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Volumn 7, Issue 22, 2008, Pages 3487-3490

Cdk5 and the non-catalytic arrest of the neuronal cell cycle

Author keywords

Cdk5; Cell cycle suppressor; E2F1; Non catalytic; p27

Indexed keywords

CYCLIN DEPENDENT KINASE 5;

EID: 56449083735     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.22.7045     Document Type: Review
Times cited : (39)

References (71)
  • 1
    • 0026452774 scopus 로고
    • Neuronal cdc2-like kinase: A cdc2-related protein kinase with predominantly neuronal expression
    • Hellmich MR, Pant HC, Wada E, Battey JF. Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. Proc Natl Acad Sci USA 1992; 89:10867-71.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10867-10871
    • Hellmich, M.R.1    Pant, H.C.2    Wada, E.3    Battey, J.F.4
  • 4
    • 0030962126 scopus 로고    scopus 로고
    • The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning
    • Philpott A, Porro EB, Kirschner MW, Tsai LH. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes Dev 1997; 11:1409-21.
    • (1997) Genes Dev , vol.11 , pp. 1409-1421
    • Philpott, A.1    Porro, E.B.2    Kirschner, M.W.3    Tsai, L.H.4
  • 5
    • 0030802113 scopus 로고    scopus 로고
    • Expression of Cdk5, p35 and Cdk5-associated kinase activity in the developing rat lens
    • Gao CY, Zakeri Z, Zhu Y, He H, Zelenka PS. Expression of Cdk5, p35 and Cdk5-associated kinase activity in the developing rat lens. Dev Genet 1997; 20:267-75.
    • (1997) Dev Genet , vol.20 , pp. 267-275
    • Gao, C.Y.1    Zakeri, Z.2    Zhu, Y.3    He, H.4    Zelenka, P.S.5
  • 8
    • 0027978170 scopus 로고
    • p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
    • Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 1994; 371:419-23.
    • (1994) Nature , vol.371 , pp. 419-423
    • Tsai, L.H.1    Delalle, I.2    Caviness Jr, V.S.3    Chae, T.4    Harlow, E.5
  • 9
    • 0033224309 scopus 로고    scopus 로고
    • The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases
    • Brown NR, Noble ME, Endicott JA, Johnson LN. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat Cell Biol 1999; 1:438-43.
    • (1999) Nat Cell Biol , vol.1 , pp. 438-443
    • Brown, N.R.1    Noble, M.E.2    Endicott, J.A.3    Johnson, L.N.4
  • 10
    • 0027165323 scopus 로고
    • Cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXKmotifs in neurofilament proteins: Isolation characterization
    • Shetty KT, Link WT, Pant HC. Cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXKmotifs in neurofilament proteins: isolation characterization. Proc Natl Acad Sci USA 1993; 90:6844-8.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6844-6848
    • Shetty, K.T.1    Link, W.T.2    Pant, H.C.3
  • 12
    • 0026459047 scopus 로고
    • D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
    • Xiong Y, Zhang H, Beach D. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 1992; 71:505-14.
    • (1992) Cell , vol.71 , pp. 505-514
    • Xiong, Y.1    Zhang, H.2    Beach, D.3
  • 13
    • 0031972946 scopus 로고    scopus 로고
    • Cyclin D2 interacts with Cdk5 and modulates cellular Cdk5/p35 activity
    • Guidato S, McLoughlin DM, Grierson AJ, Miller CC. Cyclin D2 interacts with Cdk5 and modulates cellular Cdk5/p35 activity. J neurochem 1998; 70:335-40.
    • (1998) J neurochem , vol.70 , pp. 335-340
    • Guidato, S.1    McLoughlin, D.M.2    Grierson, A.J.3    Miller, C.C.4
  • 14
    • 0027440552 scopus 로고
    • Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes
    • Zhang H, Xiong Y, Beach D. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell 1993; 4:897-906.
    • (1993) Mol Biol Cell , vol.4 , pp. 897-906
    • Zhang, H.1    Xiong, Y.2    Beach, D.3
  • 15
    • 0029066046 scopus 로고
    • Cyclin E is expressed in neurons and forms complexes with cdk5
    • Miyajima M, Nornes HO, Neuman T. Cyclin E is expressed in neurons and forms complexes with cdk5. Neuroreport 1995; 6:1130-2.
