Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity

Journal of Neurochemistry

Volumn 70, Issue 1, 1998, Pages 335-340

  Guidato, Sonia ^a   McLoughlin, Declan M ^a   Grierson, Andrew J ^a   Miller, Christopher C J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cyclin D2; Cyclin dependent kinase 5; Neurofilaments; P35; Tau

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NERVE FIBER GROWTH; NERVOUS SYSTEM; NERVOUS SYSTEM DEVELOPMENT; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MAMMALIA;

EID: 0031972946     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70010335.x     Document Type: Article

References (49)

1. Bajaj N. P. S. and Miller C. C. J. (1997) Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3a in transfected cells. J. Neurochem. 69, 737-743.
2. Baumann K., Mandelkow E.-M., Biernat J., Piwnica-Worms H., and Mandelkow E. (1993) Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin dependent kinases cdk2 and cdk5. FEBS Lett. 336, 417-424.
3. Bramblett G. T., Goedert M., Jakes R., Merrick S. E., Trojanowski J. Q., and Lee V. M.-Y. (1993) Abnormal tau phosphorylation at ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10, 1089-1099.
4. Brion J. P. and Couck A. M. (1995) Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5. Am. J. Pathol. 147, 1465-1476.
5. Brion J.-P., Smith C., Couck A.-M., Gallo J.-M., and Anderton B. H. (1993) Developmental changes in T phosphorylation: fetal τ is transiently phosphorylated in a manner similar to paired helical filament-τ characteristic of Alzheimer's disease. J. Neurochem. 61, 2071-2080.
6. Carden M. J., Trojanowski J. Q., Schlaepfer W. W., and Lee V. M.-Y. (1987) Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns. J. Neurosci. 7, 3489-3504.
7. Chin S. S. M. and Liem R. K. H. (1990) Transfected rat high-molecular-weight neurofilament (NF-H) coassembles with vimentin in a predominantly nonphosphorylated form. J. Neurosci. 10, 3714-3726.
8. Goedert M. (1993) Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci. 16, 460-465.
9. Goedert M., Jakes R., Crowther R. A., Six J., Lübke U., Vandermeeren M., Cras P., Trojanowski J. Q., and Lee V. M.-Y. (1993) The abnormal phosphorylation of tau protein at Ser202 in Alzheimer disease recapitulates phosphorylation during development. Proc. Nad. Acad. Sci. USA 90, 5066-5070.
10. Guidato S., Bajaj N. P. S., and Miller C. C. J. (1996a) Cellular phosphorylation of neurofilament heavy-chain by cyclin-dependent kinase-5 masks the epitope for monoclonal antibody N52. Neurosci. Lett. 217, 1-4.
11. Guidato S., Tsai L.-H., Woodgett J., and Miller C. C. J. (1996b) Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5. J. Neurochem. 66, 1698-1706.
12. Hata Y., Slaughter C. A., and Sudhof T. C. (1993) Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366, 347-351.
13. Hellmich M. R., Pant H. P., Wada E., and Battey J. F. (1992) Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. Proc. Natl. Acad. Sci. USA 89, 10867-10871.
14. Hirano A. (1991) Cytopathology of amyotrophic lateral sclerosis. Adv. Neurol. 56, 91-102.
15. Hisanaga S., Ishiguro K., Uchida T., Okumura E., Okano T., and Kishimoto T. (1993) Tau protein kinase II has a similar characteristic to cdc2 kinase for phosphorylating neurofilament proteins. J. Biol. Chem. 268, 15056-15060.
16. Hisanaga S., Uchiyama M., Hosoi T., Yamada K., Honma N., Ishiguro K., Uchida T., Dahl D., Ohsumi K., and Kishimoto T. (1995) Porcine brain neurofilament-H tail domain kinase: its identification as cdk5/p26 complex and comparison with cdc2/cyclin B kinase. Cell Motil. Cytoskel. 31, 283-297.
17. Ino H. and Chiba T. (1996) Intracellular localization of cyclin-dependent kinase 5 (CDK.5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm. Brain Res. 732, 179-185.
18. Ino H., Ishizuka T., Chiba T., and Tatibana M. (1994) Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems. Brain Res. 661, 196-206.
19. Ishiguro K., Kobayashi S., Omori A., Takamatsu M., Yonekura S., Anzai K., Imahori K., and Uchida T. (1994) Identification of the 23kDa subunit of tau protein kinase II as a putative activator of cdk-5 in bovine brain. FEBS Lett. 342, 203-208.
20. Lee K.-Y., Helbing C. C., Choi K.-S., Johnston R. N., and Wang J. H. (1997) Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein. J. Biol. Chem. 272, 5622-5626.
