The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801

Neuropharmacology

Volumn 40, Issue 6, 2001, Pages 749-760

  Rammes, G ^a   Mahal, B ^a   Putzke, J ^b   Parsons, C ^c   Spielmanns, P ^c   Pestel, E ^a   Spanagel, R ^a   Zieglgansberger W ^a   Schadrack, J ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

Acamprosate; Alcohol; Anti craving compounds; Ethanol; Memantine; MK 801; NMDA receptor; Protein expression; Splice variants; Subunits

Indexed keywords

ACAMPROSATE; BRAIN PROTEIN; DIZOCILPINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ELECTROPHYSIOLOGY; EMBRYO; HIPPOCAMPUS; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; KIDNEY CELL; MALE; NERVE CELL CULTURE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; XENOPUS LAEVIS;

ALCOHOL DETERRENTS; ANIMALS; BRAIN; CELL LINE; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; MALE; MEMANTINE; N-METHYLASPARTATE; NEURONS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; TAURINE; XENOPUS;

EID: 0035001893     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00008-9     Document Type: Article

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