-
1
-
-
0033738748
-
Will the real Cowden syndrome pleaRe stand up: Revised diagnostic criteria
-
Eng C: Will the real Cowden syndrome pleaRe stand up: revised diagnostic criteria. J Med Genet 2000; 37: 828-830.
-
(2000)
J Med Genet
, vol.37
, pp. 828-830
-
-
Eng, C.1
-
2
-
-
6844252284
-
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
-
Marsh DJ, Coulon V, Lunetta KL et al: Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum Mol Genet 1998; 7: 507-515.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 507-515
-
-
Marsh, D.J.1
Coulon, V.2
Lunetta, K.L.3
-
3
-
-
0042316755
-
PTEN: One gene, many syndromes
-
Ong C: PTEN: one gene, many syndromes. Hum Mutat 2003; 22: 183-198.
-
(2003)
Hum Mutat
, vol.22
, pp. 183-198
-
-
Ong, C.1
-
4
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM: Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998; 280: 1614-1617.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, K.M.6
-
5
-
-
0035835824
-
PTEN: Life as a tumor suppressor
-
Limpson L, Parsons R: PTEN: life as a tumor suppressor. Exp Cell Res 2001; 264: 29-41.
-
(2001)
Exp Cell Res
, vol.264
, pp. 29-41
-
-
Limpson, L.1
Parsons, R.2
-
6
-
-
0035869175
-
PTEN inhibits insulin-stimulated MEK/ MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
-
Weng LP, Smith WM, Brown JL, Eng C: PTEN inhibits insulin-stimulated MEK/ MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model. Hum Mol Genet 2001; 10: 605-616.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 605-616
-
-
Weng, L.P.1
Smith, W.M.2
Brown, J.L.3
Eng, C.4
-
7
-
-
33845999615
-
Essential role for nuclear PTEN in maintaining chromosomal integrity
-
Shen WH, Balajee AS, Wang J et al: Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007; 128: 157-170.
-
(2007)
Cell
, vol.128
, pp. 157-170
-
-
Shen, W.H.1
Balajee, A.S.2
Wang, J.3
-
9
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
Suzuki A, de la Pompa JL, Stambolic V et al: High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 1998; 8: 1169-1178.
-
(1998)
Curr Biol
, vol.8
, pp. 1169-1178
-
-
Suzuki, A.1
de la Pompa, J.L.2
Stambolic, V.3
-
10
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
Podsypanina K, Ellenson LH, Nemes A et al: Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci USA 1999; 96: 1563-1568.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
-
11
-
-
0030728479
-
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
-
Furnari FB, Lin H, Huang HS, Cavenee WK: Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci USA 1997; 94: 12479-12484.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 12479-12484
-
-
Furnari, F.B.1
Lin, H.2
Huang, H.S.3
Cavenee, W.K.4
-
12
-
-
0036278486
-
Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells
-
Davies MA, Kim SJ, Parikh NU, Dong Z, Bucana CD, Gallick GE: Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells. Clin Cancer Res 2002; 8: 1904-1914.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1904-1914
-
-
Davies, M.A.1
Kim, S.J.2
Parikh, N.U.3
Dong, Z.4
Bucana, C.D.5
Gallick, G.E.6
-
13
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stainbolic V, Suzuki A, de la Pompa JL et al: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998; 95: 29-39.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stainbolic, V.1
Suzuki, A.2
de la Pompa, J.L.3
-
14
-
-
0001182707
-
Cowden's disease. A possible new symptom complex with multiple system involvement
-
Lloyd II KM, Dennis M: Cowden's disease. A possible new symptom complex with multiple system involvement. Ann Intern Med 1963; 58: 136-142.
-
(1963)
Ann Intern Med
, vol.58
, pp. 136-142
-
-
Lloyd II, K.M.1
Dennis, M.2
-
15
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
Liaw D, Marsh DJ, Li J et al: Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 1997; 16: 64-67.