    • (1995) Neuroreport , vol.6 , pp. 1130-1132
    • Miyajima, M.1    Nornes, H.O.2    Neuman, T.3
  • 16
    • 0032529699 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex
    • Gilmore EC, Ohshima T, Goffinet AM, Kulkarni AB, Herrup K. Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J Neurosci 1998; 18:6370-7.
    • (1998) J Neurosci , vol.18 , pp. 6370-6377
    • Gilmore, E.C.1    Ohshima, T.2    Goffinet, A.M.3    Kulkarni, A.B.4    Herrup, K.5
  • 17
    • 0032403434 scopus 로고    scopus 로고
    • Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth
    • Paglini G, Pigino G, Kunda P, Morfini G, Maccioni R, Quiroga S, Ferreira A, Caceres A. Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth. J Neurosci 1998; 18:9858-69.
    • (1998) J Neurosci , vol.18 , pp. 9858-9869
    • Paglini, G.1    Pigino, G.2    Kunda, P.3    Morfini, G.4    Maccioni, R.5    Quiroga, S.6    Ferreira, A.7    Caceres, A.8
  • 18
    • 0348010575 scopus 로고    scopus 로고
    • Cdk5: A new player at synapses
    • Cheng K, Ip NY. Cdk5: a new player at synapses. Neurosignals 2003; 12:180-90.
    • (2003) Neurosignals , vol.12 , pp. 180-190
    • Cheng, K.1    Ip, N.Y.2
  • 21
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993; 262:2050-4.
    • (1993) Science , vol.262 , pp. 2050-2054
    • van den Heuvel, S.1    Harlow, E.2
  • 22
    • 0026557171 scopus 로고
    • Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice
    • al-Ubaidi MR, Hollyfield JG, Overbeek PA, Baehr W. Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. Proc Natl Acad Sci USA 1992; 89:1194-8.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1194-1198
    • al-Ubaidi, M.R.1    Hollyfield, J.G.2    Overbeek, P.A.3    Baehr, W.4
  • 23
    • 0026492630 scopus 로고
    • Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice
    • Feddersen RM, Ehlenfeldt R, Yunis WS, Clark HB, Orr HT. Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice. Neuron 1992; 9:955-66.
    • (1992) Neuron , vol.9 , pp. 955-966
    • Feddersen, R.M.1    Ehlenfeldt, R.2    Yunis, W.S.3    Clark, H.B.4    Orr, H.T.5
  • 24
    • 34247508686 scopus 로고    scopus 로고
    • Cell cycle regulation in the postmitotic neuron: Oxymoron or new biology?
    • Herrup K, Yang Y. Cell cycle regulation in the postmitotic neuron: oxymoron or new biology? Nat Rev Neurosci 2007; 8:368-78.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 368-378
    • Herrup, K.1    Yang, Y.2
  • 25
    • 0029078677 scopus 로고
    • The induction of multiple cell cycle events precedes target-related neuronal death
    • Herrup K, Busser JC. The induction of multiple cell cycle events precedes target-related neuronal death. Development 1995; 121:2385-95.
    • (1995) Development , vol.121 , pp. 2385-2395
    • Herrup, K.1    Busser, J.C.2
  • 26
    • 0030031514 scopus 로고    scopus 로고
    • Cyclin D1 is an essential mediator of apoptotic neuronal cell death
    • Kranenburg O, van der Eb AJ, Zantema A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J 1996; 15:46-54.
    • (1996) EMBO J , vol.15 , pp. 46-54
    • Kranenburg, O.1    van der Eb, A.J.2    Zantema, A.3
  • 27
    • 0029913242 scopus 로고    scopus 로고
    • Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons
    • Park DS, Farinelli SE, Greene LA. Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J Biol Chem 1996; 271:8161-9.
    • (1996) J Biol Chem , vol.271 , pp. 8161-8169
    • Park, D.S.1    Farinelli, S.E.2    Greene, L.A.3
  • 28
    • 0032529699 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex
    • Gilmore EC, Ohshima T, Goffinet AM, Kulkarni AB, Herrup K. Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J Neurosci 1998; 18:6370-7.
    • (1998) J Neurosci , vol.18 , pp. 6370-6377
    • Gilmore, E.C.1    Ohshima, T.2    Goffinet, A.M.3    Kulkarni, A.B.4    Herrup, K.5
  • 30
    • 27144478006 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
    • Cicero S, Herrup K. Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. J Neurosci 2005; 25:9658-68.
    • (2005) J Neurosci , vol.25 , pp. 9658-9668
    • Cicero, S.1    Herrup, K.2
  • 31
    • 0027425599 scopus 로고
    • Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system
    • Tsai LH, Takahashi T, Caviness VS Jr, Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 1993; 119:1029-40.
    • (1993) Development , vol.119 , pp. 1029-1040
    • Tsai, L.H.1    Takahashi, T.2    Caviness Jr, V.S.3    Harlow, E.4
  • 32
    • 0031569355 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling
    • Zhang Q, Ahuja HS, Zakeri ZF, Wolgemuth DJ. Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev Biol 1997; 83:222-33.
    • (1997) Dev Biol , vol.83 , pp. 222-233
    • Zhang, Q.1    Ahuja, H.S.2    Zakeri, Z.F.3    Wolgemuth, D.J.4
  • 33
    • 0032422684 scopus 로고    scopus 로고
    • Expression of cyclin-dependent kinase 5 and associated cyclins in Leydig and Sertoli cells of the testis
    • Musa FR, Tokuda M, Kuwata Y, Ogawa T, Tomizawa K, Konishi R, Takenaka I, Hatase O. Expression of cyclin-dependent kinase 5 and associated cyclins in Leydig and Sertoli cells of the testis. J Androl 1998; 19:657-66.
    • (1998) J Androl , vol.19 , pp. 657-666
    • Musa, F.R.1    Tokuda, M.2    Kuwata, Y.3    Ogawa, T.4    Tomizawa, K.5    Konishi, R.6    Takenaka, I.7    Hatase, O.8
  • 36
    • 36248982140 scopus 로고    scopus 로고
    • E2F1 works as a cell cycle suppressor in mature neurons
    • Wang L, Wang R, Herrup K. E2F1 works as a cell cycle suppressor in mature neurons. J Neurosci 2007; 27:12555-64.
    • (2007) J Neurosci , vol.27 , pp. 12555-12564
    • Wang, L.1    Wang, R.2    Herrup, K.3
  • 37
    • 32544459388 scopus 로고    scopus 로고
    • Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models
    • Yang Y, Varvel NH, Lamb BT, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models. J Neurosci 2006; 26:775-84.
    • (2006) J Neurosci , vol.26 , pp. 775-784
    • Yang, Y.1    Varvel, N.H.2    Lamb, B.T.3    Herrup, K.4
  • 39
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin dependent kinases
    • Sherr CJ, Roberts JM. Living with or without cyclins and cyclin dependent kinases. Genes Dev 2004; 18:2699-711.
    • (2004) Genes Dev , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 41
    • 0033634990 scopus 로고    scopus 로고
    • Cell cycle regulatory failure in neurons: Causes and consequences
    • Nagy Z. Cell cycle regulatory failure in neurons: causes and consequences. Neurobiol Aging 2000; 21:761-9.
    • (2000) Neurobiol Aging , vol.21 , pp. 761-769
    • Nagy, Z.1
  • 47
    • 0035803593 scopus 로고    scopus 로고
    • p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
    • Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J 2001; 20:6672-82.
    • (2001) EMBO J , vol.20 , pp. 6672-6682
    • Rodier, G.1    Montagnoli, A.2    Di Marcotullio, L.3    Coulombe, P.4    Draetta, G.F.5    Pagano, M.6    Meloche, S.7
  • 50
    • 30344479175 scopus 로고    scopus 로고
    • Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
    • Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 2006; 9:13-22.
    • (2006) Cancer Cell , vol.9 , pp. 13-22
    • Landis, M.W.1    Pawlyk, B.S.2    Li, T.3    Sicinski, P.4    Hinds, P.W.5
  • 53
    • 0034949169 scopus 로고    scopus 로고
    • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis
    • Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol 2001; 21:4684-99.
    • (2001) Mol Cell Biol , vol.21 , pp. 4684-4699
    • Ishida, S.1    Huang, E.2    Zuzan, H.3    Spang, R.4    Leone, G.5    West, M.6    Nevins, J.R.7
  • 56
    • 0344851640 scopus 로고    scopus 로고
    • Neuronal expression of cell cycle-related proteins after brain ischaemia in man
    • Love S. Neuronal expression of cell cycle-related proteins after brain ischaemia in man. Neurosci Lett 2003; 353:29-32.
