α4β1 integrin blockade after spinal cord injury decreases damage and improves neurological function

Experimental Neurology

Volumn 214, Issue 2, 2008, Pages 147-159

  Fleming, Jennifer C ^a,b   Bao, Feng ^a   Chen, Yuhua ^a   Hamilton, Eilis F ^a   Relton, Jane K ^b,c   Weaver, Lynne C ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c BiogenIdec   (United States)

Author keywords

Autonomic dysreflexia; Inflammation; Integrin; Macrophage; Mechanical allodynia; Neuroprotection; Neutrophil; Oxidative damage; Serotonin; Spinal cord injury

Indexed keywords

BLOCKING ANTIBODY; DICHLOROFLUORESCEIN; FREE RADICAL; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; MONOCLONAL ANTIBODY; MYELIN; MYELOPEROXIDASE; VERY LATE ACTIVATION ANTIGEN 4; NEUROPROTECTIVE AGENT; SEROTONIN;

ALLODYNIA; ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTONOMIC DYSREFLEXIA; BLOOD PRESSURE; CELL ACTIVATION; CELL MIGRATION; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; CONVALESCENCE; DRUG HALF LIFE; ENZYME ACTIVITY; FEMALE; HOMOGENATE; LEUKOCYTE; LIPID PEROXIDATION; MACROPHAGE; MALE; MONOCYTE; MOTOR PERFORMANCE; NERVE FIBER; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC NERVE CELL; SPINAL CORD INJURY; TISSUE INJURY; WHITE MATTER; ACUTE DISEASE; ANIMAL; CELL COUNT; CELL MOTION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; METABOLISM; MOTOR ACTIVITY; NEURALGIA; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; SPINAL CORD; WISTAR RAT;

ACUTE DISEASE; ANIMALS; ANTIBODIES, MONOCLONAL; AXONS; CELL COUNT; CELL MOVEMENT; FEMALE; INTEGRIN ALPHA4BETA1; MACROPHAGES; MALE; MONOCYTES; MOTOR ACTIVITY; NEURALGIA; NEUROPROTECTIVE AGENTS; NEUTROPHILS; OXIDATIVE STRESS; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SEROTONIN; SPINAL CORD; SPINAL CORD INJURIES;

EID: 56749170671     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.04.024     Document Type: Article

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