Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)

Journal of Medicinal Chemistry

Volumn 45, Issue 13, 2002, Pages 2708-2719

  Francisco, Ma Elena Y ^a   Seltzman, Herbert H ^a   Gilliam, Anne F ^a   Mitchell, René A ^a   Rider, Sharyl L ^a   Pertwee, Roger G ^b   Stevenson, Lesley A ^b   Thomas, Brian F ^a  

^a RTI INTERNATIONAL   (United States)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; AMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HYDRAZIDE DERIVATIVE; N (MORPHOLIN 4 YL) 5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; N CYCLOHEXYL 5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; NITROGEN; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; HYDROGEN BOND; MALE; MOLECULAR INTERACTION; MOLECULAR SIZE; MOUSE; NONHUMAN; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; STEREOSPECIFICITY; SURFACE CHARGE;

ANIMALS; BINDING, COMPETITIVE; CANNABINOIDS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MICE; MODELS, MOLECULAR; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERIDINES; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; VAS DEFERENS;

EID: 0037142337     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010498v     Document Type: Article

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