메뉴 건너뛰기




Volumn 292, Issue , 2008, Pages 68-78

Cytotoxic T cell mechanisms of β cell destruction in non-obese diabetic mice

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FAS ANTIGEN; PERFORIN;

EID: 56249097898     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper
Times cited : (6)

References (41)
  • 1
    • 0032506224 scopus 로고    scopus 로고
    • Mechanisms of beta cell death in diabetes: A minor role for CD95
    • Allison J, Strasser A 1998 Mechanisms of beta cell death in diabetes: a minor role for CD95. Proc Natl Acad Sci USA 95:13818-13822
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13818-13822
    • Allison, J.1    Strasser, A.2
  • 2
    • 21244498127 scopus 로고    scopus 로고
    • Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice
    • Allison J, Thomas HE Catterall T, Kay TW, Strasser A 2005 Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice. J Immunol 175:293-301
    • (2005) J Immunol , vol.175 , pp. 293-301
    • Allison, J.1    Thomas, H.E.2    Catterall, T.3    Kay, T.W.4    Strasser, A.5
  • 3
    • 0033560930 scopus 로고    scopus 로고
    • Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice
    • Amrani A, Verdaguer J, Anderson B, Utsugi T, Bou S, Santamaria P 1999 Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J Clin Invest 103:1201-1209
    • (1999) J Clin Invest , vol.103 , pp. 1201-1209
    • Amrani, A.1    Verdaguer, J.2    Anderson, B.3    Utsugi, T.4    Bou, S.5    Santamaria, P.6
  • 4
    • 0033621893 scopus 로고    scopus 로고
    • IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes
    • Amrani A, Verdaguer J, Thiessen S, Bou S, Santamaria P 2000 IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes. J Clin Invest 105:459-468
    • (2000) J Clin Invest , vol.105 , pp. 459-468
    • Amrani, A.1    Verdaguer, J.2    Thiessen, S.3    Bou, S.4    Santamaria, P.5
  • 5
    • 0141993915 scopus 로고    scopus 로고
    • Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes
    • Apostolou I, Hao Z, Rajewsky K, von Boehmer H 2003 Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med 198:1103-1106
    • (2003) J Exp Med , vol.198 , pp. 1103-1106
    • Apostolou, I.1    Hao, Z.2    Rajewsky, K.3    von Boehmer, H.4
  • 6
    • 28244436716 scopus 로고    scopus 로고
    • Effector function of diabetogenic CD4 Th1 T cell clones: A central role for TNF-alpha
    • Cantor J, Haskins K 2005 Effector function of diabetogenic CD4 Th1 T cell clones: a central role for TNF-alpha. J Immunol 175:7738-7745
    • (2005) J Immunol , vol.175 , pp. 7738-7745
    • Cantor, J.1    Haskins, K.2
  • 7
    • 4344680563 scopus 로고    scopus 로고
    • Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency
    • Chen Y, Chong MM, Darwiche R, Thomas HE, Kay TW 2004 Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency. Am J Pathol 165:913-921
    • (2004) Am J Pathol , vol.165 , pp. 913-921
    • Chen, Y.1    Chong, M.M.2    Darwiche, R.3    Thomas, H.E.4    Kay, T.W.5
  • 8
    • 0030890721 scopus 로고    scopus 로고
    • The role of Fas in autoimmune diabetes
    • Chervonsky AV, Wang Y, Wong FS et al 1997 The role of Fas in autoimmune diabetes. Cell 89:17-24
    • (1997) Cell , vol.89 , pp. 17-24
    • Chervonsky, A.V.1    Wang, Y.2    Wong, F.S.3
  • 9
    • 0037008769 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor
    • Chong MM, Thomas HE, Kay TW 2002 Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor. J Biol Chem 277:27945-27952
    • (2002) J Biol Chem , vol.277 , pp. 27945-27952
    • Chong, M.M.1    Thomas, H.E.2    Kay, T.W.3
  • 10
    • 0037396793 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation
    • Chong MM, Cornish AL, Darwiche R et al 2003 Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 18:475-487
    • (2003) Immunity , vol.18 , pp. 475-487
    • Chong, M.M.1    Cornish, A.L.2    Darwiche, R.3
  • 11
    • 2142761669 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction
    • Chong MM, Chen Y, Darwiche R et al 2004 Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction. J Immunol 172:5714-5721
    • (2004) J Immunol , vol.172 , pp. 5714-5721
    • Chong, M.M.1    Chen, Y.2    Darwiche, R.3
  • 12
    • 0027468997 scopus 로고
    • Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors
    • Christianson SW, Shultz LD, Leiter EH 1993 Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 42:44-55
    • (1993) Diabetes , vol.42 , pp. 44-55
    • Christianson, S.W.1    Shultz, L.D.2    Leiter, E.H.3
  • 13
    • 0037942773 scopus 로고    scopus 로고
    • Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice
    • Darwiche R, Chong MM, Santamaria P, Thomas HE, Kay TW 2003 Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice. J Immunol 170:6292-6297
    • (2003) J Immunol , vol.170 , pp. 6292-6297
    • Darwiche, R.1    Chong, M.M.2    Santamaria, P.3    Thomas, H.E.4    Kay, T.W.5
  • 14
    • 33750602224 scopus 로고    scopus 로고
    • Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways
    • Dudek NL, Thomas HE, Mariana L et al 2006 Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes 55:2412-2418
    • (2006) Diabetes , vol.55 , pp. 2412-2418
    • Dudek, N.L.1    Thomas, H.E.2    Mariana, L.3
  • 15
    • 33749370738 scopus 로고    scopus 로고
    • Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid
    • Estella E, McKenzie MD, Catterall T et al 2006 Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes 55:2212-2219
    • (2006) Diabetes , vol.55 , pp. 2212-2219
    • Estella, E.1    McKenzie, M.D.2    Catterall, T.3
  • 16
    • 0034176744 scopus 로고    scopus 로고
    • Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
    • Graser RT, DiLorenzo TP, Wang F et al 2000 Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164:3913-3918
    • (2000) J Immunol , vol.164 , pp. 3913-3918
    • Graser, R.T.1    DiLorenzo, T.P.2    Wang, F.3
  • 18
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
    • Hultgren B, Huang X, Dybdal N, Stewart TA 1996 Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes 45:812-817
    • (1996) Diabetes , vol.45 , pp. 812-817
    • Hultgren, B.1    Huang, X.2    Dybdal, N.3    Stewart, T.A.4
  • 19
    • 0036710448 scopus 로고    scopus 로고
    • Transmembrane TNF and IFNgamma induce caspase-independent death of primary mouse pancreatic beta cells
    • Irawaty W, Kay TW, Thomas HE 2002 Transmembrane TNF and IFNgamma induce caspase-independent death of primary mouse pancreatic beta cells. Autoimmunity 35:369-375
    • (2002) Autoimmunity , vol.35 , pp. 369-375
    • Irawaty, W.1    Kay, T.W.2    Thomas, H.E.3
  • 20
    • 1842289172 scopus 로고    scopus 로고
    • Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
    • Kagi D, Odermatt B, Seiler P, Zinkernagel RM, Mak TW, Hengartner H 1997 Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J Exp Med 186:989-997
    • (1997) J Exp Med , vol.186 , pp. 989-997
    • Kagi, D.1    Odermatt, B.2    Seiler, P.3    Zinkernagel, R.M.4    Mak, T.W.5    Hengartner, H.6
  • 21
    • 0034175965 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci
    • Kanagawa O, Xu G, Tevaarwerk A, Vaupel BA 2000 Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci. J Immunol 164: 3919-3923
    • (2000) J Immunol , vol.164 , pp. 3919-3923
    • Kanagawa, O.1    Xu, G.2    Tevaarwerk, A.3    Vaupel, B.A.4
  • 22
    • 0027367830 scopus 로고
    • Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
    • Katz J, Benoist C, Mathis D 1993 Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur J Immunol 23:3358-3360
    • (1993) Eur J Immunol , vol.23 , pp. 3358-3360
    • Katz, J.1    Benoist, C.2    Mathis, D.3
  • 23
    • 0030587871 scopus 로고    scopus 로고
    • RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null non-obese diabetic mice
    • Kay TW, Parker JL, Stephens LA, Thomas HE, Allison J 1996 RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null non-obese diabetic mice. J Immunol 157:3688-3693
    • (1996) J Immunol , vol.157 , pp. 3688-3693
    • Kay, T.W.1    Parker, J.L.2    Stephens, L.A.3    Thomas, H.E.4    Allison, J.5
  • 24
    • 25144464087 scopus 로고    scopus 로고
    • IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation
    • Kim HS, Kim S, Lee MS 2005 IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation. Biochem Biophys Res Commun 336:847-853
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 847-853
    • Kim, H.S.1    Kim, S.2    Lee, M.S.3
  • 25
    • 33846928411 scopus 로고    scopus 로고
    • NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice
    • Kim S, Millet I, Kim HS et al 2007 NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci USA 104:1913-1918
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1913-1918
    • Kim, S.1    Millet, I.2    Kim, H.S.3
  • 26
    • 0036207648 scopus 로고    scopus 로고
    • Mice with targeted gene disruptions or gene insertions for diabetes research: Problems, pitfalls, and potential solutions
    • Leiter EH 2002 Mice with targeted gene disruptions or gene insertions for diabetes research: problems, pitfalls, and potential solutions. Diabetologia 45:296-308
    • (2002) Diabetologia , vol.45 , pp. 296-308
    • Leiter, E.H.1
  • 27
    • 33750577982 scopus 로고    scopus 로고