-
(1997)
Nat Genet
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
-
16
-
-
0022649866
-
The Cowden syndrome: A clinical and genetic study in 21 patients
-
Starink TM, van der Veen JP, Arwert F et al: The Cowden syndrome: a clinical and genetic study in 21 patients. Clin Genet 1986; 29: 222-233.
-
(1986)
Clin Genet
, vol.29
, pp. 222-233
-
-
Starink, T.M.1
van der Veen, J.P.2
Arwert, F.3
-
17
-
-
0037973471
-
GI polyposis and glycogenic acanthosis of the esophagus associated with PTEN mutation positive Cowden syndrome in the absence of cutaneous manifestations
-
McGarrity TJ, Wagner Baker MJ, Ruggiero FM et al: GI polyposis and glycogenic acanthosis of the esophagus associated with PTEN mutation positive Cowden syndrome in the absence of cutaneous manifestations. Am J Gastroenterol 2003; 98: 1429-1434.
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 1429-1434
-
-
McGarrity, T.J.1
Wagner Baker, M.J.2
Ruggiero, F.M.3
-
18
-
-
0033258497
-
Thyroid pathologic findings in patients with Cowden disease
-
Harach HR, Soubeyran I, Brown A, Bonneau D, Longy M: Thyroid pathologic findings in patients with Cowden disease. Ann Diagn Pathol 1999; 3: 331-340.
-
(1999)
Ann Diagn Pathol
, vol.3
, pp. 331-340
-
-
Harach, H.R.1
Soubeyran, I.2
Brown, A.3
Bonneau, D.4
Longy, M.5
-
19
-
-
0031975070
-
Clinical and pathological features of breast disease in Cowden's syndrome: An underrecognized syndrome with an increased risk of breast cancer
-
Schrager CA, Schneider D, Gruener AC, Tsou HC, Peacocke M: Clinical and pathological features of breast disease in Cowden's syndrome: An underrecognized syndrome with an increased risk of breast cancer. Hum Pathol 1998; 29: 47-53.
-
(1998)
Hum Pathol
, vol.29
, pp. 47-53
-
-
Schrager, C.A.1
Schneider, D.2
Gruener, A.C.3
Tsou, H.C.4
Peacocke, M.5
-
21
-
-
34548839377
-
The spectrum of vascular anomalies in patients with PTEN mutations: Implications for diagnosis and management
-
Tan WH, Baris HN, Burrows PE et al: The spectrum of vascular anomalies in patients with PTEN mutations: Implications for diagnosis and management. J Med Genet 2007; 44: 594-602.
-
(2007)
J Med Genet
, vol.44
, pp. 594-602
-
-
Tan, W.H.1
Baris, H.N.2
Burrows, P.E.3
-
22
-
-
34548817013
-
Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: Results of a clinical study of PTEN mutation carriers
-
Lachlan KL, Lucassen AM, Bunyan D, Temple IK: Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: Results of a clinical study of PTEN mutation carriers. J Med Genet 2007; 44: 579-585.
-
(2007)
J Med Genet
, vol.44
, pp. 579-585
-
-
Lachlan, K.L.1
Lucassen, A.M.2
Bunyan, D.3
Temple, I.K.4
-
23
-
-
0029932884
-
Cowden disease. Report of a family and review
-
Longy M, Lacombe D: Cowden disease. Report of a family and review. Ann Genet 1996; 39: 35-42.
-
(1996)
Ann Genet
, vol.39
, pp. 35-42
-
-
Longy, M.1
Lacombe, D.2
-
24
-
-
35248898105
-
Susceptibility to breast cancer: Hereditary syndromes and low penetrance genes
-
Nusbaum R, Vogel KJ, Ready K: Susceptibility to breast cancer: hereditary syndromes and low penetrance genes. Breast Dis 2006; 27: 21-50.