    • (2003) Neurosci Lett , vol.353 , pp. 29-32
    • Love, S.1
  • 57
    • 12244303616 scopus 로고    scopus 로고
    • Cycling at the interface between neurodevelopment and neurodegeneration
    • Nguyen MD, Mushynski WE, Julien JP. Cycling at the interface between neurodevelopment and neurodegeneration. Cell Death Differ 2002; 9:1294-306.
    • (2002) Cell Death Differ , vol.9 , pp. 1294-1306
    • Nguyen, M.D.1    Mushynski, W.E.2    Julien, J.P.3
  • 58
    • 14944346310 scopus 로고    scopus 로고
    • Loss of neuronal cell cycle control in ataxia-telangiectasia: A unified disease mechanism
    • Yang Y, Herrup K. Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism. J Neurosci 2005; 25:2522-9.
    • (2005) J Neurosci , vol.25 , pp. 2522-2529
    • Yang, Y.1    Herrup, K.2
  • 59
    • 35648982325 scopus 로고    scopus 로고
    • Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury
    • Byrnes KR, Stoica BA, Fricke S, Giovanni SD, Faden AI. Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain 2007; 130:2977-92.
    • (2007) Brain , vol.130 , pp. 2977-2992
    • Byrnes, K.R.1    Stoica, B.A.2    Fricke, S.3    Giovanni, S.D.4    Faden, A.I.5
  • 61
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • Busser J, Geldmacher DS, Herrup K. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 1998; 18:2801-7.
    • (1998) J Neurosci , vol.18 , pp. 2801-2807
    • Busser, J.1    Geldmacher, D.S.2    Herrup, K.3
  • 63
    • 0035871660 scopus 로고    scopus 로고
    • DNA replication precedes neuronal cell death in Alzheimer's disease
    • Yang Y, Geldmacher DS, Herrup K. DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci 2001; 21:2661-8.
    • (2001) J Neurosci , vol.21 , pp. 2661-2668
    • Yang, Y.1    Geldmacher, D.S.2    Herrup, K.3
  • 64
    • 0344241479 scopus 로고    scopus 로고
    • Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    • Yang Y, Mufson EJ, Herrup K. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J Neurosci 2003; 23:2557-63.
    • (2003) J Neurosci , vol.23 , pp. 2557-2563
    • Yang, Y.1    Mufson, E.J.2    Herrup, K.3
  • 65
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators p16 and CDK4 in Alzheimer's disease
    • McShea A, Harris PL, Webster KR, Wahl AF, Smith MA. Abnormal expression of the cell cycle regulators p16 and CDK4 in Alzheimer's disease. Am J Pathol 1997; 150:1933-9.
    • (1997) Am J Pathol , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 66
    • 0033551712 scopus 로고    scopus 로고
    • Cell cycle-related protein expression in vascular dementia and Alzheimer's disease
    • Smith MZ, Nagy Z, Esiri MM. Cell cycle-related protein expression in vascular dementia and Alzheimer's disease. Neurosci Lett 1999; 271:45-8.
    • (1999) Neurosci Lett , vol.271 , pp. 45-48
    • Smith, M.Z.1    Nagy, Z.2    Esiri, M.M.3
  • 67
    • 0030454478 scopus 로고    scopus 로고
    • Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease
    • Arendt T, Rodel L, Gartner U, Holzer M. Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. Neuroreport 1996; 7:3047-9.
    • (1996) Neuroreport , vol.7 , pp. 3047-3049
    • Arendt, T.1    Rodel, L.2    Gartner, U.3    Holzer, M.4
  • 68
    • 0031737550 scopus 로고    scopus 로고
    • Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease
    • Arendt T, Holzer M, Gartner U. Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease. J Neural Transm 1998; 105:949-60.
    • (1998) J Neural Transm , vol.105 , pp. 949-960
    • Arendt, T.1    Holzer, M.2    Gartner, U.3
  • 71
    • 4444262625 scopus 로고    scopus 로고
    • Cdk5 deregulation in the pathogenesis of Alzheimer's disease
    • Cruz JC, Tsai LH. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med 2004; 10:452-8.
    • (2004) Trends Mol Med , vol.10 , pp. 452-458
    • Cruz, J.C.1    Tsai, L.H.2


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