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Volumn 6, Issue 5, 2008, Pages 325-332

Anticancer mechanisms and researches of isothiocyanates

Author keywords

Anticancer; Isothiocyanates; Mechanisms; Researches

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; 3 MORPHOLINOPROPYL ISOTHIOCYANATE; 4 PHENYLBUTYL ISOTHIOCYANATE; 6 (METHYLSULFINYL)HEXYL ISOTHIOCYANATE; 6 PHENYLHEXYL ISOTHIOCYANATE; ANTINEOPLASTIC AGENT; BENZYL ISOTHIOCYANATE; CISPLATIN; CYCLOOXYGENASE 2; DOXORUBICIN; ETHYL 4 ISOTHIOCYANATOBUTANOATE; ISOTHIOCYANIC ACID; ISOTHIOCYANIC ACID DERIVATIVE; PHENETHYL ISOTHIOCYANATE; PHENYLMETHYL ISOTHIOCYANATE; SULFORAPHANE; UNCLASSIFIED DRUG;

EID: 54449083761     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.3724/SP.J.1009.2008.00325     Document Type: Review
Times cited : (14)

References (60)
  • 1
    • 0035527472 scopus 로고    scopus 로고
    • Cruciferous vegetables and cancer prevention [J]
    • Murillo G, Mehta RG. Cruciferous vegetables and cancer prevention [J]. Nutr Cancer, 2001, 41(1-2): 17-28.
    • (2001) Nutr Cancer , vol.41 , Issue.1-2 , pp. 17-28
    • Murillo, G.1    Mehta, R.G.2
  • 2
    • 0035808553 scopus 로고    scopus 로고
    • The chemical diversity and distribution of glucosinolates and isothiocyanates among plants [J]
    • Fahey JW, Zalcmann AT, Talalay P. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants [J]. Phytochemistry, 2001, 56(1): 5-51.
    • (2001) Phytochemistry , vol.56 , Issue.1 , pp. 5-51
    • Fahey, J.W.1    Zalcmann, A.T.2    Talalay, P.3
  • 3
    • 0035204635 scopus 로고    scopus 로고
    • Effects of benzyl isothiocyanate on rat and human cytochromes P450: Identification of metabolites formed by P450 2B1[J]
    • Goosen TC, Mills DE, Hollenberg PF. Effects of benzyl isothiocyanate on rat and human cytochromes P450: Identification of metabolites formed by P450 2B1[J]. Pharmacol Exp Ther, 2001, 296: 198-206.
    • (2001) Pharmacol Exp Ther , vol.296 , pp. 198-206
    • Goosen, T.C.1    Mills, D.E.2    Hollenberg, P.F.3
  • 4
    • 0034650803 scopus 로고    scopus 로고
    • Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: Correlation of enzyme induction with the formation of reactive oxygen intermediates [J]
    • Nakamura Y, Ohigashi H, Masuda S, et al. Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: Correlation of enzyme induction with the formation of reactive oxygen intermediates [J]. Cancer Res, 2000, 60(2): 219-225.
    • (2000) Cancer Res , vol.60 , Issue.2 , pp. 219-225
    • Nakamura, Y.1    Ohigashi, H.2    Masuda, S.3
  • 5
    • 12744278308 scopus 로고    scopus 로고
    • Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk [J]
    • Joseph MA, Moysich KB, Freudenheim JL, et al. Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk [J]. Nutr Cancer, 2004, 50(2): 206-213.
    • (2004) Nutr Cancer , vol.50 , Issue.2 , pp. 206-213
    • Joseph, M.A.1    Moysich, K.B.2    Freudenheim, J.L.3
  • 6
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements [J]
    • Itoh K, Chiba T, Takahashi S, et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements [J]. Biochem Biophys Res Gommun, 1997, 236(2): 313-322.
    • (1997) Biochem Biophys Res Gommun , vol.236 , Issue.2 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3
  • 7
    • 0036240610 scopus 로고    scopus 로고
    • Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive Agents: Role of antioxidant response element-like sequences in the nrf2 promoter [J]
    • Kwak MK, Itoh K, Yamamoto M, et al. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive Agents: Role of antioxidant response element-like sequences in the nrf2 promoter [J]. Mol Cell Biol, 2002, 22(9): 2883-2892.
