-
1
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
2
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, et al. (1999) Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96: 701-712.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
-
3
-
-
0034769105
-
Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres
-
Samper E, Flores JM, Blasco MA (2001) Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres. EMBO Rep 2: 800-807.
-
(2001)
EMBO Rep
, vol.2
, pp. 800-807
-
-
Samper, E.1
Flores, J.M.2
Blasco, M.A.3
-
4
-
-
19844382620
-
Senescence and immortalization: Role of telomeres and telomerase
-
Shay JW, Wright WE (2005) Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 26: 867-874.
-
(2005)
Carcinogenesis
, vol.26
, pp. 867-874
-
-
Shay, J.W.1
Wright, W.E.2
-
5
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
-
Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-513.
-
(2004)
Mol Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, B.P.3
Chen, D.J.4
Sedivy, J.M.5
-
6
-
-
0036677405
-
MEC3, MEC1, and DDC2 Are Essential Components of a Telomere Checkpoint Pathway Required for Cell Cycle Arrest during Senescence in Saccharomyces cerevisiae
-
Enomoto S, Glowczewski L, Berman J (2002) MEC3, MEC1, and DDC2 Are Essential Components of a Telomere Checkpoint Pathway Required for Cell Cycle Arrest during Senescence in Saccharomyces cerevisiae. Mol Biol Cell 13: 2626-2638.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 2626-2638
-
-
Enomoto, S.1
Glowczewski, L.2
Berman, J.3
-
7
-
-
0025787643
-
Telomere loss: Mitotic clock or genetic time bomb?
-
Harley CB (1991) Telomere loss: mitotic clock or genetic time bomb? Mut.Res. 256: 271-282.
-
(1991)
Mut.Res
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
8
-
-
0026523228
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
-
Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, et al. (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11: 1921-1929.
-
(1992)
EMBO J
, vol.11
, pp. 1921-1929
-
-
Counter, C.M.1
Avilion, A.A.2
LeFeuvre, C.E.3
Stewart, N.G.4
Greider, C.W.5
-
9
-
-
0031000884
-
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
-
Makarov VL, Hirose Y, Langmore JP (1997) Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88: 657-666.
-
(1997)
Cell
, vol.88
, pp. 657-666
-
-
Makarov, V.L.1
Hirose, Y.2
Langmore, J.P.3
-
10
-
-
0030731928
-
Normal human chromosomes have long G-rich telomeric overhangs at one end
-
Wright WE, Tesmer VM, Huffman KE, Levene SD, Shay JW (1997) Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11: 2801-2809.
-
(1997)
Genes Dev
, vol.11
, pp. 2801-2809
-
-
Wright, W.E.1
Tesmer, V.M.2
Huffman, K.E.3
Levene, S.D.4
Shay, J.W.5
-
11
-
-
0030982721
-
The terminal DNA structure of mammalian chromosomes
-
McElligott R, Wellinger RJ (1997) The terminal DNA structure of mammalian chromosomes. EMBO J. 16: 3705-3714.
-
(1997)
EMBO J
, vol.16
, pp. 3705-3714
-
-
McElligott, R.1
Wellinger, R.J.2
-
12
-
-
0033605145
-
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
de Lange, T.5
-
13
-
-
34548317418
-
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
-
Denchi EL, de Lange T (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448: 1068-1071.
-
(2007)
Nature
, vol.448
, pp. 1068-1071
-
-
Denchi, E.L.1
de Lange, T.2
-
14
-
-
36248952723
-
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
-
Guo X, Deng Y, Lin Y, Cosme-Blanco W, Chan S, et al. (2007) Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. Embo J 26: 4709-4719.
-
(2007)
Embo J
, vol.26
, pp. 4709-4719
-
-
Guo, X.1
Deng, Y.2
Lin, Y.3
Cosme-Blanco, W.4
Chan, S.5
-
15
-
-
0030447657
-
The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA binding protein in vitro that affects telomere behavior in vivo
-
Lin JJ, Zakian VA (1996) The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA binding protein in vitro that affects telomere behavior in vivo. Proc.Natl.Acad.Sci.USA 93: 13760-13765.
-
(1996)
Proc.Natl.Acad.Sci.USA
, vol.93
, pp. 13760-13765
-
-
Lin, J.J.1
Zakian, V.A.2
-
16
-
-
0029845892
-
Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
-
Nugent CI, Hughes TR, Lue NF, Lundblad V (1996) Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274: 249-252.
-
(1996)
Science
, vol.274
, pp. 249-252
-
-
Nugent, C.I.1
Hughes, T.R.2
Lue, N.F.3
Lundblad, V.4
-
17
-
-
0028822203
-
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
-
Garvik B, Carson M, Hartwell L (1995) Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol.Cell Biol. 15: 6128-6138.
-
(1995)
Mol.Cell Biol
, vol.15
, pp. 6128-6138
-
-
Garvik, B.1
Carson, M.2
Hartwell, L.3
-
18
-
-
0030460748
-
Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase
-
Dionne I, Wellinger RJ (1996) Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase. Proc.Natl.Acad.Sci.USA 93: 13902-13907.
