The novel isoflavone 7-hydroxy-3′,4′-benzoisoflavone induces cell apoptosis in human osteosarcoma cells

Cancer Letters

Volumn 271, Issue 1, 2008, Pages 117-128

  Hou, Chun Han ^a,b   Fong, Yi Chin ^c,d   Chen, Jung Tsan ^d   Liu, Ju Fang ^d   Lin, Min Sheng ^d   Chang, Chih Shiang ^d   Tang, Chih Hsin ^d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

ASK1; Isoflavone; JNK; Osteosarcoma; P38

Indexed keywords

7 HYDROXY 3',4' BENZOISOFLAVONE; ALPHA TUBULIN; APOPTOSIS SIGNAL REGULATING KINASE 1; CATALASE; CYTOCHROME C; ISOFLAVONE DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; CELL LINE, TUMOR; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; ISOFLAVONES; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 5; OSTEOSARCOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 54849185600     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.05.037     Document Type: Article

References (37)

1. Ek E.T., and Choong P.F. The role of high-dose therapy and autologous stem cell transplantation for pediatric bone and soft tissue sarcomas. Expert Rev. Anticancer Ther. 6 (2006) 225-237
2. Feig D.I., Reid T.M., and Loeb L.A. Reactive oxygen species in tumorigenesis. Cancer Res. 54 (1994) 1890-1894
3. Schumacker P.T. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10 (2006) 175-176
4. Moungjaroen J., Nimmannit U., Callery P.S., Wang L., Azad N., Lipipun V., Chanvorachote P., and Rojanasakul Y. Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J. Pharmacol. Exp. Ther. 319 (2006) 1062-1069
5. 2+ mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells. J. Pharmacol. Exp. Ther. 319 (2006) 1276-1285
6. Kim B.C., Kim H.G., Lee S.A., Lim S., Park E.H., Kim S.J., and Lim C.J. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem. Pharmacol. 70 (2005) 1398-1407
7. Ling Y.H., Liebes L., Zou Y., Perez-Soler R., generation R.o.s., Bortezomib m.d.i.t.a.r.t., and inhibitor a.n.p. in human H460 non-small cell lung cancer cells. J. Biol. Chem. 278 (2003) 33714-33723
8. Imoto K., Kukidome D., Nishikawa T., Matsuhisa T., Sonoda K., Fujisawa K., Yano M., Motoshima H., Taguchi T., Tsuruzoe K., Matsumura T., Ichijo H., and Araki E. Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling. Diabetes 55 (2006) 1197-1204
9. Hsieh C.C., and Papaconstantinou J. Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. FASEB J. 20 (2006) 259-268
10. Nishitoh H., Matsuzawa A., Tobiume K., Saegusa K., Takeda K., Inoue K., Hori S., Kakizuka A., and Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16 (2002) 1345-1355
11. Tobiume K., Matsuzawa A., Takahashi T., Nishitoh H., Morita K., Takeda T., Minowa Q., Miyazono K., Noda T., and Ichijo H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2 (2001) 222-228
12. Ouyang M., and Shen X. Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. J. Neurochem. 97 (2006) 234-244
13. Hwang J.R., Zhang C., and Patterson C. C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis. Cell Stress Chaperones 10 (2005) 147-156
14. Matsuzawa A., Nishitoh H., Tobiume K., Takeda K., and Ichijo H. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Antioxid. Redox. Signal. 4 (2002) 415-425
15. Goldman E.H., Chen L., and Fu H. Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation. J. Biol. Chem. 279 (2004) 10442-10449
16. Liu H., Zhang H., Iles K.E., Rinna A., Merrill G., Yodoi J., Torres M., and Forman H.J. The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Free Radic. Res. 40 (2006) 865-874
17. Song J.J., and Lee Y.J. Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1. Biochem. J. 373 (2003) 845-853
18. Liu H., Nishitoh H., Ichijo H., and Kyriakis J.M. Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol. Cell Biol. 20 (2000) 2198-2208
19. Saitoh M., Nishitoh H., Fujii M., Takeda K., Tobiume K., Sawada Y., Kawabata M., Miyazono K., and Ichijo H. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 17 (1998) 2596-2606
20. Su J.L., Lin M.T., Hong C.C., Chang C.C., Shiah S.G., Wu C.W., Chen S.T., Chau Y.P., and Kuo M.L. Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells. Carcinogenesis 26 (2005) 1-10
21. Saeki K., Kobayashi N., Inazawa Y., Zhang H., Nishitoh H., Ichijo H., Saeki K., Isemura M., and You A. Oxidation triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukemia cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. Biochem. J. 368 (2002) 705-720
22. Sarkar F.H., and Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev. 21 (2002) 265-280
23. Formica J.V., and Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol. 33 (1995) 1061-1080
24. Limer J.L., and Speirs V. Phyto-oestrogens and breast cancer chemoprevention. Breast Cancer Res. 6 (2004) 119-127
25. Fong Y.C., Yang W.H., Hsu S.F., Hsu H.C., Tseng K.F., Hsu C.J., Lee C.Y., and Scully S.P. 2-methoxyestradiol induces apoptosis and cell cycle arrest in human chondrosarcoma cells. J. Orthop. Res. 25 (2007) 1106-1114
26. Zhang Y., and Chen F. Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK). Cancer Res. 64 (2004) 1902-1905
27. Zhang L., Chen J., and Fu H. Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc. Natl. Acad. Sci. USA 96 (1996) 8511-8515
28. Ichijo H., Nishida E., Irie K., ten Dijke P., Saitoh M., Moriguchi T., Takagi M., Matsumoto K., Miyazono K., Gotoh Y., and ASK1 I.o.a.b. a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275 (1997) 90-94
29. Dumaz N., and Meek D.W. Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J. 18 (1999) 7002-7010
30. Meek D.W. Mechanisms of switching on p53: a role for covalent modification?. Oncogene 18 (1999) 7666-7675
31. Jeffers J.R., Parganas E., Lee Y., Yang C., Wang J., Brennan J., MacLean K.H., Han J., Chittenden T., Ihle J.N., McKinnon P.J., Cleveland J.L., and Zambetti G.P. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4 (2003) 321-328
32. Hastak K., Agarwal M.K., Mukhtar H., and Agarwal M.L. Ablation of either p21 or Bax prevents p53-dependent apoptosis-induced by green tea polyphenol epigallocatechin-3-gallate. FASEB J. 19 (2005) 789-791
33. Valko M., Rhodes C.J., Moncol J., Izakovic M., and Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 160 (2006) 1-40
34. Holasek S.S., Wengenack T.M., Kandimalla K.K., Montano C., Gregor D.M., Curran G.L., and Poduslo J.F. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Brain Res. 1045 (2005) 185-198
35. el-Deiry W.S., Tokino T., Waldman T., Oliner J.D., Velculescu V.E., Burrell M., Hill D.E., Healy E., Rees J.L., Hamilton S.R., Kinzler K.W., and Vogelstein B. Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 55 (1995) 2910-2919
36. Lagranha C.J., Hirabara S.M., Curi R., and Pithon-Curi T.C. Glutamine supplementation prevents exercise-induced neutrophil apoptosis and reduces p38 MAPK and JNK phosphorylation and p53 and caspase 3 expression. Cell Biochem. Funct. 25 (2007) 563-569
37. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776