Age-dependent Wnt gene expression in bone and during the course of osteoblast differentiation

Age

Volumn 30, Issue 4, 2008, Pages 273-282

  Rauner, Martina ^a,b,c   Sipos, Wolfgang ^d   Pietschmann, Peter ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

Aging; Bone; Osteoblast; Wnt proteins

Indexed keywords

ALIZARIN RED S; DIFFKOPF 1 PROTEIN; LIPOPROTEIN RECEPTOR; MESSENGER RNA; PROTEIN DERIVATIVE; SCLEROSTIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 PROTEIN; WNT10B PROTEIN; WNT3A PROTEIN; WNT4 PROTEIN; WNT5A PROTEIN; WNT5B PROTEIN; WNT7B PROTEIN; WNT9B PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE; BONE MARROW CELL; BONE TISSUE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOLYSIS; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 56749183660     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-008-9069-9     Document Type: Article

References (28)

1. D Baksh RS Tuan 2007 Canonical and non-canonical Wnts differentially affect the development potential of primary isolate of human bone marrow mesenchymal stem cells J Cell Physiol 212 817 826
2. CN Bennett KA Longo WS Wright LJ Suva TF Lane KD Hankenson OA MacDougall 2005 Regulation of osteoblastogenesis and bone mass by Wnt10b Proc Natl Acad Sci USA 102 3324 3329
3. PV Bodine J Billiard RA Moran H Ponce-de-Leon S McLarney A Mangine MJ Scrimo RA Bhat B Stauffer J Green GS Stein JB Lian BS Komm 2005 The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis J Cell Biochem 96 1212 1230
4. GM Boland G Perkins DJ Hall RS Tuan 2004 Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells J Cell Biochem 93 1210 1230
5. AS Brack MJ Conboy S Roy M Lee CJ Kuo C Keller TA Rando 2007 Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis Science 317 807 810
6. SW Cho SJ Her HJ Sun OK Choi JY Yang SW Kim SY Kim CS Shin 2008 Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts Biochem Biophys Res Commun 367 399 405
7. BL Clarke PR Ebeling JD Jones HW Wahner WM O'Fallon BL Riggs AL Fitzpatrick 1996 Changes in quantitative bone histomorphometry in aging healthy men J Clin Endocrinol Metab 81 2264 2270
8. J de Boer R Siddappa C Gaspar A van Apeldoorn R Fodde C van Blitterswijk 2004 Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells Bone 34 818 826
9. NA Decarolis KA Wharton AJ Eisch 2008 Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging Bioessays 30 102 106
10. S Kang CN Bennett I Gerin LA Rapp KD Hankenson OA Macdougald 2007 Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma J Biol Chem 282 14515 14524
11. V Krishnan HU Bryant OA Macdougald 2006 Regulation of bone mass by Wnt signaling J Clin Invest 116 1202 1209
12. H Liu MM Fergusson RM Castilho J Liu L Cao J Chen D Malide II Rovira D Schimel CJ Kuo JS Gutkind PM Hwang T Finkel 2007 Augmented Wnt signaling in a mammalian model of accelerated aging Science 317 803 806
13. F Morvan K Boulukos P Clément-Lacroix S Roman Roman I Suc-Royer B Vayssière P Ammann P Martin S Pinho P Pognonec P Mollat C Niehrs R Baron G Rawadi 2006 Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass J Bone Miner Res 21 934 945
14. R Nakanishi M Shimizu M Mori H Akiyama S Okudaira B Otsuki M Hashimoto K Higuchi M Hosokawa T Tsuboyama T Nakamura 2006 Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice J Bone Miner Res 21 1713 1721
15. AM Parfitt 1979 Quantum concept of bone remodelling and turnover: implications for the pathogenesis of osteoporosis Calcif Tissue Int 28 1 5
16. AM Parfitt AR Villanueva J Foldes DS Rao 1995 Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis J Bone Miner Res 10 466 473
17. P Pietschmann M Skalicky M Kneissel M Rauner G Hofbauer D Stupphann A Viidik 2007 Bone structure and metabolism in a rodent model of male senile osteoporosis Exp Gerontol 42 1099 1108
18. KE Poole RL van Bezooijen N Loveridge H Hamersma SE Papapoulos CW Löwik J Reeve 2005 Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation FASEB J 19 1842 1844
19. M Rauner M Winzer D Stupphann D Krenbek P Pietschmann 2007 RANKL and OPG gene expression bone marrow stromal cells and calvarial osteoblasts in mouse and rat Osteologie 16 19 28
20. W Si Q Kang HH Luu JK Park Q Luo WX Song W Jiang X Luo X Li H Yin AG Montag RC Haydon TC He 2006 CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells Mol Cell Biol 26 2955 2964
21. W Sipos P Pietschmann M Rauner 2008 Strategies for novel therapeutic approaches targeting cytokines and signaling pathways of osteoclasto- and osteoblastogenesis in the fight against immune-mediated bone and joint diseases Curr Med Chem 15 127 136
22. I Takada M Mihara M Suzawa F Ohtake S Kobayashi M Igarashi MY Youn K Takeyama T Nakamura Y Mezaki S Takezawa Y Yogiashi H Kitagawa G Yamada S Takada Y Minami H Shibuya K Matsumoto S Kato 2007 A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation Nat Cell Biol 9 1273 1285
23. G van der Horst SM van der Werf H Farih-Sips RL van Bezooijen CW Löwik M Karperien 2005 Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells J Bone Miner Res 20 1867 1877
24. AM Vertino JM Taylor-Jones KA Longo ED Bearden TF Lane RE McGehee OA MacDougald CA Peterson 2005 Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts Mol Biol Cell 16 2039 2048
25. FS Wang CL Lin YJ Chen CJ Wang KD Yang YT Huang YC Sun HC Huang 2005 Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass Endocrinology 146 2415 2423
26. WHO Study Group (1994) Osteoporosis Working Group. WHO Technical Report Services 843:6
27. DG Winkler MK Sutherland JC Geoghegan C Yu T Hayes JE Skonier D Shpektor M Jonas BR Kovacevich K Staehling-Hampton M Appleby ME Brunkow JA Latham 2003 Osteocyte control of bone formation via sclerostin, a novel BMP antagonist EMBO J 22 6267 6276
28. Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, Leboff MS, Glowacki J (2008) Age-related intrinsic changes in human bone marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell 7:335-343