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Volumn 21, Issue 12, 2008, Pages 1527-1532

Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: A potential therapeutic target

Author keywords

Breast carcinoma; FoxP3; Prognostic indicators; Regulatory T cells

Indexed keywords

ANTIBODY; ESTROGEN RECEPTOR ANTIBODY; FOXP3 ANTIBODY; HER2 ANTIBODY; HORMONE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 56649102194     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2008.160     Document Type: Article
Times cited : (127)

References (41)
  • 1
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 2
    • 33746342994 scopus 로고    scopus 로고
    • Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
    • Sakaguchi S, Ono M, Setoguchi R, et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006;212:8-27.
    • (2006) Immunol Rev , vol.212 , pp. 8-27
    • Sakaguchi, S.1    Ono, M.2    Setoguchi, R.3
  • 4
    • 45849153869 scopus 로고    scopus 로고
    • Coordination of early protective immunity to viral infection by regulatory T Cells
    • Lund JM, Hsing L, Pham TT, et al. Coordination of early protective immunity to viral infection by regulatory T Cells. Science 2008;320:1168-1169.
    • (2008) Science , vol.320 , pp. 1168-1169
    • Lund, J.M.1    Hsing, L.2    Pham, T.T.3
  • 5
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 6
    • 33845542866 scopus 로고    scopus 로고
    • Regulating regulatory T cells
    • Le NT, Chao N. Regulating regulatory T cells. Bone Marrow Transplant 2007;39:1-9.
    • (2007) Bone Marrow Transplant , vol.39 , pp. 1-9
    • NT, L.1    Chao, N.2
  • 7
    • 0034544532 scopus 로고    scopus 로고
    • A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response
    • Dunbar PR, Smith CL, Chao D, et al. A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response. J Immunol 2000;165:6644-6652.
    • (2000) J Immunol , vol.165 , pp. 6644-6652
    • Dunbar, P.R.1    Smith, C.L.2    Chao, D.3
  • 8
    • 0033056073 scopus 로고    scopus 로고
    • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
    • Lee PP, Yee C, Savage PA, et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med 1999;5:677-685.
    • (1999) Nat Med , vol.5 , pp. 677-685
    • Lee, P.P.1    Yee, C.2    Savage, P.A.3
  • 9
    • 0032476616 scopus 로고    scopus 로고
    • Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes
    • Romero P, Dunbar PR, Valmori D, et al. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes. J Exp Med 1998;188:1641-1650.
    • (1998) J Exp Med , vol.188 , pp. 1641-1650
    • Romero, P.1    Dunbar, P.R.2    Valmori, D.3
  • 10
    • 0035421798 scopus 로고    scopus 로고
    • Mature dendritic cells prime functionally superior melan-A-specific CD8+ lymphocytes as compared with nonprofessional APC
    • Salio M, Shepherd D, Dunbar PR, et al. Mature dendritic cells prime functionally superior melan-A-specific CD8+ lymphocytes as compared with nonprofessional APC. J Immunol 2001;167:1188-1197.
    • (2001) J Immunol , vol.167 , pp. 1188-1197
    • Salio, M.1    Shepherd, D.2    Dunbar, P.R.3
  • 11
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel TJ, Wei S, Dong H, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003;9:562-567.
    • (2003) Nat Med , vol.9 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3
  • 12
    • 0142250482 scopus 로고    scopus 로고
    • Bach JF. Regulatory T cells under scrutiny. Nat Rev Immunol 2003;3:189-198.
    • Bach JF. Regulatory T cells under scrutiny. Nat Rev Immunol 2003;3:189-198.
  • 13
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-949.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 14
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4(+)CD25(+) Tcells with regulatory properties from human blood
    • Dieckmann D, Plottner H, Berchtold S, et al. Ex vivo isolation and characterization of CD4(+)CD25(+) Tcells with regulatory properties from human blood. J Exp Med 2001;193:1303-1310.
    • (2001) J Exp Med , vol.193 , pp. 1303-1310
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3
  • 15
    • 0035806323 scopus 로고    scopus 로고
    • Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings MK, Sangregorio R, Roncarolo MG. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001;193:1295-1302.