-
(2006)
Breast Dis
, vol.27
, pp. 21-50
-
-
Nusbaum, R.1
Vogel, K.J.2
Ready, K.3
-
25
-
-
0035088435
-
Male breast cancer in Cowden syndrome patients with germline PTEN mutations
-
Fackenthal JD, Marsh DJ, Richardson AL et al: Male breast cancer in Cowden syndrome patients with germline PTEN mutations. J Med Genet 2001; 38: 159-164.
-
(2001)
J Med Genet
, vol.38
, pp. 159-164
-
-
Fackenthal, J.D.1
Marsh, D.J.2
Richardson, A.L.3
-
26
-
-
2342458960
-
WIll the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome
-
Pilarski R, Eng C: WIll the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome. J Med Genet 2004; 41: 323-326.
-
(2004)
J Med Genet
, vol.41
, pp. 323-326
-
-
Pilarski, R.1
Eng, C.2
-
27
-
-
0032853452
-
PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
-
Marsh DJ, Kum JB, Lunetta KL et al: PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Hum Mol Genet 1999; 8: 1461-1472.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 1461-1472
-
-
Marsh, D.J.1
Kum, J.B.2
Lunetta, K.L.3
-
28
-
-
0041742215
-
Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway
-
Zhou XP, Waite KA, Pilarski R et al: Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway. Am J Hum Genet 2003; 73 404-411.
-
(2003)
Am J Hum Genet
, vol.73
, pp. 404-411
-
-
Zhou, X.P.1
Waite, K.A.2
Pilarski, R.3
-
29
-
-
39049086391
-
MicroRNA expression profiling in human ovarian cancer: MiR-214 induces cell survival and cisplatin resistance by targeting PTEN
-
Yang H, Kong W, He L et al: MicroRNA expression profiling in human ovarian cancer: MiR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res 2008; 68: 425-433.
-
(2008)
Cancer Res
, vol.68
, pp. 425-433
-
-
Yang, H.1
Kong, W.2
He, L.3
-
30
-
-
33845977965
-
Ubiquitination regulates PTEN nuclear import and tumor suppression
-
Trotman LC, Wang X, Alimonti A et al: Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 2007; 128: 141-156.
-
(2007)
Cell
, vol.128
, pp. 141-156
-
-
Trotman, L.C.1
Wang, X.2
Alimonti, A.3
-
31
-
-
33845991111
-
NEDD4-1 is a protooncogenic ubiquitin ligase for PTEN
-
Wang X, Trotman LC, Koppie T et al: NEDD4-1 is a protooncogenic ubiquitin ligase for PTEN. Cell 2007; 128: 129-139.
-
(2007)
Cell
, vol.128
, pp. 129-139
-
-
Wang, X.1
Trotman, L.C.2
Koppie, T.3
-
32
-
-
33746114249
-
Epigenetic silencing of the PTEN gene in melanoma
-
Mirmohammadsadegh A, Marini A, Nambiar S et al: Epigenetic silencing of the PTEN gene in melanoma. Cancer Res 2006; 66: 6546-6552.
-
(2006)
Cancer Res
, vol.66
, pp. 6546-6552
-
-
Mirmohammadsadegh, A.1
Marini, A.2
Nambiar, S.3
-
33
-
-
33745251706
-
Distinct expression profiles for PTEN transcript and its splice variants in Cowden syndrome and Bannayan-Rdey-Ruvalcaba syndrome
-
Sarquis MS, Agrawal S, Shen L, Pilarski R, Zhou XP, Eng C: Distinct expression profiles for PTEN transcript and its splice variants in Cowden syndrome and Bannayan-Rdey-Ruvalcaba syndrome. Am J Hum Genet 2006; 79: 23-30.
