Assessment of interactions of diverse ternary mixtures in an estrogen receptor-α reporter assay

Toxicology and Applied Pharmacology

Volumn 180, Issue 1, 2002, Pages 11-21

  Charles, Grantley D ^a   Gennings, C ^b   Zacharewski, Timothy R ^c   Gollapudi, B Bhaskar ^a   Carney, Edward W ^a  

^a DOW CHEMICAL COMPANY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c Michigan State University   (United States)

Author keywords

Additivity; Endocrine; Estrogen receptor; Mixture; Pesticide; Polyaromatic hydrocarbon; Response surface; Synergy

Indexed keywords

1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; BENZO[A]PYRENE; BENZ[A]ANTHRACENE; CHRYSENE; DIELDRIN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; GENISTEIN; METHOXYCHLOR; PESTICIDE; PHYTOESTROGEN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ARTICLE; CELL STRAIN MCF 7; CHEMICAL INTERACTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; REPORTER GENE;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0036535268     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9346     Document Type: Article

References (45)

1. Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides
2. In vitro synergistic interaction of alligator and human estrogen receptors with combinations of environmental chemicals
3. Carcinogenic polycyclic aromatic hydrocarbons
4. The expected effect of a combination of agents: The general solution
5. The estrogen receptor relative binding affinities of 188 natural and xenochemicals: Structural diversity of ligands
6. A case of a laboratory animal feed with high estrogenic activity and its impact on in vivo responses to exogenously administered estrogens
7. Rapid screening of environmental chemicals for estrogen receptor binding capacity
8. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenases in methoxychlor activation
9. Activity of benzo(a)pyrene and its hydroxylated metabolites in an ER-α reporter gene assay
10. Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators
11. 10 air particulate material using in vitro gene expression assays
12. Toxicity studies in rats of simple mixtures of chemicals with the same or different target organs
13. An efficient experimental design for detecting departure from additivity in mixtures of many chemicals
14. Analysis of a mixture of estrogen agonists in an ER-α reporter gene assay
15. Subacute toxicity of a mixture of nine chemicals in rats: Detecting interactive effects with a fractionated two-level factorial design
16. Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium
17. Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays
18. Synergisms with mixtures of xenoestrogens: A reevaluation using the method of isoboles
19. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β
20. Estrogenic activity assessment of environmental chemicals using in vitro assays: Identification of two new estrogenic compounds
21. The problem of synergism and antagonism of combined drugs
22. Uber kombinationswirkunger. I. Mitteilung: Hiltsmittel der fragstellung
23. The development of mothods for assessing the in vitro oestrogen-like effects of xenobiotics in CD-1 mice
24. Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay
25. Lung tumorigenic interactions in strain A/J mice of five environmental polycyclic aromatic hydrocarbons
26. Estrogenic activities of methoxychlor metabolites
27. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: No apparent synergism
28. Binary effects of carcinogens and tumor promoters: A preliminary structural analysis of BCIDB and PCIDB
29. Environmental estrogens induce transcriptionally active estrogen receptor dimers in yeast: Activity potentiated by the coactivator RIP140
30. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays
31. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells
32. Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYPIA2 in O-demethylation
33. Six high-priority organochlorine pesticides, either singly or in combination, are nonestrogenic in transfected HeLa cells
34. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
35. A proposed approach to study the toxicology of complex mixtures of petroleum products: The integrated use of QSAR, lumping analysis and PBPK/PD modeling
36. Interactions between endosulfan and dieldrin on estrogen-mediated processes in vitro and in vivo
37. A potent specific pure antiestrogen with clinical potential
38. Molecular effects of genistein on estrogen receptor mediated pathways
39. Estrogenic action of DDT and its analogs
40. Polynuclear aromatic hydrocarbons, steroids and carcinogenesis
41. In vitro bioassays for assessing estrogenic substances
42. Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17β-estradiol-induced pS2 expression
43. Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture