The role of interleukin-12 in the heavy metal-elicited immunomodulation: Relevance of various evaluation methods

Journal of Occupational Medicine and Toxicology

Volumn 3, Issue 1, 2008, Pages

  Hemdan, Nasr Ya ^a,b,c  

^a FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c Alexandria University Faculty Of Science   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

MUS; SALMONELLA ENTERICA;

EID: 56749103693     PISSN: None     EISSN: 17456673     Source Type: Journal    
DOI: 10.1186/1745-6673-3-25     Document Type: Article

References (60)

1. Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). G Bertin D Averbeck, Biochimie 2006 88 1549 1559 10.1016/j.biochi.2006.10.001 17070979
2. Molecular mechanisms triggered by mercury. G Guzzi CA La Porta, Toxicology 2008 244 1 12 10.1016/j.tox.2007.11.002 18077077
3. Mechanisms of mercury disposition in the body. TW Clarkson JB Vyas N Ballatori, Am J Ind Med 2007 50 757 764 10.1002/ajim.20476 17477364
4. The toxicology of mercury and its chemical compounds. TW Clarkson L Magos, Crit Rev Toxicol 2006 36 609 662 10.1080/10408440600845619 16973445
5. Subchronic treatment with mercuric chloride suppresses immune response, elicits behavioral deficits and increases brain serotonin and dopamine metabolism in rats. H Naz N Baig S Haider DJ Haleem, Pak J Pharm Sci 2008 21 7 11 18166511
6. The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. MC Houston, Altern Ther Health Med 2007 13 S128 S133 17405690
7. Cadmium: toxic effects on the reproductive system and the embryo. J Thompson J Bannigan, Reprod Toxicol 2008 25 304 315 10.1016/j.reprotox.2008.02. 001 18367374
8. Cadmium-induced cancers in animals and in humans. J Huff RM Lunn MP Waalkes L Tomatis PF Infante, Int J Occup Environ Health 2007 13 202 212 17718178
9. Environmental exposure to mercury and its toxicopathologic implications for public health. PB Tchounwou WK Ayensu N Ninashvili D Sutton, Environ Toxicol 2003 18 149 175 10.1002/tox.10116 12740802
10. Effects of heavy metal ions on resting and antigen-activated CD4(+) T cells. X Shen K Lee R Konig, Toxicology 2001 169 67 80 10.1016/S0300-483X(01) 00483-8 11696410
11. Immune consequences of pediatric and adult cardiovascular surgery: report of the 7th Leipzig workshop. A Tarnok F Emmrich, Cytometry B Clin Cytom 2003 54 54 57 10.1002/cyto.b.10018 12827668
12. Cytometric bead array: a multiplexed assay platform with applications in various areas of biology. E Morgan R Varro H Sepulveda JA Ember J Apgar J Wilson, Clinical Immunology 2004 110 252 266 10.1016/j.clim.2003.11.017 15047203
13. Analysis of individual data from bead-based assays ("bead arrays"). JW Jacobson KG Oliver C Weiss J Kettman, Cytometry A 2006 69 384 390 16615139
14. Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients. C Prunet T Montange A Vejux A Laubriet JF Rohmer JM Riedinger, Cytometry A 2006 69 359 373 16604541
15. Multiplex analysis of cytokines in exhaled breath condensate. U Sack R Scheibe M Wotzel S Hammerschmidt H Kuhn F Emmrich, Cytometry A 2006 69 169 172 16496377
16. A combined HIV-1 protein bead array for serology assay and T-cell subset immunophenotyping with a hybrid flow cytometer: a step in the direction of a comprehensive multitasking instrument platform for infectious disease diagnosis and monitoring. S Faucher A Martel A Sherring D Bogdanovic L Malloch JE Kim, Cytometry B Clin Cytom 2006 70 179 188 16615079
17. An analytical workflow for investigating cytokine profiles. JC Siebert M Inokuma DM Waid ND Pennock GM Vaitaitis ML Disis, Cytometry A 2008 73 289 298 18163472
18. The expanding universe of T-cell subsets: Th1, Th2 and more. TR Mosmann S Sad, Immunology Today 1996 17 138 146 10.1016/0167-5699(96)80606-2 8820272
19. Human TH1 and TH2 subsets: doubt no more. S Romagnani, Immunol Today 1991 12 256 257 10.1016/0167-5699(91)90120-I 1680337
20. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. TR Mosmann RL Coffman, Annu Rev Immunol 1989 7 145 173 10.1146/annurev.iy.07.040189.001045 2523712
21. The role of IL-10 in crossregulation of TH1 and TH2 responses. TR Mosmann KW Moore, Immunol Today 1991 12 A49 A53 10.1016/S0167-5699(05)80015-5 1648926
22. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. HM Cherwinski JH Schumacher KD Brown TR Mosmann, J Exp Med 1987 166 1229 1244 2960769 10.1084/jem.166.5.1229
23. IL-6 Is Required for the Development of Th1 Cell-Mediated Murine Colitis. M Yamamoto K Yoshizaki T Kishimoto H Ito, J Immunol 2000 164 4878 4882 10779797
24. The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. RA Seder WE Paul MM Davis B Fazekas de St Groth, J Exp Med 1992 176 1091 1098 1328464 10.1084/jem.176.4.1091
25. Functional diversity of helper T lymphocytes. AK Abbas KM Murphy A Sher, Nature 1996 383 787 793 10.1038/383787a0 8893001
26. Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways. NY Hemdan I Lehmann G Wichmann J Lehmann F Emmrich U Sack, Clin Exp Immunol 2007 148 325 337 17302730 10.1111/j.1365-2249.2007.03338. x
27. Regulation of Protective and Pathogenic Th17 Responses. G Alber T Kamradt, curr immunol rev 2007 3 3 16 10.2174/157339507779802223
28. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. A Taylor J Verhagen K Blaser M Akdis CA Akdis, Immunology 2006 117 433 442 16556256 10.1111/j.1365-2567. 2006.02321.x
29. TGF-[beta], a 'double agent' in the immune pathology war. DJ Cua RA Kastelein, Nat Immunol 2006 7 557 559 10.1038/ni0606-557 16715066
30. TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells. M Veldhoen B Stockinger, Trends Immunol 2006 27 358 361 10.1016/j.it.2006.06.001 16793343
31. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. M Veldhoen RJ Hocking CJ Atkins RM Locksley B Stockinger, Immunity 2006 24 179 189 10.1016/j.immuni.2006.01.001 16473830
32. Microbial lipopeptides induce the production of IL-17 in Th cells. C Infante-Duarte HF Horton MC Byrne T Kamradt, J Immunol 2000 165 6107 6115 11086043
33. Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi! CM Tato A Laurence JJ O'Shea, J Exp Med 2006 203 809 812 16606679 10.1084/jem.20060522
34. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. C Heufler F Koch U Stanzl G Topar M Wysocka G Trinchieri, Eur J Immunol 1996 26 659 668 10.1002/eji.1830260323 8605935
35. Interleukin-12 promotes enhanced resistance to Listeria monocytogenes infection of lead-exposed mice. H Kishikawa R Song DA Lawrence, Toxicol Appl Pharmacol 1997 147 180 189 10.1006/taap.1997.8308 9439714
36. Treatment of Brucella-susceptible mice with IL-12 increases primary and secondary immunity. J Sathiyaseelan R Goenka M Parent RM Benson EA Murphy DM Fernandes, Cellular Immunology 2006 243 1 9 10.1016/j.cellimm.2006.10.003 17184756
37. Role of interleukin-12 in the maturation of naive human CD4 T cells. G Delespesse LP Yang U Shu DG Byun CE Demeure Y Ohshima, Ann N Y Acad Sci 1996 795 196 201 10.1111/j.1749-6632.1996.tb52668.x 8958930
38. VACUTAINER CPT and Ficoll density gradient separation perform equivalently in maintaining the quality and function of PBMC from HIV seropositive blood samples. JJ Ruitenberg CB Mulder VC Maino AL Landay SA Ghanekar, BMC Immunol 2006 7 11 16725038 10.1186/1471-2172-7-11
39. Lymphocyte subpopulations in human exposure to metals (IUPAC Technical Report). M Schwenk R Klein DM Templeton, Pure and Applied Chemistry 2008 80 1349 1364 10.1351/pac200880061349