-
(2006)
Am J Hum Genet
, vol.79
, pp. 23-30
-
-
Sarquis, M.S.1
Agrawal, S.2
Shen, L.3
Pilarski, R.4
Zhou, X.P.5
Eng, C.6
-
34
-
-
33144470077
-
Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer
-
Agrawal S, Eng C: Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer. Hum Mol Genet 2006; 15: 777-787.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 777-787
-
-
Agrawal, S.1
Eng, C.2
-
35
-
-
33845875992
-
Cancer phenomics: REr and PTEN as illustrative models
-
Zbuk KM, Eng C: Cancer phenomics: REr and PTEN as illustrative models. Nat Rev Cancer 2007; 7: 35-45.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 35-45
-
-
Zbuk, K.M.1
Eng, C.2
-
36
-
-
0242522403
-
Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults
-
Zhou XP. Marsh DJ, Morrison CD et al: Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults. Am J Hum Genet 2003; 73: 1191-1198.
-
(2003)
Am J Hum Genet
, vol.73
, pp. 1191-1198
-
-
Zhou, X.P.1
Marsh, D.J.2
Morrison, C.D.3
-
37
-
-
0026539260
-
Recurrent Lhermitte-Duclos disease: Report of two cases and association with Cowden's disease
-
Williams III DW, Elster AD, Ginsberg LE, Stanton C: Recurrent Lhermitte-Duclos disease: Report of two cases and association with Cowden's disease. AJNR Am J Neuroradiol 1992; 13: 287-290.
-
(1992)
AJNR Am J Neuroradiol
, vol.13
, pp. 287-290
-
-
Williams III, D.W.1
Elster, A.D.2
Ginsberg, L.E.3
Stanton, C.4
-
38
-
-
20144387454
-
Lhermitte-Duclos disease: A report of 31 cases with immunohistochemical analysis of the PTEN/AKT/ mTOR pathway
-
Abel TW, Baker SJ, FAaser MM et al: Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/ mTOR pathway. J Neuropathol Exp Neurol 2005; 64: 341-349.
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 341-349
-
-
Abel, T.W.1
Baker, S.J.2
FAaser, M.M.3
-
39
-
-
0015094329
-
Lipomatosis, angiomatosis, and macrencephalia. A previously undescribed congenital syndrome
-
Bannayan GA: Lipomatosis, angiomatosis, and macrencephalia. A previously undescribed congenital syndrome. Arch Pathol 1971; 92: 1-5.
-
(1971)
Arch Pathol
, vol.92
, pp. 1-5
-
-
Bannayan, G.A.1
-
40
-
-
0024817610
-
Macrocephaly, multiple lipomas, and hemangiomata (Bannayan-Zonana syndrome): Genetic heterogeneity or autosomal dominant locus with at least two different allelic forms?
-
Moretti-Ferreira D, Koiffmann CP, Souza DH, Diament AJ, Wajntal A: Macrocephaly, multiple lipomas, and hemangiomata (Bannayan-Zonana syndrome): Genetic heterogeneity or autosomal dominant locus with at least two different allelic forms? Am J Med Genet 1989; 34: 548-551.
-
(1989)
Am J Med Genet
, vol.34
, pp. 548-551
-
-
Moretti-Ferreira, D.1
Koiffmann, C.P.2
Souza, D.H.3
Diament, A.J.4
Wajntal, A.5
-
41
-
-
0021676078
-
Macrocephaly with hamartomas: Bannayan-Zonana syndrome
-
Miles JH, Zonana J, McFarlane J, Aleck KA, Bawle E: Macrocephaly with hamartomas: Bannayan-Zonana syndrome. Am J Med Genet 1984; 19 225-234.
-
(1984)
Am J Med Genet
, vol.19
, pp. 225-234
-
-
Miles, J.H.1
Zonana, J.2
McFarlane, J.3
Aleck, K.A.4
Bawle, E.5
-
42
-
-
0026748713
-
Bannayan-Zonana syndrome associated with lipomas, hemangiomas, and lymphangiomas
-
Hayashi Y, Ohi R, Tomita Y, Chiba T, Matsumoto Y: Bannayan-Zonana syndrome associated with lipomas, hemangiomas, and lymphangiomas. J Pediatr Surg 1992; 27: 722-723.
