Dioxane and oxathiane nuclei: Suitable substructures for muscarinic agonists

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 886-896

  Piergentili, Alessandro ^a   Quaglia, Wilma ^a   Giannella, Mario ^a   Bello, Fabio Del ^a   Bruni, Bruno ^b   Buccioni, Michela ^a   Carrieri, Antonio ^c   Ciattini, Samuele ^b  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

1,4 Dioxane nucleus; 1,4 Oxathiane nucleus; Muscarinic agonists; Subtype selectivity

Indexed keywords

1,4 DIOXANE DERIVATIVE; 1,4 OXATHIANE; METHYL GROUP; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; RECEPTOR SUBTYPE; SULFONE DERIVATIVE; TRIMETHYL(2 METHYL[1,3]DIOXAN 4 YLMETHYL)AMMONIUM IODIDE; TRIMETHYL(2 METHYL[1,3]DIOXOLAN 4 YLMETHYL)AMMONIUM IODIDE; TRIMETHYL(6 METHYL[1,4]DIOXAN 2 YLMETHYL)AMMONIUM IODIDE; TRIMETHYL(6 METHYL[1,4]OXATHIAN 2 YLMETHYL)AMMONIUM IODIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CIS ISOMER; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; MALE; NONHUMAN; RABBIT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TRANS ISOMER;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART ATRIA; HETEROCYCLIC COMPOUNDS, 1-RING; ILEUM; INDICATORS AND REAGENTS; ISOMERISM; LUNG; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; MUSCARINIC AGONISTS; MUSCLE, SMOOTH; RABBITS; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTOR, MUSCARINIC M4; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 33845325214     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.040     Document Type: Article

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