    • (2002) Mol Cell Biol , vol.22 , Issue.9 , pp. 2883-2892
    • Kwak, M.K.1    Itoh, K.2    Yamamoto, M.3
  • 8
    • 0036007313 scopus 로고    scopus 로고
    • Role of NRF2 in protection against hyperoxic lung injury in mice [J]
    • Cho HY, Jedlicka AE, Reddy SPM, et al. Role of NRF2 in protection against hyperoxic lung injury in mice [J]. Respir Cell Mol Biol, 2002, 26(2): 175-182.
    • (2002) Respir Cell Mol Biol , vol.26 , Issue.2 , pp. 175-182
    • Cho, H.Y.1    Jedlicka, A.E.2    Reddy, S.P.M.3
  • 9
    • 0035260034 scopus 로고    scopus 로고
    • Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione[J]
    • Kwak MK, Itoh K, Yamamoto M, et al. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione[J]. Mol Med, 2001, 7(2): 135-145.
    • (2001) Mol Med , vol.7 , Issue.2 , pp. 135-145
    • Kwak, M.K.1    Itoh, K.2    Yamamoto, M.3
  • 10
    • 4444315787 scopus 로고    scopus 로고
    • A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway [J]
    • Zhang YS, Gordon GB. A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway [J]. Mol Cancer Ther, 2004, 3: 885-893.
    • (2004) Mol Cancer Ther , vol.3 , pp. 885-893
    • Zhang, Y.S.1    Gordon, G.B.2
  • 11
    • 40949104732 scopus 로고    scopus 로고
    • 3-morpholinoproply isothiocyanate (3MP-ITC) is a novel synthetic isothiocyanate that strongly induces the antioxidant response element (ARE)-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo[J]
    • 10.1093/carcin/bgm208
    • Keum YS, Chang PP-J, Kwon KH, et al. 3-morpholinoproply isothiocyanate (3MP-ITC) is a novel synthetic isothiocyanate that strongly induces the antioxidant response element (ARE)-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo[J]. Carcinogenesis, 2007,10.1093/carcin/bgm208.
    • (2007) Carcinogenesis
    • Keum, Y.S.1    Chang, P.P.-J.2    Kwon, K.H.3
  • 12
    • 0032007312 scopus 로고    scopus 로고
    • Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity [J]
    • Rong Y, Sandhya M, Kevin J. et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity [J]. Cancer Res, 1998, 58: 402-408.
    • (1998) Cancer Res , vol.58 , pp. 402-408
    • Rong, Y.1    Sandhya, M.2    Kevin, J.3
  • 13
    • 32944475745 scopus 로고    scopus 로고
    • Sulforaphane sensitizes tumor necrosisFactor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5 [J]
    • Kim H, Kim,EH, EomYW, et al. Sulforaphane sensitizes tumor necrosisFactor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5 [J]. Cancer Res, 2006, 66: 1740-1750.
    • (2006) Cancer Res , vol.66 , pp. 1740-1750
    • Kim, H.1    Kim, E.H.2    EomYW3
  • 14
    • 34447120145 scopus 로고    scopus 로고
    • The Role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells [J]
    • Mi LX, Wang XT, Govind S, et al. The Role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells [J]. Cancer Res, 2007, 67: 6409-6416.
    • (2007) Cancer Res , vol.67 , pp. 6409-6416
    • Mi, L.X.1    Wang, X.T.2    Govind, S.3
  • 15
    • 1942451371 scopus 로고    scopus 로고
    • Selected isothiocyanates rapidly induce growth inhibition of cancer cells [J]
    • Zhang YS, Tang L, Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells [J]. Mol Cancer Ther, 2003, 2: 1045-1052.
    • (2003) Mol Cancer Ther , vol.2 , pp. 1045-1052
    • Zhang, Y.S.1    Tang, L.2    Gonzalez, V.3
  • 16
    • 33645021315 scopus 로고    scopus 로고
    • Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G(1) cell cycle arrest [J]
    • Suh SJ, Moon SK, Kim CH. Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G(1) cell cycle arrest [J]. Int Immunopharmacol, 2006, 6(5): 854-861.
    • (2006) Int Immunopharmacol , vol.6 , Issue.5 , pp. 854-861
    • Suh, S.J.1    Moon, S.K.2    Kim, C.H.3
  • 17
    • 33846798049 scopus 로고    scopus 로고
    • Antipro- liferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells [J]
    • Chaudhuri D, Orsulic S, Badithe T. Antipro- liferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells [J]. Mol Cancer Ther, 2007, 6(1): 334-345.
    • (2007) Mol Cancer Ther , vol.6 , Issue.1 , pp. 334-345
    • Chaudhuri, D.1    Orsulic, S.2    Badithe, T.3
  • 18
    • 0027200035 scopus 로고
    • Ethyl 4-isothiocyanatobutanoate-antiproliferative activity in Vitro and in vivo [J]
    • Horakova K, Jantova S, Stred'ansky M, et al. Ethyl 4-isothiocyanatobutanoate-antiproliferative activity in Vitro and in vivo [J]. Anticancer Drugs, 1993, 4(3): 369-375.
    • (1993) Anticancer Drugs , vol.4 , Issue.3 , pp. 369-375
    • Horakova, K.1    Jantova, S.2    Stred'ansky, M.3
  • 21
    • 27644553527 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells [J]
    • Cho SD, Li G, Hu H, et al. Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells [J]. Nutr Cancer, 2005, 52(2): 213-224.
    • (2005) Nutr Cancer , vol.52 , Issue.2 , pp. 213-224
    • Cho, S.D.1    Li, G.2    Hu, H.3
  • 22
    • 4544311831 scopus 로고    scopus 로고
    • Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells [J]
    • Srivastava SK, Singh SV. Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells [J]. Carcinogenesis, 2004, 5: 1701-1709.
    • (2004) Carcinogenesis , vol.5 , pp. 1701-1709
    • Srivastava, S.K.1    Singh, S.V.2
  • 23
    • 1342326771 scopus 로고    scopus 로고
    • Sulforaphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes ann [J]
    • Fimognari C, Nusse M, BERTI F, et al. Sulforaphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes ann [J]. N Y Acad Sci, 2003, 1010: 393-398.
    • (2003) N Y Acad Sci , vol.1010 , pp. 393-398
    • Fimognari, C.1    Nusse, M.2    BERTI, F.3
  • 24
    • 34247622975 scopus 로고    scopus 로고
    • Effect of sulforaphane on cell growth, G(o)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells [J]
    • Shan Y, Sun C, Zhao X, et al. Effect of sulforaphane on cell growth, G(o)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells [J]. Int J Oncol, 2006, 29(4): 883-888.
    • (2006) Int J Oncol , vol.29 , Issue.4 , pp. 883-888
    • Shan, Y.1    Sun, C.2    Zhao, X.3
  • 25
    • 85193617690 scopus 로고    scopus 로고
    • A diet of an isothiocyanate metabollte from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest [J]
    • Chiao JW, Wu H, Ramaswamy G, et al. A diet of an isothiocyanate metabollte from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest [J].AACR Meeting Abstracts, 2004, 2004: 166.
    • (2004) AACR Meeting Abstracts , vol.2004 , pp. 166
    • Chiao, J.W.1    Wu, H.2    Ramaswamy, G.3
  • 26
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase [J]
    • Myzak MC, Karplus PA, Chung FL, et al. A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase [J]. Cancer Res, 2004, 64: 5767-5774.
    • (2004) Cancer Res , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3
  • 27
    • 33846838750 scopus 로고    scopus 로고
    • Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human [J]
    • Myzak MC, Tong P, Dashwood WM, et al. Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human [J]. Subjects Exp Biol Med, 2007, 232: 227-234.
    • (2007) Subjects Exp Biol Med , vol.232 , pp. 227-234
    • Myzak, M.C.1    Tong, P.2    Dashwood, W.M.3
  • 28
    • 85193619153 scopus 로고    scopus 로고
    • Phenolhexyl isothiocyanate, a new histone deacetylase inhibitor, can prevent tumor formation and inhibit leukemia cell growth in vivo [J]
    • Lu LL, Ma XD, Becklemisheva A, et al. Phenolhexyl isothiocyanate, a new histone deacetylase inhibitor, can prevent tumor formation and inhibit leukemia cell growth in vivo [J]. Blood (ASH Annual Meeting Abstracts), 2005, 106: 4625.