40. Cytometric bead array to measure six cytokines in twenty-five microliters of serum. A Tarnok J Hambsch R Chen R Varro, Clin Chem 2003 49 1000 1002 10.1373/49.6.1000 12766012
41. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. MW Pfaffl GW Horgan L Dempfle, Nucleic Acids Res 2002 30 e36 11972351 10.1093/nar/30.9.e36
42. The in vitro immune modulation by cadmium depends on the way of cell activation. NY Hemdan F Emmrich U Sack G Wichmann J Lehmann K Adham, Toxicology 2006 222 37 45 10.1016/j.tox.2006.01.026 16510232
43. Alterations of Th1/Th2 Reactivity by Heavy Metals. Possible Consequences Include Induction of Autoimmune Diseases. NY Hemdan F Emmrich S Faber J Lehmann U Sack, Ann NY Acad Sci 2007 1109 129 137 10.1196/annals.1398.015 17785298
44. Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity. G Trinchieri, Annu Rev Immunol 1995 13 251 276 7612223
45. Role of interleukin-12 in human Th1 response. G Trinchieri, Chem Immunol 1996 63 14 29 8934829
46. IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection. A Mencacci E Cenci G Del Sero C Fé d'Ostiani P Mosci G Trinchieri, J Immunol 1998 161 6228 6237 9834110
47. Lead intoxication impairs the generation of a delayed type hypersensitivity response. MJ McCabe Jr KP Singh JJ Reiners Jr, Toxicology 1999 139 255 264 10.1016/S0300-483X(99)00147-X 10647925
48. Role of IFN-alpha/beta and IL-12 in the activation of natural killer cells and interferon-gamma production during experimental infection with Trypanosoma cruzi. C Une J Andersson A Orn, Clinical and Experimental Immunology 2003 134 195 201 10.1046/j.1365-2249.2003.02294.x
49. IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J Lehmann S Bellmann C Werner R Schroder N Schutze G Alber, J Immunol 2001 167 5304 5315 11673546
50. Immunity induced with a Salmonella enterica serovar Enteritidis live vaccine is regulated by Th1-cell-dependent cellular and humoral effector mechanisms in susceptible BALB/c mice. J Lehmann S Springer CE Werner T Lindner S Bellmann RK Straubinger, Vaccine 2006 24 4779 4793 10.1016/j.vaccine.2006.03. 024 16647169
51. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. F Sallusto D Lenig R Forster M Lipp A Lanzavecchia, Nature 1999 401 708 712 10.1038/44385 10537110
52. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. W Ouyang SH Ranganath K Weindel D Bhattacharya TL Murphy WC Sha, Immunity 1998 9 745 755 10.1016/S1074-7613(00)80671-8 9846495
53. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. W Zheng RA Flavell, Cell 1997 89 587 596 10.1016/S0092-8674(00)80240-8 9160750
54. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. M Bix RM Locksley, Science 1998 281 1352 1354 10.1126/science.281. 5381.1352 9721100
55. Cutting edge: stable epigenetic inheritance of regional IFN-gamma promoter demethylation in CD44highCD8+ T lymphocytes. DR Fitzpatrick KM Shirley A Kelso, J Immunol 1999 162 5053 5057 10227972
56. Mice lacking IL-12 develop polarized Th1 cells during viral infection. VE Schijns BL Haagmans CM Wierda B Kruithof IA Heijnen G Alber, J Immunol 1998 160 3958 3964 9558103
57. The neglected role of type I interferon in the T-cell response: implications for its clinical use. F Belardelli I Gresser, Immunol Today 1996 17 369 372 10.1016/0167-5699(96)10027-X 8783497
58. MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. S Shi C Nathan D Schnappinger J Drenkow M Fuortes E Block, J Exp Med 2003 198 987 997 14517275 10.1084/jem.20030603
59. T-cell Control of IL-12p75 Production. K Abdi N Singh P Matzinger, Scandinavian Journal of Immunology 2006 64 83 92 10.1111/j.1365-3083.2006.01767. x 16867152
60. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. D Jankovic MC Kullberg S Hieny P Caspar CM Collazo A Sher, Immunity 2002 16 429 439 10.1016/S1074-7613(02)00278-9 11911827