1,3-Dioxolane-based ligands as a novel class of α1-adrenoceptor antagonists

Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2003, Pages 1504-1511

  Brasili, Livio ^a   Sorbi, Claudia ^a   Franchini, Silvia ^a   Manicardi, Massimo ^a,d   Angeli, Piero ^b   Marucci, Gabriella ^b   Leonardi, Amedeo ^c   Poggesi, Elena ^c  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c Recordati SpA   (Italy)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; LIGAND; NORADRENALIN; PHENYLEPHRINE; PRAZOSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CELL CLONING; CELL MEMBRANE; CHEMICAL MODIFICATION; CHO CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; ISOLATED ORGAN; NONHUMAN; PROTEIN EXPRESSION; RAT; SPLEEN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THORACIC AORTA; VAS DEFERENS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; AORTA, THORACIC; CHO CELLS; CRICETINAE; DIOXOLANES; HUMANS; LIGANDS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA-1; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 0037431380     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021078o     Document Type: Article

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