    • (2001) J Exp Med , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 16
    • 0035525739 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) cells: A naturally occurring population of regulatory T cells
    • Ng WF, Duggan PJ, Ponchel F, et al. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 2001;98:2736-2744.
    • (2001) Blood , vol.98 , pp. 2736-2744
    • Ng, W.F.1    Duggan, P.J.2    Ponchel, F.3
  • 17
    • 0035546070 scopus 로고    scopus 로고
    • CD4(+) regulatory T cells
    • Read S, Powrie F. CD4(+) regulatory T cells. Curr Opin Immunol 2001;13:644-649.
    • (2001) Curr Opin Immunol , vol.13 , pp. 644-649
    • Read, S.1    Powrie, F.2
  • 18
    • 0036597371 scopus 로고    scopus 로고
    • CD4+ CD25+ suppressor T cells: More questions than answers
    • Shevach EM. CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2002;2:389-400.
    • (2002) Nat Rev Immunol , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 19
    • 0037361819 scopus 로고    scopus 로고
    • Antigen-induced regulatory T cells in autoimmunity
    • von Herrath MG, Harrison LC. Antigen-induced regulatory T cells in autoimmunity. Nat Rev Immunol 2003;3:223-232.
    • (2003) Nat Rev Immunol , vol.3 , pp. 223-232
    • von Herrath, M.G.1    Harrison, L.C.2
  • 20
    • 0037364976 scopus 로고    scopus 로고
    • Regulatory T cells in transplantation tolerance
    • Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003;3:199-210.
    • (2003) Nat Rev Immunol , vol.3 , pp. 199-210
    • Wood, K.J.1    Sakaguchi, S.2
  • 21
    • 34247261531 scopus 로고    scopus 로고
    • Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    • Bates GJ, Fox SB, Han C, et al. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol 2006;24:5373-5380.
    • (2006) J Clin Oncol , vol.24 , pp. 5373-5380
    • Bates, G.J.1    Fox, S.B.2    Han, C.3
  • 22
    • 0141891466 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers
    • Ichihara F, Kono K, Takahashi A, et al. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin Cancer Res 2003;9:4404-4408.
    • (2003) Clin Cancer Res , vol.9 , pp. 4404-4408
    • Ichihara, F.1    Kono, K.2    Takahashi, A.3
  • 23
    • 3142737258 scopus 로고    scopus 로고
    • Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells
    • Viguier M, Lemaitre F, Verola O, et al. Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J Immunol 2004;173:1444-1453.
    • (2004) J Immunol , vol.173 , pp. 1444-1453
    • Viguier, M.1    Lemaitre, F.2    Verola, O.3
  • 24
    • 42049111164 scopus 로고    scopus 로고
    • FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy
    • Ghebeh H, Barhoush E, Tulbah A, et al. FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: implication for immunotherapy. BMC Cancer 2008;8:57.
    • (2008) BMC Cancer , vol.8 , pp. 57
    • Ghebeh, H.1    Barhoush, E.2    Tulbah, A.3
  • 25
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991;19:403-410.
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 26
    • 49249105900 scopus 로고    scopus 로고
    • FOXP3 immunohistochemistry on formalin-fixed paraffin embedded tissue- poor correlation between different antibodies
    • Woo YL, Sterling JC, Crawford RA, et al. FOXP3 immunohistochemistry on formalin-fixed paraffin embedded tissue- poor correlation between different antibodies. J Clin Pathol 2008;61:969-971.
    • (2008) J Clin Pathol , vol.61 , pp. 969-971
    • Woo, Y.L.1    Sterling, J.C.2    Crawford, R.A.3
  • 27
    • 20844432429 scopus 로고    scopus 로고
    • Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
    • Roncador G, Brown PJ, Maestre L, et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005;35:1681-1691.
    • (2005) Eur J Immunol , vol.35 , pp. 1681-1691
    • Roncador, G.1    Brown, P.J.2    Maestre, L.3
  • 28
    • 0027448803 scopus 로고
    • Tumor necrosis is a prognostic predictor for early recurrence and death in lymph node-positive breast cancer: A 10-year follow-up study of 728 Eastern Cooperative Oncology Group patients
    • Gilchrist KW, Gray R, Fowble B, et al. Tumor necrosis is a prognostic predictor for early recurrence and death in lymph node-positive breast cancer: a 10-year follow-up study of 728 Eastern Cooperative Oncology Group patients. J Clin Oncol 1993;11:1929-1935.
    • (1993) J Clin Oncol , vol.11 , pp. 1929-1935