-
(1996)
Proc.Natl.Acad.Sci.USA
, vol.93
, pp. 13902-13907
-
-
Dionne, I.1
Wellinger, R.J.2
-
19
-
-
0037047643
-
Est1p as a cell cycle-regulated activator of telomere-bound telomerase
-
Taggart AK, Teng SC, Zakian VA (2002) Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science 297: 1023-1026.
-
(2002)
Science
, vol.297
, pp. 1023-1026
-
-
Taggart, A.K.1
Teng, S.C.2
Zakian, V.A.3
-
20
-
-
0038012805
-
Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast
-
Qi H, Li TK, Kuo D, Nur-E-Kamal, Liu LF (2003) Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast. J Biol Chem 278: 15136-15141.
-
(2003)
J Biol Chem
, vol.278
, pp. 15136-15141
-
-
Qi, H.1
Li, T.K.2
Kuo, D.3
Liu, N.-E.L.F.4
-
21
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
22
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, et al. (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-890.
-
(2004)
Curr Biol
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
-
23
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K, Chen D, Riddle DL (2004) The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131: 3897-3906.
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
24
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, et al. (2003) Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426: 620.
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
-
25
-
-
27744511769
-
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
-
Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, et al. (2005) Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients. Science 310: 1193-1196.
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers 3rd, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
-
26
-
-
0028561918
-
Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue
-
Stan R, McLaughlin MM, Cafferkey R, Johnson RK, Rosenberg M, et al. (1994) Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. J Biol Chem 269: 32027-32030.
-
(1994)
J Biol Chem
, vol.269
, pp. 32027-32030
-
-
Stan, R.1
McLaughlin, M.M.2
Cafferkey, R.3
Johnson, R.K.4
Rosenberg, M.5
-
27
-
-
0026775898
-
Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex
-
Aldape RA, Futer O, DeCenzo MT, Jarrett BP, Murcko MA, et al. (1992) Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex. J Biol Chem 267: 16029-16032.
-
(1992)
J Biol Chem
, vol.267
, pp. 16029-16032
-
-
Aldape, R.A.1
Futer, O.2
DeCenzo, M.T.3
Jarrett, B.P.4
Murcko, M.A.5
-
28
-
-
0036899644
-
Elucidating TOR signaling and rapamycin action: Lessons from Saccharomyces cerevisiae
-
table of contents
-
Crespo JL, Hall MN (2002) Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev 66: 579-591, table of contents.
-
(2002)
Microbiol Mol Biol Rev
, vol.66
, pp. 579-591
-
-
Crespo, J.L.1
Hall, M.N.2
-
29
-
-
0032485937
-
Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
-
Hashemolhosseini S, Nagamine Y, Morley SJ, Desrivieres S, Mercep L, et al. (1998) Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J Biol Chem 273: 14424-14429.
-
(1998)
J Biol Chem
, vol.273
, pp. 14424-14429
-
-
Hashemolhosseini, S.1
Nagamine, Y.2
Morley, S.J.3
Desrivieres, S.4
Mercep, L.5
-
30
-
-
18844415826
-
The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain
-
Barberis M, De Gioia L, Ruzzene M, Sarno S, Coccetti P, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387: 639-647.
-
(2005)
Biochem J
, vol.387
, pp. 639-647
-
-
Barberis, M.1
De Gioia, L.2
Ruzzene, M.3
Sarno, S.4
Coccetti, P.5
-
31
-
-
33846964530
-
Rapamycin-mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae
-
Zinzalla V, Graziola M, Mastriani A, Vanoni M, Alberghina L (2007) Rapamycin-mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae. Mol Microbiol 63: 1482-1494.
-
(2007)
Mol Microbiol
, vol.63
, pp. 1482-1494
-
-
Zinzalla, V.1
Graziola, M.2
Mastriani, A.3
Vanoni, M.4
Alberghina, L.5
-
32
-
-
0025900189
-
Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
-
Aparicio OM, Billington BL, Gottschling DE (1991) Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell 66: 1279-1287.
-
(1991)
Cell
, vol.66
, pp. 1279-1287
-
-
Aparicio, O.M.1
Billington, B.L.2
Gottschling, D.E.3
-
33
-
-
0033781559
-
Telomere folding is required for the stable maintenance of telomere position effects in yeast
-
de Bruin D, Kantrow SM, Liberatore RA, Zakian VA (2000) Telomere folding is required for the stable maintenance of telomere position effects in yeast. Mol.Cell.Biol. 20: 7991-8000.
-
(2000)
Mol.Cell.Biol
, vol.20
, pp. 7991-8000
-
-
de Bruin, D.1
Kantrow, S.M.2
Liberatore, R.A.3
Zakian, V.A.4
-
34
-
-
0027184524
-
Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage
-
Renauld H, Aparicio OM, Zierath PD, Billington BL, Chhablani SK, et al. (1993) Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes and Development 7: 1133-1145.
