RAT; REPERFUSION;

ANIMALS; BLOTTING, WESTERN; BRAIN; CALMODULIN; CEREBRAL INFARCTION; INDAZOLES; INJECTIONS, INTRAPERITONEAL; INTRACRANIAL EMBOLISM; MICRODIALYSIS; MICROSPHERES; NEOSTRIATUM; NEUROPROTECTIVE AGENTS; NITRATES; NITRIC OXIDE; RATS; TYROSINE;

EID: 24944499652     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.28.1658     Document Type: Article

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