    • (2005) Blood (ASH Annual Meeting Abstracts) , vol.106 , pp. 4625
    • Lu, L.L.1    Ma, X.D.2    Becklemisheva, A.3
  • 29
    • 33645822781 scopus 로고    scopus 로고
    • Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells [J]
    • Beklemisheva AA, Fang Y, Feng J, Ma X, et al. Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells [J]. Anticancer Res, 2006, 26(2A): 1225-1230.
    • (2006) Anticancer Res , vol.26 , Issue.2 A , pp. 1225-1230
    • Beklemisheva, A.A.1    Fang, Y.2    Feng, J.3    Ma, X.4
  • 30
    • 33846217828 scopus 로고    scopus 로고
    • Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer [J]
    • Wang LG, Beklemisheva A, Liu XM, et al. Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer [J]. Mol Carcinog, 2007, 46(1): 24-31.
    • (2007) Mol Carcinog , vol.46 , Issue.1 , pp. 24-31
    • Wang, L.G.1    Beklemisheva, A.2    Liu, X.M.3
  • 31
    • 27744433506 scopus 로고    scopus 로고
    • Inhibition of lipopolysacchride-induced cyclooxygenase-2 transcription by 6-(methyl- sulfinyl) hexyl isothiocyanate, a chemopreventive compound from Wasabia japonica (Miq.) Matsumura, in mouse macrophages [J]
    • Uto T, Fujii M, Hou DX. Inhibition of lipopolysacchride-induced cyclooxygenase-2 transcription by 6-(methyl- sulfinyl) hexyl isothiocyanate, a chemopreventive compound from Wasabia japonica (Miq.) Matsumura, in mouse macrophages [J]. Biochem Pharmacol, 2005, 70(12): 1772-84.
    • (2005) Biochem Pharmacol , vol.70 , Issue.12 , pp. 1772-1784
    • Uto, T.1    Fujii, M.2    Hou, D.X.3
  • 32
    • 0035943597 scopus 로고    scopus 로고
    • Nuclear factor κB is amolecular target for sulforaphane-mediated anti- infammatory mechanisms [J]
    • Heiss K, Herhaus C, Klimo K, et al. Nuclear factor κB is amolecular target for sulforaphane-mediated anti- infammatory mechanisms [J]. Biol Chem, 2001, 276(34): 32008-32015.
    • (2001) Biol Chem , vol.276 , Issue.34 , pp. 32008-32015
    • Heiss, K.1    Herhaus, C.2    Klimo, K.3
  • 33
    • 33644869177 scopus 로고    scopus 로고
    • Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappa B [J]
    • Kim SJ, Kang SY, Shin HH, et al. Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappa B [J]. Mol Cells, 2005, 20(3): 364-370.
    • (2005) Mol Cells , vol.20 , Issue.3 , pp. 364-370
    • Kim, S.J.1    Kang, S.Y.2    Shin, H.H.3
  • 34
    • 0034008927 scopus 로고    scopus 로고
    • Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages[J]
    • Wadleigh DJ, Reddy ST, Kopp E, et al. Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages[J]. Biol Chem, 2000, 275(9): 6259-6266.
    • (2000) Biol Chem , vol.275 , Issue.9 , pp. 6259-6266
    • Wadleigh, D.J.1    Reddy, S.T.2    Kopp, E.3
  • 35
    • 0031964618 scopus 로고    scopus 로고
    • Nuclear targeted suppression of NF-kappa B activity by the novel quinone derivative E3330 [J]
    • Hiramoto M, Shimizu N, Sugimoto K, et al. Nuclear targeted suppression of NF-kappa B activity by the novel quinone derivative E3330 [J]. J Immunol, 1998, 160(2): 810-819.
    • (1998) J Immunol , vol.160 , Issue.2 , pp. 810-819
    • Hiramoto, M.1    Shimizu, N.2    Sugimoto, K.3
  • 36
    • 33947244444 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo [J]
    • Xiao D, Singh SV. Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo [J]. Cancer Res, 2007, 67(5): 2239-46
    • (2007) Cancer Res , vol.67 , Issue.5 , pp. 2239-2246
    • Xiao, D.1    Singh, S.V.2
  • 37
    • 33748963952 scopus 로고    scopus 로고
    • Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis [J]
    • Asakage M, Tsuno NH, Kitayama J, et al. Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis [J]. Angiogenesis, 2006, 9(2): 83-91.
