Synthesis and evaluation of a 99mTc-MAMA-propyl-thymidine complex as a potential probe for in vivo visualization of tumor cell proliferation with SPECT

Nuclear Medicine and Biology

Volumn 34, Issue 3, 2007, Pages 283-291

  Celen, Sofie ^a   de Groot, Tjibbe ^b   Balzarini, Jan ^c   Vunckx, Kathleen ^b   Terwinghe, Christelle ^b   Vermaelen, Peter ^b   Van Berckelaer, Lizette ^c   Vanbilloen, Hubert ^b   Nuyts, Johan ^b   Mortelmans, Luc ^b   Verbruggen, Alfons ^a   Bormans, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Radio LC MS; RIF tumor; Technetium 99m; Thymidine; TK1

Indexed keywords

3' DEOXY 3' FLUOROTHYMIDINE F 18; 3' FLUOROTHYMIDINE; MONOAMINO MONOAMIDE DITHIOL PROPYLTHYMIDINE TC 99M; RADIOPHARMACEUTICAL AGENT; THIOL; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; ELECTROPHORESIS; FIBROSARCOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGING; IN VIVO STUDY; INTESTINE; LABELING INDEX; LIQUID CHROMATOGRAPHY; LIVER; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PLASMA CLEARANCE; PROTON NUCLEAR MAGNETIC RESONANCE; RADIATION INJURY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION; TUMOR CELL;

ANIMALS; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; FEASIBILITY STUDIES; FIBROSARCOMA; METABOLIC CLEARANCE RATE; MICE; MICE, NUDE; MOLECULAR PROBE TECHNIQUES; NEOPLASM STAGING; ORGAN SPECIFICITY; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 33947315626     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2007.01.003     Document Type: Article

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