-
(1992)
J Pediatr Surg
, vol.27
, pp. 722-723
-
-
Hayashi, Y.1
Ohi, R.2
Tomita, Y.3
Chiba, T.4
Matsumoto, Y.5
-
43
-
-
0035138678
-
The spectrum and evolution of phenotypic findings in PTEN mutation positive cases of Bannayan-Riley-Ruvalcaba syndrome
-
Parisi MA, Dinulos MB, Leppig KA, Sybert VP, Eng C, Hudgins L: The spectrum and evolution of phenotypic findings in PTEN mutation positive cases of Bannayan-Riley-Ruvalcaba syndrome. J Med Genet 2001; 38: 52-58.
-
(2001)
J Med Genet
, vol.38
, pp. 52-58
-
-
Parisi, M.A.1
Dinulos, M.B.2
Leppig, K.A.3
Sybert, V.P.4
Eng, C.5
Hudgins, L.6
-
44
-
-
0020534650
-
The proteus syndrome. Partial gigantism of the hands and/or feet, nevi, hemihypertrophy, subcutaneous tumors, macrocephaly or other skull anomalies and possible accelerated growth and visceral affections
-
Wiedemann HR, Burgio GR, Aldenhoff P, Kunze J, Kaufmann HJ, Schirg E: The proteus syndrome. Partial gigantism of the hands and/or feet, nevi, hemihypertrophy, subcutaneous tumors, macrocephaly or other skull anomalies and possible accelerated growth and visceral affections. Eur J Pediatr 1983; 140: 5-12.
-
(1983)
Eur J Pediatr
, vol.140
, pp. 5-12
-
-
Wiedemann, H.R.1
Burgio, G.R.2
Aldenhoff, P.3
Kunze, J.4
Kaufmann, H.J.5
Schirg, E.6
-
47
-
-
0035928416
-
Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes
-
Zhou X, Hampel H, Thiele H et al: Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes. Lancet 2001; 358: 210-211.
-
(2001)
Lancet
, vol.358
, pp. 210-211
-
-
Zhou, X.1
Hampel, H.2
Thiele, H.3
-
48
-
-
0036918288
-
Germline mutation of the tumour suppressor PTEN in Proteus syndrome
-
Smith JM, Kirk EP. Theodosopoulos G et al: Germline mutation of the tumour suppressor PTEN in Proteus syndrome. J Med Genet 2002; 39: 937-940.
-
(2002)
J Med Genet
, vol.39
, pp. 937-940
-
-
Smith, J.M.1
Kirk, E.P.2
Theodosopoulos, G.3
-
49
-
-
0035895042
-
PTEN mutations and proteus syndrome
-
Biesecker LG, Rosenberg MJ, Vacha S, Turner JT, Cohen MM: PTEN mutations and proteus syndrome. Lancet, 2001; 358: 2079-2080.
-
(2001)
Lancet
, vol.358
, pp. 2079-2080
-
-
Biesecker, L.G.1
Rosenberg, M.J.2
Vacha, S.3
Turner, J.T.4
Cohen, M.M.5
-
50
-
-
4644233466
-
Mutation analysis of the tumor suppressor PTEN and the glypican 3 (GPC3) gene in patients diagnosed with Proteus; syndrome
-
Thiffault I, Schwartz CE, Der Kaloustian V, Foulkes WD: Mutation analysis of the tumor suppressor PTEN and the glypican 3 (GPC3) gene in patients diagnosed with Proteus; syndrome. Am J Med Genet A 2004; 130: 123-127.
-
(2004)
Am J Med Genet A
, vol.130
, pp. 123-127
-
-
Thiffault, I.1
Schwartz, C.E.2
Der Kaloustian, V.3
Foulkes, W.D.4
-
51
-
-
34247353747
-
Type 2 segmental Cowden disease vs Proteus syndrome
-
Happle R: Type 2 segmental Cowden disease vs Proteus syndrome. Br J Dermatol 2007; 156: 1089-1090.