-
(1993)
Genes and Development
, vol.7
, pp. 1133-1145
-
-
Renauld, H.1
Aparicio, O.M.2
Zierath, P.D.3
Billington, B.L.4
Chhablani, S.K.5
-
35
-
-
34250811414
-
The Role of Autophagy in Mitochondria Maintenance: Characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains
-
Zhang Y, Qi H, Taylor R, Xu W, Liu LF, et al. (2007) The Role of Autophagy in Mitochondria Maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains. Autophagy 3: 337-346.
-
(2007)
Autophagy
, vol.3
, pp. 337-346
-
-
Zhang, Y.1
Qi, H.2
Taylor, R.3
Xu, W.4
Liu, L.F.5
-
36
-
-
4644273585
-
Uth1p is involved in the autophagic degradation of mitochondria
-
Kissova I, Deffieu M, Manon S, Camougrand N (2004) Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 279: 39068-39074.
-
(2004)
J Biol Chem
, vol.279
, pp. 39068-39074
-
-
Kissova, I.1
Deffieu, M.2
Manon, S.3
Camougrand, N.4
-
37
-
-
0032575551
-
Apg14p and Apg6/ Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae
-
Kametaka S, Okano T, Ohsumi M, Ohsumi Y (1998) Apg14p and Apg6/ Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem 273: 22284-22291.
-
(1998)
J Biol Chem
, vol.273
, pp. 22284-22291
-
-
Kametaka, S.1
Okano, T.2
Ohsumi, M.3
Ohsumi, Y.4
-
38
-
-
0034661246
-
The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase- associated est1 protein
-
Qi H, Zakian VA (2000) The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase- associated est1 protein. Genes Dev. 14: 1777-1788.
-
(2000)
Genes Dev
, vol.14
, pp. 1777-1788
-
-
Qi, H.1
Zakian, V.A.2
-
39
-
-
0024973811
-
A mutant with a defect in telomere elongation leads to senescence in yeast
-
Lundblad V, Szostak JW (1989) A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57: 633-643.
-
(1989)
Cell
, vol.57
, pp. 633-643
-
-
Lundblad, V.1
Szostak, J.W.2
-
40
-
-
0033513079
-
Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
-
Teng S-C, Zakian VA (1999) Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol.Cell.Biol. 19: 8083-8093.
-
(1999)
Mol.Cell.Biol
, vol.19
, pp. 8083-8093
-
-
Teng, S.-C.1
Zakian, V.A.2
-
41
-
-
33845995861
-
A protease pathway for the repair of topoisomerase II-DNA covalent complexes
-
Zhang A, Lyu YL, Lin CP, Zhou N, Azarova AM, et al. (2006) A protease pathway for the repair of topoisomerase II-DNA covalent complexes. J Biol Chem 281: 35997-36003.
-
(2006)
J Biol Chem
, vol.281
, pp. 35997-36003
-
-
Zhang, A.1
Lyu, Y.L.2
Lin, C.P.3
Zhou, N.4
Azarova, A.M.5
-
42
-
-
0033540030
-
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
-
Beck T, Hall MN (1999) The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402: 689-692.
-
(1999)
Nature
, vol.402
, pp. 689-692
-
-
Beck, T.1
Hall, M.N.2
-
43
-
-
33748752151
-
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
-
Schieke SM, Phillips D, McCoy JP Jr, Aponte AM, Shen RF, et al. (2006) The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem 281: 27643-27652.
-
(2006)
J Biol Chem
, vol.281
, pp. 27643-27652
-
-
Schieke, S.M.1
Phillips, D.2
McCoy Jr, J.P.3
Aponte, A.M.4
Shen, R.F.5
-
44
-
-
10744230830
-
Chronological aging leads to apoptosis in yeast
-
Herker E, Jungwirth H, Lehmann KA, Maldener C, Frohlich KU, et al. (2004) Chronological aging leads to apoptosis in yeast. J Cell Biol 164: 501-507.
-
(2004)
J Cell Biol
, vol.164
, pp. 501-507
-
-
Herker, E.1
Jungwirth, H.2
Lehmann, K.A.3
Maldener, C.4
Frohlich, K.U.5
-
45
-
-
30944458446
-
Extension of chronological life span in yeast by decreased TOR pathway signaling
-
Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20: 174-184.
-
(2006)
Genes Dev
, vol.20
, pp. 174-184
-
-
Powers 3rd, R.W.1
Kaeberlein, M.2
Caldwell, S.D.3
Kennedy, B.K.4
Fields, S.5
-
46
-
-
33947574775
-
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression
-
Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS (2007) Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab 5: 265-277.
-
(2007)
Cell Metab
, vol.5
, pp. 265-277
-
-
Bonawitz, N.D.1
Chatenay-Lapointe, M.2
Pan, Y.3
Shadel, G.S.4
-
47
-
-
0028841139
-
Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae
-
Schneider BL, Seufert W, Steiner B, Yang QH, Futcher AB (1995) Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae. Yeast 11: 1265-1274.
-
(1995)
Yeast
, vol.11
, pp. 1265-1274
-
-
Schneider, B.L.1
Seufert, W.2
Steiner, B.3
Yang, Q.H.4
Futcher, A.B.5
|