Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1

Journal of Medicinal Chemistry

Volumn 51, Issue 21, 2008, Pages 6689-6698

  Desbouis, Dominique ^a,b   Struthers, Harriet ^a,b   Spiwok, Vojtech ^c   Küster, Tatjana ^b   Schibli, Roger ^a,b  

^a ETH ZURICH   (Switzerland)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

RHENIUM; TECHNETIUM; THYMIDINE KINASE 1;

ARTICLE; COMPUTER MODEL; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NEUROBLASTOMA CELL; PROTEIN PHOSPHORYLATION; SYNTHESIS;

CELL LINE, TUMOR; CHELATING AGENTS; COMPUTATIONAL BIOLOGY; ENZYME ACTIVATION; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOTECHNETIUM COMPOUNDS; PHOSPHORYLATION; RHENIUM; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE;

EID: 56249096578     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800530p     Document Type: Article

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