-
(2007)
Br J Dermatol
, vol.156
, pp. 1089-1090
-
-
Happle, R.1
-
52
-
-
33947405634
-
LineaA Cowden nevus: A new distinct epidermal nevus
-
Happle R: LineaA Cowden nevus: a new distinct epidermal nevus. Eur J Dermatol 2007; 17: 133-136.
-
(2007)
Eur J Dermatol
, vol.17
, pp. 133-136
-
-
Happle, R.1
-
53
-
-
34250708389
-
Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity
-
Caux F, Plauchu H, Chibon F et al: Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity. Eur J Hum Genet 2007; 15: 767-773.
-
(2007)
Eur J Hum Genet
, vol.15
, pp. 767-773
-
-
Caux, F.1
Plauchu, H.2
Chibon, F.3
-
54
-
-
34250812575
-
Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly
-
Buxbaum JD, Cai G, Chaste P et al: Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am J Med Genet B Netappsychiatr Genet 2007; 144: 484-491.
-
(2007)
Am J Med Genet B Netappsychiatr Genet
, vol.144
, pp. 484-491
-
-
Buxbaum, J.D.1
Cai, G.2
Chaste, P.3
-
55
-
-
0035666018
-
A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association
-
Reardon W, Zhou XP, Eng C: A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association. J Med Genet 2001; 38: 820-823.
-
(2001)
J Med Genet
, vol.38
, pp. 820-823
-
-
Reardon, W.1
Zhou, X.P.2
Eng, C.3
-
56
-
-
27744511296
-
Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis
-
Sweet K, Willis J, Zhou XP et al: Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. JAMA 2005; 294: 2465-2473.
-
(2005)
JAMA
, vol.294
, pp. 2465-2473
-
-
Sweet, K.1
Willis, J.2
Zhou, X.P.3
-
57
-
-
42549147553
-
Large genomic deletions of Smad4, Bmpr1a and Pten in juvenile polyposis
-
van Hattem WA, Brosens; LA, de Leng WW et al: Large genomic deletions of Smad4, Bmpr1a and Pten in juvenile polyposis. Gut 2008; 57 (5): 623-627.
-
(2008)
Gut
, vol.57
, Issue.5
, pp. 623-627
-
-
van Hattem, W.A.1
Brosens, L.A.2
de Leng, W.W.3
-
58
-
-
0035913275
-
Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation
-
Meijers-Heijboer H, van Geel B, van Putten WL et al: Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation. N Engl J Med 2001; 345: 159-164.
-
(2001)
N Engl J Med
, vol.345
, pp. 159-164
-
-
Meijers-Heijboer, H.1
van Geel, B.2
van Putten, W.L.3
-
59
-
-
0035824069
-
Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers
-
Hartmann LC, Sellers TA, Schaid DJ et al: Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers. J Natl Cancer Inst 2001; 93: 1633-1637.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1633-1637
-
-
Hartmann, L.C.1
Sellers, T.A.2
Schaid, D.J.3
-
60
-
-
27944492407
-
Tamoxifen for the prevention of breast cancer: Current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study
-
Fisher B, Costantino JP, Wickerham DL et al: Tamoxifen for the prevention of breast cancer: Current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study. J Natl Cancer Inst 2005; 97: 1652-1662.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1652-1662
-
-
Fisher, B.1
Costantino, J.P.2
Wickerham, D.L.3
-
61
-
-
33745249570
-
Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial
-
Vogel VG, Costantino JP, Wickerham DL et al: Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA 2006; 295: 2727-2741.
-
(2006)
JAMA
, vol.295
, pp. 2727-2741
-
-
Vogel, V.G.1
Costantino, J.P.2
Wickerham, D.L.3
-
62
-
-
0036735346
-
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
-
Shi Y, Gera J, Hu L et al: Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res 2002; 62: 5027-5034.
