Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1G93A-transgenic mice

Neuroscience

Volumn 157, Issue 4, 2008, Pages 844-849

  Rohde, G ^a,b   Kermer, P ^a,b   Reed, J C ^c   Bahr M ^a,b   Weishaupt, J H ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Deutsche Forschungsgemeinschaft   (Germany)

^c BURNHAM INSTITUTE   (United States)

Author keywords

aggregopathy; ALS; motoneuron disease; neurodegeneration; neuroprotection; protein folding

Indexed keywords

BAG 1 PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; MALE; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGE FACTORS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MOTOR NEURONS; PHOSPHOPYRUVATE HYDRATASE; PROTO-ONCOGENE PROTEINS C-BCL-2; SPINAL CORD; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS; TRANSCRIPTION FACTORS;

EID: 56549103820     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.09.055     Document Type: Article

References (32)

1. Andersen P.M. Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene. Curr Neurol Neurosci Rep 6 (2006) 37-46
2. Boillee S., Yamanaka K., Lobsiger C.S., Copeland N.G., Jenkins N.A., Kassiotis G., Kollias G., and Cleveland D.W. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312 (2006) 1389-1392
3. Bruening W., Roy J., Giasson B., Figlewicz D.A., Mushynski W.E., and Durham H.D. Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis. J Neurochem 72 (1999) 693-699
4. Bruijn L.I., Becher M.W., Lee M.K., Anderson K.L., Jenkins N.A., Copeland N.G., Sisodia S.S., Rothstein J.D., Borchelt D.R., Price D.L., and Cleveland D.W. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 18 (1997) 327-338
5. Clement A.M., Nguyen M.D., Roberts E.A., Garcia M.L., Boillee S., Rule M., McMahon A.P., Doucette W., Siwek D., Ferrante R.J., Brown Jr. R.H., Julien J.P., Goldstein L.S., and Cleveland D.W. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302 (2003) 113-117
6. Frebel K., Wiese S., Funk N., Puhringer D., and Sendtner M. Differential modulation of neurite growth by the S- and the L-forms of bag1, a co-chaperone of Hsp70. Neurodegener Dis 4 (2007) 261-269
7. Friedlander R.M., Brown R.H., Gagliardini V., Wang J., and Yuan J. Inhibition of ICE slows ALS in mice. Nature 388 (1997) 31
8. Ganesan S., Rohde G., Eckermann K., Sroka K., Schaefer M.K., Dohm C.P., Kermer P., Haase G., Wouters F., Bähr M., and Weishaupt J.H. Mutant SOD1 detoxification mechanisms in intact single cells. Cell Death Differ 15 (2008) 312-321
9. Gotz R., Wiese S., Takayama S., Camarero G.C., Rossoll W., Schweizer U., Troppmair J., Jablonka S., Holtmann B., Reed J.C., Rapp U.R., and Sendtner M. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci 8 (2005) 1169-1178
10. Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H.X., et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264 (1994) 1772-1775
11. Heiman-Patterson T.D., Deitch J.S., Blankenhorn E.P., Erwin K.L., Perreault M.J., Alexander B.K., Byers N., Toman I., and Alexander G.M. Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS. J Neurol Sci 236 (2005) 1-7
12. Kermer P., Digicaylioglu M.H., Kaul M., Zapata J.M., Krajewska M., Stenner-Liewen F., Takayama S., Krajewski S., Lipton S.A., and Reed J.C. BAG1 over-expression in brain protects against stroke. Brain Pathol 13 (2003) 495-506
13. Kermer P., Krajewska M., Zapata J.M., Takayama S., Mai J., Krajewski S., and Reed J.C. Bag1 is a regulator and marker of neuronal differentiation. Cell Death Differ 9 (2002) 405-413
14. Kieran D., Kalmar B., Dick J.R., Riddoch-Contreras J., Burnstock G., and Greensmith L. Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice. Nat Med 10 (2004) 402-405
15. Kirby J., Menzies F.M., Cookson M.R., Bushby K., and Shaw P.J. Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease. Hum Mol Genet 11 (2002) 2061-2075
16. Kostic V., Jackson-Lewis V., de Bilbao F., Dubois-Dauphin M., and Przedborski S. Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 277 (1997) 559-562
17. Liman J., Ganesan S., Dohm C.P., Krajewski S., Reed J.C., Bähr M., Wouters F.S., and Kermer P. Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. Mol Cell Biol 25 (2005) 3715-3725
18. Liu J., Shinobu L.A., Ward C.M., Young D., and Cleveland D.W. Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis. J Neurochem 93 (2005) 875-882
19. Matsumoto G., Stojanovic A., Holmberg C.I., Kim S., and Morimoto R.I. Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates. J Cell Biol 171 (2005) 75-85
20. McClellan A.J., Tam S., Kaganovich D., and Frydman J. Protein quality control: chaperones culling corrupt conformations. Nat Cell Biol 7 (2005) 736-741
21. Patel Y.J., Payne Smith M.D., de Belleroche J., and Latchman D.S. Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells. Brain Res Mol Brain Res 134 (2005) 256-274
22. Pramatarova A., Laganiere J., Roussel J., Brisebois K., and Rouleau G.A. Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment. J Neurosci 21 (2001) 3369-3374
23. Rajdev S., Hara K., Kokubo Y., Mestril R., Dillmann W., Weinstein P.R., and Sharp F.R. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol 47 (2000) 782-791
24. Rowland L.P., and Shneider N.A. Amyotrophic lateral sclerosis. N Engl J Med 344 (2001) 1688-1700
25. Shinder G.A., Lacourse M.C., Minotti S., and Durham H.D. Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis. J Biol Chem 276 (2001) 12791-12796
26. Takayama S., Bimston D.N., Matsuzawa S., Freeman B.C., Aime-Sempe C., Xie Z., Morimoto R.I., and Reed J.C. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J 16 (1997) 4887-4896
27. Takayama S., Kochel K., Irie S., Inazawa J., Abe T., Sato T., Druck T., Huebner K., and Reed J.C. Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. Genomics 35 (1996) 494-498
28. Takeuchi H., Kobayashi Y., Yoshihara T., Niwa J., Doyu M., Ohtsuka K., and Sobue G. Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1. Brain Res 949 (2002) 11-22
29. Tummala H., Jung C., Tiwari A., Higgins C.M., Hayward L.J., and Xu Z. Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis. J Biol Chem 280 (2005) 17725-17731
30. Urushitani M., Kurisu J., Tateno M., Hatakeyama S., Nakayama K., Kato S., and Takahashi R. CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. J Neurochem 90 (2004) 231-244
31. Watanabe M., Dykes-Hoberg M., Culotta V.C., Price D.L., Wong P.C., and Rothstein J.D. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiol Dis 8 (2001) 933-941
32. Weishaupt J.H., Bartels C., Polking E., Dietrich J., Rohde G., Poeggeler B., Mertens N., Sperling S., Bohn M., Huther G., Schneider A., Bach A., Siren A.L., Hardeland R., Bähr M., Nave K.A., and Ehrenreich H. Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J Pineal Res 41 (2006) 313-323