-
1
-
-
9244221172
-
Tissue repair and stem cell renewal in carcinogenesis
-
Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432:324-31.
-
(2004)
Nature
, vol.432
, pp. 324-331
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
2
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-71.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
-
3
-
-
0025856717
-
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991;66:649-61.
-
(1991)
Cell
, vol.66
, pp. 649-661
-
-
Ellisen, L.W.1
Bird, J.2
West, D.C.3
-
4
-
-
0034674896
-
Chromosome 19 translocation, overexpression of Notch3, and human lung cancer
-
Dang TP, Gazdar AF, Virmani AK, et al. Chromosome 19 translocation, overexpression of Notch3, and human lung cancer. J Natl Cancer Inst 2000;92:1355-7.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1355-1357
-
-
Dang, T.P.1
Gazdar, A.F.2
Virmani, A.K.3
-
5
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
Wood LD, Parsons DW, Jones S, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007;318:1108-13.
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
-
7
-
-
20844455582
-
Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays
-
Matsuzaki H, Dong S, Loi H, et al. Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat Methods 2004;1:109-11.
-
(2004)
Nat Methods
, vol.1
, pp. 109-111
-
-
Matsuzaki, H.1
Dong, S.2
Loi, H.3
-
8
-
-
33745685874
-
Notch-3 gene amplification in ovarian cancer
-
Park JT, Li M, Nakayama N, et al. Notch-3 gene amplification in ovarian cancer. Cancer Res 2006;66:6312-8.
-
(2006)
Cancer Res
, vol.66
, pp. 6312-6318
-
-
Park, J.T.1
Li, M.2
Nakayama, N.3
-
9
-
-
33746546368
-
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
-
Weng AP, Millholland JM, Yashiro-Ohtani Y, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev 2006;20:2096-109.
-
(2006)
Genes Dev
, vol.20
, pp. 2096-2109
-
-
Weng, A.P.1
Millholland, J.M.2
Yashiro-Ohtani, Y.3
-
10
-
-
33645751939
-
Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis
-
Talora C, Cialfi S, Oliviero C, et al. Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis. Blood 2006;107:3313-20.
-
(2006)
Blood
, vol.107
, pp. 3313-3320
-
-
Talora, C.1
Cialfi, S.2
Oliviero, C.3
-
11
-
-
0029085935
-
Signalling downstream of activated mammalian Notch
-
Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature 1995;377:355-8.
-
(1995)
Nature
, vol.377
, pp. 355-358
-
-
Jarriault, S.1
Brou, C.2
Logeat, F.3
Schroeter, E.H.4
Kopan, R.5
Israel, A.6
-
12
-
-
0034902568
-
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): Implication for cell cycle disruption in transformation by Notch(ic)
-
Ronchini C, Capobianco AJ. Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol 2001;21:5925-34.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5925-5934
-
-
Ronchini, C.1
Capobianco, A.J.2
-
13
-
-
0041672357
-
Identifying tumor origin using a gene expression-based classification map
-
Buckhaults P, Zhang Z, Chen YC, et al. Identifying tumor origin using a gene expression-based classification map. Cancer Res 2003;63:4144-9.
-
(2003)
Cancer Res
, vol.63
, pp. 4144-4149
-
-
Buckhaults, P.1
Zhang, Z.2
Chen, Y.C.3
-
14
-
-
33745839365
-
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
-
Wysocka J, Swigut T, Xiao H, et al. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 2006;442:86-90.
-
(2006)
Nature
, vol.442
, pp. 86-90
-
-
Wysocka, J.1
Swigut, T.2
Xiao, H.3
-
15
-
-
0033036185
-
Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
-
Jacobs Y, Schnabel CA, Cleary ML. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol 1999;19:5134-42.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5134-5142
-
-
Jacobs, Y.1
Schnabel, C.A.2
Cleary, M.L.3
-
16
-
-
30944467528
-
Notch3 signaling initiates choroid plexus tumor formation
-
Dang L, Fan X, Chaudhry A, Wang M, Gaiano N, Eberhart CG. Notch3 signaling initiates choroid plexus tumor formation. Oncogene 2006;25:487-91.
-
(2006)
Oncogene
, vol.25
, pp. 487-491
-
-
Dang, L.1
Fan, X.2
Chaudhry, A.3
Wang, M.4
Gaiano, N.5
Eberhart, C.G.6
-
17
-
-
33846303880
-
Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression
-
Shiraishi K, Yamasaki K, Nanba D, et al. Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression. Oncogene 2007;26:339-48.
