Mice with targeted gene disruptions or gene insertions for diabetes research: Problems, pitfalls, and potential solutions

Diabetologia

Volumn 45, Issue 3, 2002, Pages 296-308

  Leiter, E H ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

Gene targeting; Genetics; Mice; Mutations; Transgenics

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; GENE DISRUPTION; GENE EXPRESSION; GENE INSERTION; GENE MUTATION; GENE TARGETING; GENETIC LINKAGE; GENETIC MANIPULATION; GENETIC RECOMBINATION; GENETIC SUSCEPTIBILITY; GENOME; GLUCOSE HOMEOSTASIS; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MEDICAL RESEARCH; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE; TRANSGENICS;

ANIMALS; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GLUCOSE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC;

EID: 0036207648     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-001-0743-z     Document Type: Review

References (78)

1. A miracle enough: The power of mice
2. Genetically engineered mice. Husbandry and resources
3. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice
4. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice
5. Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain
6. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
7. Establishment of a germline competent C57BL/6 embryonic stem cell line
8. A novel ES cell line, TT2, with high germline-differentiating potency
9. Establishment of an embryonic stem (ES) cell line derived from a non- obese diabetic (NOD) mouse: In vivo differentiation into lymphocytes and potential for germ line transmission
10. Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
11. Single nutrients and immunity
12. Non-insulin dependent diabetes genes in mice: Deleterious synergism by both parental genomes contributes to diabetogenic thresholds
13. Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci
14. Crosses of NOD mice with the related NON strain: A polygenic model for type I diabetes
15. Genetic control of autoimmune diabetes in the NOD mouse
16. Occurrence of pretype I diabetes (pre-IDDM) and type II diabetes (NIDDM) in BC1 [(NOD x Mus spretus)F1 x NOD] mice
17. 3J, a new mutation at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization
18. Genetic analysis of obesity-induced diabetes associated with a limited capacity to synthesize insulin in C57BL/Ks mice: Evidence for polygenic control
19. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
20. Genetic modifiers of the insulin resistance phenotype in mice
21. The polygenetics of diabesity in mice
22. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
23. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
24. Studies on experimental diabetes in the Wellesley hybrid mouse. II. Serum insulin levels and response of peripheral tissues
25. Interaction between BTBR and C57BL/6 J genomes produces an insulin resistance syndrome in (BTBR x C57BL/6 J) F1 mice
26. Control of spontaneous glucose intolerance, hyperinsulinemia, and islet hyperplasia in nonobese C3H.SW male mice by Y-linked locus and adrenal gland
27. Congenic strains reveal effects of the epilepsy quantitative trait locus, E12, separate from other El loci
28. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes
29. null mice are diabetes and insulitis resistant
30. β2 microglobulin-deficient NOD mice do not develop insulitis or diabetes
31. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
32. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4
33. CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP-ribose
34. The CD38-cyclic ADP-ribose signaling system in insulin secretion
35. CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2 + ]i, and insulin secretion
36. The NSY mouse: A new animal model of spontaneous NIDDM with moderate obesity
37. NIDDM in a new mouse model elicited by low free radical scavenging potential combined with behaviorial and dietary stress
38. Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice
39. The NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM 12 and NRAMP1 loci in humans
40. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
41. Th1 to Th2 cytokine shifts in nonobese diabetic mice: Sometimes an outcome rather than the cause of diabetes resistance elicited by immunostimulation
42. Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes
43. Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci
44. Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice
45. Heritable susceptibility to colitis in mice induced by interleukin-10 deficiency
46. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
47. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
48. Poly(ADP-ribose) polymerase-1: What have we learned from the deficient mouse model?
49. Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase
50. Insulin receptor substrate 3 is not essential for growth or glucose homeostasis
51. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia
52. The role of environmental factors in modulating insulin dependent diabetes
53. NOD mice and related strains: Origins, husbandry, and biology
54. The NOD mouse model of type 1 diabetes: As good as it gets?
55. Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4
56. Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus
57. Prosomatostatin processing in permeabilized cells. Endoproteolytic cleavage is mediated by a vacuolar ATPase that generates an acidic pH in the trans-Golgi network
58. A gene-targeting approach identifies a function for the first intron in expression of the alphal(I) collagen gene
59. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency
60. Immune responses in interleukin-2-deficient mice
61. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
62. Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome
63. Major histocompatibility complex molecules and the beta-cell: Inferences from transgenic mice
64. Quantitative thresholds of MHC Class II I-E expression on hematopoietically derived APC in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection
65. Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta cells
66. The NOD mouse: A model for insulin dependent diabetes mellitus
67. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells
68. GABA(A) receptors mediate inhibition of T cell responses
69. Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens: Nonimmunized nonobese diabetic mice can develop autoimmune encephalitis
70. Development of spontaneous autoimmune peripheral polyneuropathy in B7-2- deficient NOD mice
71. null mice
72. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
73. A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes
74. Targeted expression of Cre recombinase to myelinating cells of the central nervous system in transgenic mice
75. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
76. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
77. Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1