Role of IFN-α/β and IL-12 in the activation of natural killer cells and interferon-γ production during experimental infection with Trypanosoma cruzi

Clinical and Experimental Immunology

Volumn 134, Issue 2, 2003, Pages 195-201

  Une, C ^a   Andersson, J ^a   Orn A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

IFN ; IFN ; IL 12; NK cell; Trypanosoma cruzi

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; NITRIC OXIDE; RNA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; EXPERIMENTAL INFECTION; HOST RESISTANCE; IMMUNE RESPONSE; MOUSE; NATURAL KILLER CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTOZOAL INFECTION; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; CHAGAS DISEASE; CYTOTOXICITY, IMMUNOLOGIC; INTERFERON TYPE I; INTERFERON TYPE II; INTERLEUKIN-12; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL; NITRIC OXIDE; POLYMERASE CHAIN REACTION; SPLEEN;

EID: 0242606062     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02294.x     Document Type: Article

References (40)

1. Rottenberg M, Cardoni R, Andersson R, Segura E, Örn A. Role of T helper/inducer cells as well as natural killer cells in the resistance to Trypanosoma cruzi infection. Scand J Immunol 1988; 28:573.
2. Aliberti J, Cardoso M, Martins G, Gazzinelli R, Vieira L, Silva J. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect Immun 1996; 64:1961-7.
3. James SL, Kipnis TL, Sher A, Hoff R. Enhanced resistance to acute infection with Trypanosoma cruzi in mice treated with an interferon inducer. Infect Immun 1982; 35:588-93.
4. Cardillo F, Voltarelli J, Reed S, Silva J. Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin-10: role of NK cells. Infect Immun 1996; 64:128-34.
5. Trinchieri G. Biology of natural killer cells. Adv Immunol 1989; 47:187.
6. Cousens L, Orange J, Su H, Biron C. Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. PNAS 1997; 94:634-9.
7. Orange J, Biron C. Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol 1996; 156:4746-56.
8. + NK cells by HLA-B7 variants and target cells. J Immunol 1998; 160:1573-80.
9. Rajagopalan S, Fu J, Long EO. Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J Immunol 2001; 167:1877-81.
10. Une C, Andersson J, Eloranta M-L, Sunnemark D, Harris R, Örn A. Enhancement of natural killer cell cytotoxicity and induction of NK cell derived IFN-γ display different kinetics during experimental infection with Trypanosoma cruzi. Clin Exp Immunol 2000; 121:499-505.
11. Hatcher F, Kühn R, Cerrone M, Burton R. Increased natural killer cell activity in experimental American trypanosomiasis. J Immunol 1981; 127:1126-30.
12. Reed S, Brownell C, Russo D, Silva J, Grabstein K, Morrissey P. IL-10 mediates susceptibility to Trypanosoma cruzi infection. J Immunol 1994; 153:3135-40.
13. Gidlund M, Örn A, Wigzell H, Senik A, Gresser I. Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature 1978; 273:759-61.
14. Hunter C, Gabriel K, Radzanowski T, Neyer L, Remington J. Type I interferons enhance production of IFN-γ by NK cells. Immunol Lett 1997; 59:1-5.
15. Diefenbach A, Schindler H, Donhauser N et al. Type 1 interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 1998; 8:77-87.
16. Matikainen S, Paananen A, Miettinen M et al. IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12. Eur J Immunol 2001; 31:2236-45.
17. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13:251-76.
18. Scharton-Kersten T, Afonso L, Wysocka M, Trinchieri G, Scott P. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol 1995; 154:5320-30.
19. Scharton-Kersten T, Caspar P, Sher A, Denkers E. Toxoplasma gondii. Evidence for interleukin-12-dependent and -independent pathways of interferon-γ production induced by an attenuated parasite strain. Exp Parasitol 1996; 84:102-14.
20. Muller U, Kohler G, Mossmann H et al. IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18. J Immunol 2001; 167:3346-53.
21. Magram J, Connaughton SE, Warrier RR et al. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 1996; 4:471-81.
22. Muller U, Steinhoff U, Reis LF et al. Functional role of type I and type II interferons in antiviral defense. Science 1994; 264:1918-21.
23. Ullberg M, Jondal M. Recycling and target binding capacity of human natural killer cells. J Exp Med 1981; 153:615-28.
24. Laucella S, Salcedo R, Castaños-Velez E et al. Increased expression and secretion of ICAM-1 during experimental infection with Trypanosoma cruzi. Parasite Immunol 1996; 18:227-39.
25. Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 1988; 141:2407-12.
26. Gilliam MB, Sherman MP, Griscavage JM, Ignarro LJ: A spectrophotometric assay for nitrate using NADPH oxidation by Aspergillus nitrate reductase. Anal Biochem 1993; 212:359-65.
27. Reed SG. In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. J Immunol 1988; 140:4342-7.
28. Munoz-Fernandez MA, Fernandez MA, Fresno M. Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur J Immunol 1992; 22:301-7.
29. Hölscher C, Kohler G, Muller U, Mossmann H, Schaub GA, Brombacher F. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun 1998; 66:1208-15.
30. Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 1999; 17:189-220.
31. Antunez MI, Cardoni RL. Early IFN-gamma production is related to the presence of interleukin (IL)-18 and the absence of IL-13 in experimental Trypanosoma cruzi infections. Immunol Lett 2001; 79:189-96.
32. Reed SG. Immunology of Trypanosoma cruzi infections. Chem Immunol 1998; 70:124-43.
33. + T cell function to immune control of Trypanosoma cruzi. Parasite Immunol 1998; 20:207-16.
34. Nickell SP, Sharma D. Trypanosoma cruzi: roles for perforin-dependent and perforin-independent immune mechanisms in acute resistance. Exp Parasitol 2000; 94:207-16.
35. Rottenberg M, Riarte A, Sporrong L et al. Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8. Immunol Lett 1995; 45:53.
36. + T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi. J Immunol 1990; 144:717-24.
37. + cells and T-cell activation in euthymic and thymectomized C57B1/6 mice during acute Trypanosoma cruzi infection. Scand J Immunol 2002; 55:96-104.
38. Duthie MS, Wleklinski-Lee M, Smith S, Nakayama T, Taniguchi M, Kahn SJ. During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein. Infect Immun 2002; 70:36-48.
39. Carnaud C, Lee D, Donnars O et al. Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol 1999; 163:4647-50.
40. Miyahira Y, Katae M, Takeda K et al. Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun 2003; 71:1234-41.