Influence of the denticity of ligand systems on the in vitro and in vivo behavior of 99mTc(I)-tricarbonyl complexes: A hint for the future functionalization of biomolecules

Bioconjugate Chemistry

Volumn 11, Issue 3, 2000, Pages 345-351

  Schibli, Roger ^a   La Bella, Roberto ^a   Alberto, Roger ^b   Garcia Garayoa, Elisa ^a   Ortner, Kirstin ^b   Abram, Ulrich ^c   Schubiger, P A ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; BODY FLUIDS; LIGANDS; MOLECULES; ORGANOMETALLICS; PROTEINS;

BIDENTATE LIGANDS; COMPLEX 1; CONDITION; COORDINATED LIGANDS; FUNCTIONALIZATIONS; IN-VITRO; LABELINGS; LIGAND SYSTEM; NO DECOMPOSITION; PLASMA SAMPLES;

AMINO ACIDS;

ANIMALIA; MURINAE;

EID: 0034030754     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc990127h     Document Type: Article

References (20)

1. Johannsen, B., and Spiess, H. (1996) Technetium(V) Chemistry as Relevant to Nuclear Medicine. In Technetium and Rhenium (Yoshihara, K., and Omori, T., Eds.) Vol. 176, pp 77-122, Springer-Verlag, Berlin, Heidelberg, New York.
2. Lister-James, J., Moyen, B. R., and Dean, T. (1996) Small peptides radiolabeled with 99mTc. Q. J. Nucl. Med. 40, 221-233.
3. 2DADS. J. Nucl. Med. 24, 353-355.
4. Decristoforo, C., and Mather, S. J. (1999) 99m-technetium-labeled peptide-HYNIC conjugates: Effects of lipophilicity and stability on biodistribution. J. Nucl. Biol. Med. 26, 389-396.
5. Edwards, D. S., and Liu, S. (1997) Tc-99m-labeling of hydrazinonicotinamide (HYNIC) modified highly potent small molecules: problems and solutions. Transition Met. Chem. 22, 425-426.
6. Salmain, M., Gunn, M., Gorfi, A., Top, S., and Jaouen, G. (1993) Labeling of Proteins by Organometallic Complexes of Rhenium(I). Synthesis and Biological Activity of the Conjugates. Bioconjugate Chem. 4, 425-433.
7. Top, S., Hafa, E. H., Vessières, A., Quivy, J., Vaissermann, J., Hughes, D. W., McGlinchey, M. J., Mornon, J.-P., Thoreau, E., and Jaouen, G. (1995) Rhenium Carbonyl Complexes of β-Estradiol Derivatives with High Affinity for the Estradiol Receptor: An Approach to Selective Organometallic Radiopharmaceuticals. J. Am. Chem. Soc. 117, 8372-8380.
8. 99mTc-Aquaion labels peptide to unprecedented High specific activity. J. Nucl. Med., 40, 1913-1917.
9. 1A Receptor Ligand Labeled with 99mTc. J. Am. Chem. Soc., 121, 6076-6077.
10. Spradau, T. W., Edwards, W. B., Anderson, C. J., Welch, M. J., and Katzenellenbogen, J. A. (1999) Synthesis and Biological Evaluation of Tc-99m-Cyclopentadienyltricarbonyl-technetium-Labeled Octreotide. Nucl. Med. Biol. 26, 1-7.
11. Wenzel, M., and Saidi, M. (1993) Esters of Tc-99m labeled cytectrencarboxylic acid with alcohols of cyclic amines as cerebral radiodiagnostic agents. J. Labelled Compd. Radiopharm. 33, 77-80.
12. 4] in Aqueous Solution and its Reaction with Bifunctional Ligands. J. Am. Chem. Soc. 120, 7987-7988.
13. 6]. Polyhedron 15, 1079-1089.
14. 2. Inorg. Chem. 37, 3509-3516.
15. 6. Inorg. Chem. 37, 5306-5312.
16. 3]. Transition Met. Chem. 22, 597-601.
17. 3]Br. Inorg. Chim. Acta (in preparation)
18. 99mTc with a Multidentate Amine Oxime. Int. J. Appl. Radiat, Isot. 35, 467-470.
19. 99mTc-Oxo Complexes of L, L-EC and L,L-EDC. In Technetium and Rhenium in Chemistry and Nuclear Medicine (Nicolini, M., Bandoli, G., and Mazzi, U., Eds.) Vol. 4, pp 405-407, SGE, Verona.
20. 2 Complexes. In Technetium and Rhenium in Chemistry and Nuclear Medicine (Nicolini, M., Bandoli, G., and Mazzi, U., Eds.) Vol. 4, pp 329-332, SGE, Verona.