-
(2007)
Oncogene
, vol.26
, pp. 339-348
-
-
Shiraishi, K.1
Yamasaki, K.2
Nanba, D.3
-
18
-
-
0036023971
-
A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
-
Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C. A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep 2002;3:688-94.
-
(2002)
EMBO Rep
, vol.3
, pp. 688-694
-
-
Geling, A.1
Steiner, H.2
Willem, M.3
Bally-Cuif, L.4
Haass, C.5
-
19
-
-
33947214529
-
Notch signaling, γ-secretase inhibitors, and cancer therapy
-
Shih IM, Wang TL. Notch signaling, γ-secretase inhibitors, and cancer therapy. Cancer Res 2007;67:1879-82.
-
(2007)
Cancer Res
, vol.67
, pp. 1879-1882
-
-
Shih, I.M.1
Wang, T.L.2
-
20
-
-
0025064238
-
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
-
Nourse J, Mellentin JD, Galili N, et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 1990;60:535-45.
-
(1990)
Cell
, vol.60
, pp. 535-545
-
-
Nourse, J.1
Mellentin, J.D.2
Galili, N.3
-
21
-
-
0025137176
-
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
-
Kamps MP, Murre C, Sun XH, Baltimore D. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 1990;60:547-55.
-
(1990)
Cell
, vol.60
, pp. 547-555
-
-
Kamps, M.P.1
Murre, C.2
Sun, X.H.3
Baltimore, D.4
-
22
-
-
22144492615
-
Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21
-
Minter LM, Turley DM, Das P, et al. Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol 2005;6:680-8.
-
(2005)
Nat Immunol
, vol.6
, pp. 680-688
-
-
Minter, L.M.1
Turley, D.M.2
Das, P.3
-
23
-
-
34547780475
-
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
-
O'Neil J, Grim J, Strack P, et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors. J Exp Med 2007;204:1813-24.
-
(2007)
J Exp Med
, vol.204
, pp. 1813-1824
-
-
O'Neil, J.1
Grim, J.2
Strack, P.3
-
24
-
-
33847083871
-
Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling
-
Lewis HD, Leveridge M, Strack PR, et al. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol 2007;14:209-19.
-
(2007)
Chem Biol
, vol.14
, pp. 209-219
-
-
Lewis, H.D.1
Leveridge, M.2
Strack, P.R.3
-
25
-
-
48649090161
-
Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion
-
Choi JH, Park JT, Davidson B, Morin PJ, Shih IM, Wang TL. Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. Cancer Res 2008;68:5716-23.
-
(2008)
Cancer Res
, vol.68
, pp. 5716-5723
-
-
Choi, J.H.1
Park, J.T.2
Davidson, B.3
Morin, P.J.4
Shih, I.M.5
Wang, T.L.6
-
26
-
-
0028641294
-
Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision
-
Wilkinson HA, Fitzgerald K, Greenwald I. Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell 1994;79:1187-98.
-
(1994)
Cell
, vol.79
, pp. 1187-1198
-
-
Wilkinson, H.A.1
Fitzgerald, K.2
Greenwald, I.3
-
27
-
-
0037090983
-
Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm
-
Carmena A, Buff E, Halfon MS, et al. Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev Biol 2002;244:226-42.
-
(2002)
Dev Biol
, vol.244
, pp. 226-242
-
-
Carmena, A.1
Buff, E.2
Halfon, M.S.3
-
28
-
-
0030297895
-
An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
-
Robey E, Chang D, Itano A, et al. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 1996;87:483-92.
-
(1996)
Cell
, vol.87
, pp. 483-492
-
-
Robey, E.1
Chang, D.2
Itano, A.3
-
29
-
-
0029898760
-
Extra specificity from extra-denticle: The partnership between HOX and PBX/EXD homeodomain proteins
-
Mann RS, Chan S-K. Extra specificity from extra-denticle: the partnership between HOX and PBX/EXD homeodomain proteins. Trends Genet 1996;12:258.
-
(1996)
Trends Genet
, vol.12
, pp. 258
-
-
Mann, R.S.1
Chan, S.-K.2
-
30
-
-
2442575665
-
Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential
-
Berkes CA, Bergstrom DA, Penn BH, Seaver KJ, Knoepfler PS, Tapscott SJ. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol Cell 2004;14:465.
