Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression

Journal of Medicinal Chemistry

Volumn 49, Issue 17, 2006, Pages 5377-5381

  Pillarsetty, Nagavarakishore ^a   Cai, Shangde ^a   Ageyeva, Lyudmila ^a   Finn, Ronald D ^a   Blasberg, Ronald G ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BROMO 2 DEOXY 2 FLUOROSUGAR DERIVATIVE; 2' FLUORO 2' DEOXY 5 BROMOVINYL 1 BETA DEXTRO ARABINOFURANOSYLURACIL; 2' FLUORO 2' DEOXY 5 PROPYL 1 BETA DEXTRO ARABINOFURANOSYLURACIL; 2' FLUORO 2' DEOXY 5 TRIFLUOROMETHYL 1 BETA DEXTRO ARABINOFURANOSYLURACIL; FLUORINE 18; FLUORO 1 BETA DEXTRO ARABINOFURANOSYLURACIL DERIVATIVE; PYRIMIDINE NUCLEOSIDE; THYMIDINE KINASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; FLUORINE;

ANIMAL CELL; ARTICLE; CELL LINE; CHEMICAL STRUCTURE; ENERGY; GENE EXPRESSION; GLIOMA CELL; HERPES SIMPLEX VIRUS 1; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HSV1 TK GENE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS; VIRUS GENE; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IN VITRO STUDY; METHODOLOGY; STEREOISOMERISM; TIME; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; FLUORINE RADIOISOTOPES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HERPESVIRUS 1, HUMAN; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINE NUCLEOSIDES; RATS; STEREOISOMERISM; THYMIDINE KINASE; TIME FACTORS;

EID: 33747472945     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0512847     Document Type: Article

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