-
(2002)
Cancer Res
, vol.62
, pp. 5027-5034
-
-
Shi, Y.1
Gera, J.2
Hu, L.3
-
63
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat MS, Mellinghoff IK, Tran C et al: Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001; 98: 10314-10319.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
-
64
-
-
0034790016
-
MTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
Yu K, Toral-Barza L, Discafani C et al: MTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 2001; 8: 249-258.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 249-258
-
-
Yu, K.1
Toral-Barza, L.2
Discafani, C.3
-
66
-
-
38049169559
-
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangio-leiomyomatosis
-
Bissler JJ, McCormack FX, Young IR et al: Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangio-leiomyomatosis. N Engi J Med 2008; 358: 140-151.
-
(2008)
N Engi J Med
, vol.358
, pp. 140-151
-
-
Bissler, J.J.1
McCormack, F.X.2
Young, I.R.3
-
67
-
-
44649203072
-
Rapamycin treatment for a child with germline PTEN mutation
-
Marsh DJ, Trahair TN, Martin JL et al: Rapamycin treatment for a child with germline PTEN mutation. Nat Clin Pract Oncol 2008; 5 357-361.
-
(2008)
Nat Clin Pract Oncol
, vol.5
, pp. 357-361
-
-
Marsh, D.J.1
Trahair, T.N.2
Martin, J.L.3
-
68
-
-
0034651983
-
Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
-
Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K: Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 2000; 101: 660-667.
-
(2000)
Circulation
, vol.101
, pp. 660-667
-
-
Fujio, Y.1
Nguyen, T.2
Wencker, D.3
Kitsis, R.N.4
Walsh, K.5
-
69
-
-
14944381279
-
Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications
-
Zdychova J, Komers R: Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications. Physiol Res 2005; 54: 1-16.
-
(2005)
Physiol Res
, vol.54
, pp. 1-16
-
-
Zdychova, J.1
Komers, R.2
-
70
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun SY, Rosenberg LM, Wang X et al: Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005; 65: 7052-7058.
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
-
71
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB et al: MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006; 66: 1500-1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
72
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
-
Wan X, Harkavy B, Shen N, Grohar P, Heiman LJ: Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007; 26: 1932-1940.
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
Grohar, P.4
Heiman, L.J.5
-
73
-
-
38849208347
-
Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma
-
Cloughesy TF, Yoshimoto K, Nghiemphu P et al: Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 2008, 5: E8.
-
(2008)
PLoS Med
, vol.5
-
-
Cloughesy, T.F.1
Yoshimoto, K.2
Nghiemphu, P.3
-
74
-
-
34548596728
-
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
-
Fan QW, Cheng CK, Nicolaides TP et al: A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res 2007; 67: 7960-7965.
-
(2007)
Cancer Res
, vol.67
, pp. 7960-7965
-
-
Fan, Q.W.1
Cheng, C.K.2
Nicolaides, T.P.3
-
75
-
-
54549113475
-
-
Papadopoulos KP, Markman B, Tabernero J et al: A phase I dose-escalation study of the safety, parmacokinetics (PK), and pharmacodynamics (PD) of a novel PI3K inhibitor, XL765, administered orally to patients (pts) with advanced solid tumors. J Clin Oncol 2008; 26: (20 May suppl; abstract 3510).
-
Papadopoulos KP, Markman B, Tabernero J et al: A phase I dose-escalation study of the safety, parmacokinetics (PK), and pharmacodynamics (PD) of a novel PI3K inhibitor, XL765, administered orally to patients (pts) with advanced solid tumors. J Clin Oncol 2008; 26: (20 May suppl; abstract 3510).
-
-
-
-
76
-
-
17644365438
-
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
-
Beilina A, Van Der Brug M, Ahmad R et al: Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proc Natl Acad Sci USA 2005; 102: 5703-5708.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 5703-5708
-
-
Beilina, A.1
Van Der Brug, M.2
Ahmad, R.3
-
77
-
-
0035958558
-
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
-
Unoki M, Nakamura Y: Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene 2001; 20 4457-4465.
-
(2001)
Oncogene
, vol.20
, pp. 4457-4465
-
-
Unoki, M.1
Nakamura, Y.2
|