    • Gilchrist, K.W.1    Gray, R.2    Fowble, B.3
  • 29
    • 0018629819 scopus 로고
    • Long-term survival of patients with breast cancer: A study of the curability of the disease
    • Langlands AO, Pocock SJ, Kerr GR, et al. Long-term survival of patients with breast cancer: a study of the curability of the disease. Br Med J 1979;2:1247-1251.
    • (1979) Br Med J , vol.2 , pp. 1247-1251
    • Langlands, A.O.1    Pocock, S.J.2    Kerr, G.R.3
  • 30
    • 0025892748 scopus 로고
    • Factors predicting late mortality from breast cancer
    • Toikkanen SP, Kujari HP, Joensuu H. Factors predicting late mortality from breast cancer. Eur J Cancer 1991;27:586-591.
    • (1991) Eur J Cancer , vol.27 , pp. 586-591
    • Toikkanen, S.P.1    Kujari, H.P.2    Joensuu, H.3
  • 31
    • 42249115188 scopus 로고    scopus 로고
    • Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells
    • Ladoire S, Arnould L, Apetoh L, et al. Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells. Clin Cancer Res 2008;14:2413-2420.
    • (2008) Clin Cancer Res , vol.14 , pp. 2413-2420
    • Ladoire, S.1    Arnould, L.2    Apetoh, L.3
  • 32
    • 36849053106 scopus 로고    scopus 로고
    • FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2
    • Zuo T, Liu R, Zhang H, et al. FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J Clin Invest 2007;117:3765-3773.
    • (2007) J Clin Invest , vol.117 , pp. 3765-3773
    • Zuo, T.1    Liu, R.2    Zhang, H.3
  • 33
    • 38049064586 scopus 로고    scopus 로고
    • Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer
    • Mizukami Y, Kono K, Kawaguchi Y, et al. Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer. Br J Cancer 2008;98:148-153.
    • (2008) Br J Cancer , vol.98 , pp. 148-153
    • Mizukami, Y.1    Kono, K.2    Kawaguchi, Y.3
  • 34
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity
    • Shimizu J, Yamazaki S, Sakaguchi S. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999;163:5211-5218.
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 35
    • 0035893387 scopus 로고    scopus 로고
    • Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma
    • Steitz J, Bruck J, Lenz J, et al. Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma. Cancer Res 2001;61:8643-8646.
    • (2001) Cancer Res , vol.61 , pp. 8643-8646
    • Steitz, J.1    Bruck, J.2    Lenz, J.3
  • 36
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller RP, van Duivenvoorde LM, van Elsas A, et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001;194:823-832.
    • (2001) J Exp Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.1    van Duivenvoorde, L.M.2    van Elsas, A.3
  • 37
    • 0036093489 scopus 로고    scopus 로고
    • Depletion of CD4+ CD25+ regulatory cells augments the generation of specific immune T cells in tumor-draining lymph nodes
    • Tanaka H, Tanaka J, Kjaergaard J, et al. Depletion of CD4+ CD25+ regulatory cells augments the generation of specific immune T cells in tumor-draining lymph nodes. J Immunother 2002;25:207-217.
    • (2002) J Immunother , vol.25 , pp. 207-217
    • Tanaka, H.1    Tanaka, J.2    Kjaergaard, J.3
  • 38
    • 33745306869 scopus 로고    scopus 로고
    • IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice
    • Knutson KL, Dang Y, Lu H, et al. IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice. J Immunol 2006;177:84-91.
    • (2006) J Immunol , vol.177 , pp. 84-91
    • Knutson, K.L.1    Dang, Y.2    Lu, H.3
  • 39
    • 0034280315 scopus 로고    scopus 로고
    • (389)IL-2 (ONTAK): A novel fusion toxin therapy for lymphoma
    • Foss FM. DAB(389)IL-2 (ONTAK): a novel fusion toxin therapy for lymphoma. Clin Lymphoma 2000;1:110-116.
    • (2000) Clin Lymphoma , vol.1 , pp. 110-116
    • Foss, F.D.1
  • 40
    • 34248194231 scopus 로고    scopus 로고
    • Tregs and rethinking cancer immunotherapy
    • Curiel TJ. Tregs and rethinking cancer immunotherapy. J Clin Invest 2007;117:1167-1174.
    • (2007) J Clin Invest , vol.117 , pp. 1167-1174
    • Curiel, T.J.1
  • 41
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • Attia P, Phan GQ, Maker AV, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 2005;23:6043-6053.
    • (2005) J Clin Oncol , vol.23 , pp. 6043-6053
    • Attia, P.1    Phan, G.Q.2    Maker, A.V.3


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