Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism

Journal of Psychiatric Research

Volumn 39, Issue 5, 2005, Pages 545-551

  Kiefer, Falk ^a,b   Jahn, Holger ^b   Otte, Christian ^b   Demiralay, Cüneyt ^b   Wolf, Karsten ^b   Wiedemann, Klaus ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Acamprosate; Addiction; Alcohol; Craving; Leptin; Naltrexone

Indexed keywords

ACAMPROSATE; LEPTIN; NALTREXONE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ANALYTIC METHOD; APPETITE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; FEMALE; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SELF CONCEPT; WITHDRAWAL SYNDROME;

EID: 21344431845     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2004.11.005     Document Type: Article

References (27)

1. R.S. Ahima, and S.Y. Osei Leptin signaling Physiology and Behavior 81 2 2004 223 241
2. L.A. Campfield, F.J. Smith, Y. Guisez, R. Devos, and P. Burn Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546 549
3. W. Fan, B.A. Boston, R.A. Kesterson, V.J. Hruby, and R.D. Cone Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature 385 1997 165 168
4. S. Fulton, B. Woodside, and P. Shizgal Modulation of brain reward circuitry by leptin Science 287 2000 125 128
5. J.L. Halaas, K.S. Gajiwala, M. Maffei, S.L. Cohen, B.T. Chait, and D. Rabinowitz Weight-reducing effects of the plasma protein encoded by the obese gene Science 269 1995 543 546
6. J. Harvey Leptin: a multifaceted hormone in the central nervous system Molecular Neurobiology 28 3 2003 245 258
7. M.L. Heiman, R.S. Ahima, L.S. Craft, B. Schoner, T.W. Stephens, and J.S. Flier Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress Endocrinology 138 1997 3859 3863
8. J.H. Henriksen, J.J. Holst, S. Moller, K. Brinch, and F. Bendtsen Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal Hepatology 29 1999 1818 1824
9. F. Kiefer, H. Jahn, M. Kellner, D. Naber, and K. Wiedemann Leptin as a possible modulator of craving for alcohol Archives of General Psychiatry 58 2001 509 510
10. F. Kiefer, H. Jahn, M. Jaschinski, R. Holzbach, K. Wolf, and D. Naber Leptin: a modulator of alcohol craving? Biological Psychiatry 49 9 2001 782 787
11. F. Kiefer, H. Jahn, K. Wolf, P. Kampf, K. Knaudt, and K. Wiedemann Free-choice alcohol consumption in mice after application of the appetite regulating peptide leptin Alcoholism-Clinical and Experimental Research 25 2001 787 789
12. F. Kiefer, H. Jahn, T. Tarnaske, H. Helwig, P. Briken, and R. Holzbach Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study Archives of General Psychiatry 60 2003 92 99
13. T. Kraus, U. Reulbach, K. Bayerlein, B. Mugele, T. Hillemacher, and W. Sperling Leptin is associated with craving in females with alcoholism Addiction Biology 9 2004 213 219
14. G.A. Laughlin, A.J. Morales, and S.S. Yen Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia Journal of Clinical Endocrinology and Metabolism 82 1997 1692 1696
15. J. Littleton, S. Mayer, and M. al Qatari Repeated alcohol consumption: implications for craving, kindling and treatment Biological Psychiatry 42 1997 275 276
16. M. Maffei, J. Halaas, E. Ravussin, R.E. Pratley, G.H. Lee, and Y. Zhang Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Nature Medicine 1 1995 1155 1161
17. C.S. Mantzoros, and S.J. Moschos Leptin: in search of role (s) in human physiology and pathophysiology Clinical Endocrinology (Oxf) 49 1998 551 567
18. C.S. Mantzoros, A.D. Liolios, N.A. Tritos, V.G. Kaklamani, D.E. Doulgerakis, and I. Griveas Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men Obesity Research 6 1998 179 186
19. A.J. McCullough, E. Bugianesi, G. Marchesini, and S.C. Kalhan Gender-dependent alterations in serum leptin in alcoholic cirrhosis Gastroenterology 115 1998 947 953
20. J.M. Nicolás, J. Fernández-Solà, F. Fatló, R. Batáller, E. Sacanella, and E. Tobías Increased circulating leptin levels in chronic alcoholism Alcoholism-Clinical and Experimental Research 25 2001 83 88
21. M.A. Pelleymounter, M.J. Cullen, M.B. Baken, R. Hecht, D. Winters, and T. Boone Effects of the obese gene product on body weight regulation in ob/ob mice Science 269 1995 540 543
22. D.D. Rasmussen, B.M. Boldt, C.W. Wilkinson, and D.R. Mitton Chronic daily ethanol and withdrawal: 3. Forebrain pro-opiomelanocortin gene expression and implications for dependence, relapse, and deprivation effect Alcoholism-Clinical and Experimental Research 26 2002 535 546
23. C. Schule, G. Laakmann, T. Baghai, C. Neukam, and M. Soyka Lack of effects of acamprosate on anterior pituitary hormone secretion in healthy subjects Journal of Clinical Psychopharmacology 19 1999 387 389
24. M.W. Schwartz, R.J. Seeley, S.C. Woods, D.S. Weigle, L.A. Campfield, and P. Burn Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus Diabetes 46 1997 2119 2123
25. R. Spanagel, and S.M. Holter Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol and Alcoholism 34 1999 231 243
26. G.S. Wand, and H. Schumann Relationship between plasma adrenocorticotropin, hypothalamic opioid tone, and plasma leptin Journal of Clinical Endocrinology and Metabolism 83 1998 2138 2142
27. F.M. Wurst, S. Alexson, T. Glig, S. Forster, G. Bechtel, and M. Wolfersdorf On the role of leptin in alcohol withdrawal Alcoholism-Clinical and Experimental Research 26 2002 156A