21. Kip1 in neurons. Proc. Natl. Acad. Sci. USA 93, 3259-3263.
22. Lee V. M. Y. (1995) Disruption of the cytoskeleton in Alzheimer's disease. Curr. Opin. Neurobiol. 5, 663-668.
23. Lees E. (1995) Cyclin dependent kinase regulation. Curr. Opin. Cell Biol. 7, 773-780.
24. Lew J. and Wang J. H. (1995) Neuronal cdc2-like kinase. Trends Biochem. Sci. 20, 33-37.
25. cdc2. J. Biol. Chem. 267, 25922-25926.
26. Lew J., Huang Q.-Q., Zhong Q., Winkfein R. J., Aebersold R., Hunt T., and Wang J. H. (1994) A brain-specific activator of cyclin-dependent kinase 5. Nature 371, 423-426.
27. Matsushita M., Matsui H., Itano T., Tomizawa K., Tokuda M., Suwaki H., Wang J. H., and Hatase O. (1995) Developmental changes of cyclin dependent kinase 5 subcellular localization in the rat cerebellum. Neuroreport 6, 1267-1270.
28. nck5a) in the developing rat cerebellum. Brain Res. 734, 319-322.
29. Mawal-Dewan M., Henley J., Van de Voorde A., Trojanowski J. Q., and Lee V. M.-Y. (1994) The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases. J. Biol. Chem. 269, 30981-30987.
30. Miyasaka H., Okabe S., Ishiguro K., Uchida T., and Hirokawa N. (1993) Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation by τ protein kinase II. J. Biol. Chem. 268, 22695-22702.
31. Nikolic M., Dudek H., Kwon Y. T., Ramos Y. F. M., and Tsai L. H. (1996) The cdk5/p35 kinase is essential for neunte outgrowth during neuronal differentiation. Genes Dev. 10, 816-825.
32. Nixon R. A., Paskevich P. A., Sihag R. K., and Thayer C. (1994) Phosphorylation on carboxy terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament spacing, and axon caliber. J. Cell Biol. 126, 1031-1046.
33. Ohshima T., Ward J. M., Huh C.-G., Longenecker G., Veeranna, Pant H. C., Brady R. O., Martin L. J., and Kulkarni A. B. (1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. USA 93, 11173-11178.
34. Paudel H. K., Lew J., Ali Z., and Wang J. H. (1993) Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments. J. Biol. Chem. 268, 23512-23518.
35. Pines J. (1995) Cyclins and cyclin-dependent kinases: a biochemical view. Biochem. J. 308, 697-711.
36. Pollanen M. S., Dickson D. W., and Bergeron C. (1993) Pathology and biology of the Lewy body. Neuropathol. Exp. Neurol. 52, 183-191.
37. Ross E. M. and Risken M. (1994) MN20, a D2 cyclin found in brain, is implicated in neural differentiation. J. Neurosci. 14, 6384-6391.
38. Sadowski I., Bell B., Broad P., and Hollis M. (1992) GAL4 fusion vectors for expression in yeast or mammalian cells. Gene 118, 137-141.
39. Sherr C. J. and Roberts J. M. (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163.
40. Shetty K. T., Link W. T., and Pant H. C. (1993) cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization. Proc. Natl. Acad. Sci. USA 90, 6844-6848.
41. Shetty K. T., Kaech S., Link W. T., Jaffe H., Flores C. M., Wray S., Pant H. C., and Beushausen S. (1995) Molecular characterization of a neuronal-specific protein that stimulates the activity of Cdk5. J. Neurochem. 64, 1988-1995.
42. Sun D., Leung C. L., and Liem R. K. H. (1996) Phosphorylation of the high molecular weight neurofilament protein (NF-H) by cdk-5 and p35. J. Biol. Chem. 271, 14245-14251.
43. Tamaru T., Okada M., and Nakagawa H. (1994) Differential expression of D type cyclins during neuronal maturation. Neurosci. Lett. 168, 229-232.
44. Tang D. M., Yeung J., Lee K. Y., Matsushita M., Matsui H., Tomizawa K., Hatase O., and Wang J. H. (1995) An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. J. Biol. Chem. 270, 26897-26903.
45. Trojanowski J. Q., Schmidt M. L., Shin R.-W., Bramblett G. T., Rao D., and Lee V. M.-Y. (1993) Altered tau and neurofilament proteins in neurodegenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias. Brain Pathol. 3, 45-54.
46. Tsai L.-H., Takahashi T., Caviness V. S. Jr., and Harlow E. (1993) Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 119, 1029-1040.
47. Tsai L.-H., Delalle I., Caviness V. S. Jr., Chae T., and Harlow E. (1994) p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371, 419-423.
48. Xiong Y., Zhang H., and Beach D. (1992) D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71, 505-514.
49. Xu Z., Cork L. C., Griffin J. W., and Cleveland D. W. (1993) Involvement of neurofilaments in motor neuron disease. J. Cell Sci. 106 (Suppl. 17), 101-108.