    • Nuclear factor-kappaB regulates beta-cell death: A critical role for A20 in beta-cell protection
    • Liuwantara D, Elliot M, Smith MW et al 2006 Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection. Diabetes 55:2491-2501
    • (2006) Diabetes , vol.55 , pp. 2491-2501
    • Liuwantara, D.1    Elliot, M.2    Smith, M.W.3
  • 28
    • 0023905731 scopus 로고
    • Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice
    • Miller BJ, Appel MC, O'Neil JJ, Wicker LS 1988 Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol 140:52-58
    • (1988) J Immunol , vol.140 , pp. 52-58
    • Miller, B.J.1    Appel, M.C.2    O'Neil, J.J.3    Wicker, L.S.4
  • 29
    • 33744921639 scopus 로고    scopus 로고
    • IL-1 beta breaks tolerance through expansion of CD25+ effector T cells
    • O'Sullivan BJ, Thomas HE, Pai S et al 2006 IL-1 beta breaks tolerance through expansion of CD25+ effector T cells. J Immunol 176:7278-7287
    • (2006) J Immunol , vol.176 , pp. 7278-7287
    • O'Sullivan, B.J.1    Thomas, H.E.2    Pai, S.3
  • 30
    • 0030920680 scopus 로고    scopus 로고
    • IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice
    • Sandberg JO, Eizirik DL, Sandler S 1997 IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice. Clin Exp Immunol 108:314-317
    • (1997) Clin Exp Immunol , vol.108 , pp. 314-317
    • Sandberg, J.O.1    Eizirik, D.L.2    Sandler, S.3
  • 31
    • 0023841728 scopus 로고
    • Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma
    • Sarvetnick N, Liggitt D, Pitts SL, Hansen SE, Stewart TA 1988 Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52:773-782
    • (1988) Cell , vol.52 , pp. 773-782
    • Sarvetnick, N.1    Liggitt, D.2    Pitts, S.L.3    Hansen, S.E.4    Stewart, T.A.5
  • 33
    • 0027979956 scopus 로고
    • Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant
    • Serreze DV, Leiter EH, Christianson GJ, Greiner D, Roopenian DC 1994 Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes 43:505-509
    • (1994) Diabetes , vol.43 , pp. 505-509
    • Serreze, D.V.1    Leiter, E.H.2    Christianson, G.J.3    Greiner, D.4    Roopenian, D.C.5
  • 34
    • 0033669375 scopus 로고    scopus 로고
    • Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice
    • Serreze DV, Post CM, Chapman HD, Johnson EA, Lu B, Rothman PB 2000 Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. Diabetes 49:2007-2011
    • (2000) Diabetes , vol.49 , pp. 2007-2011
    • Serreze, D.V.1    Post, C.M.2    Chapman, H.D.3    Johnson, E.A.4    Lu, B.5    Rothman, P.B.6
  • 35
    • 0032531099 scopus 로고    scopus 로고
    • IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes
    • Thomas HE, Parker JL, Schreiber RD, Kay TW 1998 IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes. J Clin Invest 102:1249-1257
    • (1998) J Clin Invest , vol.102 , pp. 1249-1257
    • Thomas, H.E.1    Parker, J.L.2    Schreiber, R.D.3    Kay, T.W.4
  • 36
    • 0347360367 scopus 로고    scopus 로고
    • IL-1 receptor deficiency slows progression to diabetes in the NOD mouse
    • Thomas HE, Irawaty W, Darwiche R et al 2004 IL-1 receptor deficiency slows progression to diabetes in the NOD mouse. Diabetes 53:113-121
    • (2004) Diabetes , vol.53 , pp. 113-121
    • Thomas, H.E.1    Irawaty, W.2    Darwiche, R.3
  • 37
    • 33645092675 scopus 로고    scopus 로고
    • Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death
    • Thomas HE, Angstetra E, Fernandes RV et al 2006 Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death. Immunol Cell Biol 84:20-27
    • (2006) Immunol Cell Biol , vol.84 , pp. 20-27
    • Thomas, H.E.1    Angstetra, E.2    Fernandes, R.V.3
  • 38
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • Trapani JA, Smyth MJ 2002 Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2:735-747
    • (2002) Nat Rev Immunol , vol.2 , pp. 735-747
    • Trapani, J.A.1    Smyth, M.J.2
  • 40
    • 0028006398 scopus 로고
    • Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes
    • Wicker LS, Leiter EH, Todd JA et al 1994 Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43:500-504
    • (1994) Diabetes , vol.43 , pp. 500-504
    • Wicker, L.S.1    Leiter, E.H.2    Todd, J.A.3
  • 41
    • 13344294394 scopus 로고    scopus 로고
    • CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells
    • Wong FS, Visintin I, Wen L, Flavell RA, Janeway CA Jr 1996 CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med 183:67-76
    • (1996) J Exp Med , vol.183 , pp. 67-76
    • Wong, F.S.1    Visintin, I.2    Wen, L.3    Flavell, R.A.4    Janeway Jr, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.