Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERα) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice

Toxicology and Applied Pharmacology

Volumn 233, Issue 2, 2008, Pages 193-202

  Lee, Junga ^a   Scheri, Richard C ^a   Zhang, Yuan ^b   Curtis, Lawrence R ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apolipoproteins; Chlordecone; Cholesterol; Estrogen receptor ; Liver X receptors; Organochlorine insecticides; Pregnane X receptor

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B100; APOLIPOPROTEIN B48; CARBON 14; CHLORDECONE; CHOLESTEROL; CHOLESTEROL ESTER; CYTOCHROME P450 3A11; ESTROGEN RECEPTOR ALPHA; FARNESOID X RECEPTOR; LIPOPROTEIN; ORGANOCHLORINE INSECTICIDE; PREGNANE X RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CHOLESTEROL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; HUMAN CELL; LIPOPROTEIN METABOLISM; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; RECEPTOR UPREGULATION; REPORTER GENE;

ANIMALS; APOLIPOPROTEIN A-I; APOLIPOPROTEIN B-100; APOLIPOPROTEIN B-48; CELL LINE; CHLORDECONE; CHOLESTEROL; CYTOCHROME P-450 CYP3A; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN RECEPTOR ALPHA; GENES, REPORTER; HOMEOSTASIS; HUMANS; INSECTICIDES; LIPOPROTEINS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS;

MUS; RATTUS; RODENTIA;

EID: 56049100467     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.08.011     Document Type: Article

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