-
(2004)
Mol Cell
, vol.14
, pp. 465
-
-
Berkes, C.A.1
Bergstrom, D.A.2
Penn, B.H.3
Seaver, K.J.4
Knoepfler, P.S.5
Tapscott, S.J.6
-
31
-
-
0034798317
-
Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation
-
Selleri L, Depew MJ, Jacobs Y, et al. Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development 2001;128:3543-57.
-
(2001)
Development
, vol.128
, pp. 3543-3557
-
-
Selleri, L.1
Depew, M.J.2
Jacobs, Y.3
-
32
-
-
0035437164
-
The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver
-
DiMartino JF, Selleri L, Traver D, et al. The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. Blood 2001;98:618-26.
-
(2001)
Blood
, vol.98
, pp. 618-626
-
-
DiMartino, J.F.1
Selleri, L.2
Traver, D.3
-
33
-
-
0036544854
-
Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
-
Kim SK, Selleri L, Lee JS, et al. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat Genet 2002;30:430.
-
(2002)
Nat Genet
, vol.30
, pp. 430
-
-
Kim, S.K.1
Selleri, L.2
Lee, J.S.3
-
34
-
-
0037442838
-
Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney
-
Schnabel CA, Godin RE, Cleary ML. Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney. Dev Biol 2003;254:262.
-
(2003)
Dev Biol
, vol.254
, pp. 262
-
-
Schnabel, C.A.1
Godin, R.E.2
Cleary, M.L.3
-
35
-
-
34248362004
-
B-cell development fails in the absence of the Pbx1 protooncogene
-
Sanyal M, Tung JW, Karsunky H, et al. B-cell development fails in the absence of the Pbx1 protooncogene. Blood 2007;109:4191-9.
-
(2007)
Blood
, vol.109
, pp. 4191-4199
-
-
Sanyal, M.1
Tung, J.W.2
Karsunky, H.3
-
36
-
-
0026033596
-
The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials
-
Kamps MP, Look AT, Baltimore D. The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev 1991;5:358-68.
-
(1991)
Genes Dev
, vol.5
, pp. 358-368
-
-
Kamps, M.P.1
Look, A.T.2
Baltimore, D.3
-
37
-
-
0042161874
-
Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior
-
LaRonde-LeBlanc NA, Wolberger C. Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev 2003;17:2060-72.
-
(2003)
Genes Dev
, vol.17
, pp. 2060-2072
-
-
LaRonde-LeBlanc, N.A.1
Wolberger, C.2
-
38
-
-
0034598793
-
HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis
-
Schnabel CA, Jacobs Y, Cleary ML. HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis. Oncogene 2000;19:608-16.
-
(2000)
Oncogene
, vol.19
, pp. 608-616
-
-
Schnabel, C.A.1
Jacobs, Y.2
Cleary, M.L.3
-
39
-
-
36248937213
-
Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis
-
Argiropoulos B, Yung E, Humphries RK. Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis. Genes Dev 2007;21:2845-9.
-
(2007)
Genes Dev
, vol.21
, pp. 2845-2849
-
-
Argiropoulos, B.1
Yung, E.2
Humphries, R.K.3
-
40
-
-
35948964020
-
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
-
Wong P, Iwasaki M, Somervaille TC, So CW, Cleary ML. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev 2007;21:2762-74.
-
(2007)
Genes Dev
, vol.21
, pp. 2762-2774
-
-
Wong, P.1
Iwasaki, M.2
Somervaille, T.C.3
So, C.W.4
Cleary, M.L.5
-
41
-
-
0035909949
-
Aberrant expression of homeobox gene HOXA7 is associated with mullerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response
-
Naora H, Montz FJ, Chai CY, Roden RB. Aberrant expression of homeobox gene HOXA7 is associated with mullerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response. Proc Natl Acad Sci U S A 2001;98:15209-14.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 15209-15214
-
-
Naora, H.1
Montz, F.J.2
Chai, C.Y.3
Roden, R.B.4
-
42
-
-
18344373769
-
Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
-
Cheng W, Liu J, Yoshida H, Rosen D, Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med 2005;11:531-7.
-
(2005)
Nat Med
, vol.11
, pp. 531-537
-
-
Cheng, W.1
Liu, J.2
Yoshida, H.3
Rosen, D.4
Naora, H.5
-
44
-
-
20544460148
-
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es JH, van Gijn ME, Riccio O, et al. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005;435:959-63.
-
(2005)
Nature
, vol.435
, pp. 959-963
-
-
van Es, J.H.1
van Gijn, M.E.2
Riccio, O.3
|