Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: A novel series of CB1 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 12, 2007, Pages 4077-4084

  Boström, Jonas ^a   Berggren, Kristina ^a   Elebring, Thomas ^a   Greasley, Peter J ^a   Wilstermann, Michael ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Antagonist; Cannabinoid; Scaffold hopping; Shape matching

Indexed keywords

5 (4 CHLOROPHENYL) 6 (2,4 DICHLOROPHENYL)PYRAZINE 2 CARBOXYLIC ACID PIPERIDIN 1 YLAMIDE; 5,6 BIS(2 CHLOROPHENYL)PYRAZINE 2 CARBOXYLIC ACID CYCLOHEXYLAMIDE; 5,6 BIS(2 CHLOROPHENYL)PYRAZINE 2 CARBOXYLIC ACID PHENYLAMIDE; 5,6 BIS(2 CHLOROPHENYL)PYRAZINE 2 CARBOXYLIC ACID PIPERIDIN 1 YLAMIDE; 5,6 BIS(4 BROMOPHENYL)PYRAZINE 2 CARBOXYLIC ACID CYCLOHEXYLAMIDE; 5,6 BIS(4 BROMOPHENYL)PYRAZINE 2 CARBOXYLIC ACID PIPERIDIN 1 YLAMIDE; 5,6 BIS(4 CHLOROPHENYL)PYRAZINE 2 CARBOXYLIC ACID CYCLOHEXYLAMIDE; 5,6 BIS(4 CHLOROPHENYL)PYRAZINE 2 CARBOXYLIC ACID PHENYLAMIDE; 5,6 BIS(4 CHLOROPHENYL)PYRAZINE 2 CARBOXYLIC ACID PIPERIDIN 1 YLAMIDE; 5,6 BIS(4 METHOXYPHENYL)PYRAZINE 2 CARBOXYLIC ACID CYCLOHEXYLAMIDE; 5,6 BIS(4 METHOXYPHENYL)PYRAZINE 2 CARBOXYLIC ACID PHENYLAMIDE; 5,6 BIS(4 METHOXYPHENYL)PYRAZINE 2 CARBOXYLIC ACID PIPERIDIN 1 YLAMIDE; 5,6 DI 4 TOLYLPYRAZINE 2 CARBOXYLIC ACID CYCLOHEXYLAMIDE; 5,6 DI 4 TOLYLPYRAZINE 2 CARBOXYLIC ACID PHENYLAMIDE; 5,6 DI 4 TOLYLPYRAZINE 2 CARBOXYLIC ACID PIPERIDIN 1 YLAMIDE; 5,6 DIPHENYLPYRAZINE 2 CARBOXYLIC ACID PHENYLAMIDE; 5,6 DIPHENYLPYRAZINE 2 CARBOXYLIC ACID PIPERIDIN 1 YLAMIDE; 6 (4 CHLOROPHENYL) 5 (2,4 DICHLOROPHENYL)PYRAZINE 2 CARBOXYLIC ACID PIPERIDIN 1 YLAMIDE; AMIDE; CANNABINOID RECEPTOR ANTAGONIST; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); METHYLPYRAZOLE; PYRAZINE; PYRAZOLE DERIVATIVE; RIMONABANT; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; OBESITY; STRUCTURE ACTIVITY RELATION;

GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; PYRAZINES; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247884385     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.075     Document Type: Article

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