    • (2006) Angiogenesis , vol.9 , Issue.2 , pp. 83-91
    • Asakage, M.1    Tsuno, N.H.2    Kitayama, J.3
  • 38
    • 33645472584 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention [J]
    • Bertl E, Bartsch H, Gerhäuser C. Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention [J]. Mol Cancer Ther, 2006, 5: 575-585.
    • (2006) Mol Cancer Ther , vol.5 , pp. 575-585
    • Bertl, E.1    Bartsch, H.2    Gerhäuser, C.3
  • 39
    • 29144494795 scopus 로고    scopus 로고
    • Enhanced sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to the combination of cisplatin and synthetic isothiocyanate ethyl 4-isothiocyanatobutanoate[J]
    • Bodo J, Chovancova J, Hunakova L, et al. Enhanced sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to the combination of cisplatin and synthetic isothiocyanate ethyl 4-isothiocyanatobutanoate[J]. Neoplasma, 2005, 52(6): 510-516.
    • (2005) Neoplasma , vol.52 , Issue.6 , pp. 510-516
    • Bodo, J.1    Chovancova, J.2    Hunakova, L.3
  • 40
    • 33749560635 scopus 로고    scopus 로고
    • Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate [J]
    • Wang LG, Liu XM, Chiao JW. Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate [J]. Carcinogenesis, 2006, 27: 2124-2132.
    • (2006) Carcinogenesis , vol.27 , pp. 2124-2132
    • Wang, L.G.1    Liu, X.M.2    Chiao, J.W.3
  • 41
    • 0036805387 scopus 로고    scopus 로고
    • Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine [J]
    • Kamath TA, Morris ME. Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine [J], Pharm Res, 2002, 19(10): 1509-15.
    • (2002) Pharm Res , vol.19 , Issue.10 , pp. 1509-1515
    • Kamath, T.A.1    Morris, M.E.2
  • 42
    • 3042552897 scopus 로고    scopus 로고
    • Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport [J]
    • Hu K, MorrisME. Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport [J]. Pharm Sci, 2004, 93(7): 1901-1911.
    • (2004) Pharm Sci , vol.93 , Issue.7 , pp. 1901-1911
    • Hu, K.1    MorrisME2
  • 43
    • 27144442001 scopus 로고    scopus 로고
    • Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein) [J]
    • Ji Y, Morris ME. Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein) [J]. Mol Pharm, 2005, 2(5): 414-419.
    • (2005) Mol Pharm , vol.2 , Issue.5 , pp. 414-419
    • Ji, Y.1    Morris, M.E.2
  • 44
    • 17644382339 scopus 로고    scopus 로고
    • Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport [J]
    • Ji Y, Morris ME. Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport [J]. Pharm Res, 2004, 21(12): 2261-2269.
    • (2004) Pharm Res , vol.21 , Issue.12 , pp. 2261-2269
    • Ji, Y.1    Morris, M.E.2
  • 45
    • 22144497802 scopus 로고    scopus 로고
    • Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein [J]
    • Y Ji, Morris ME. Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein [J]. Biochem Pharmacol, 2005, 70(4): 640-647.
    • (2005) Biochem Pharmacol , vol.70 , Issue.4 , pp. 640-647
    • Ji, Y.1    Morris, M.E.2
  • 46
    • 34247842805 scopus 로고    scopus 로고
    • Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation, signal transduction pathways, part C: Cell signaling in health and disease volume 1095 published December 2006,[J]
    • Fimognari C, Lenzi M, Sciuscio D, et al. Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation, signal transduction pathways, part C: cell signaling in health and disease volume 1095 published December 2006,[J], Ann NY Acad Sci, 2007, 1095: 62-69.
    • (2007) Ann NY Acad Sci , vol.1095 , pp. 62-69
    • Fimognari, C.1    Lenzi, M.2    Sciuscio, D.3
  • 47
    • 0141453198 scopus 로고    scopus 로고
    • Effect of naturally occurring isothiocyanates on the immune system [J]
    • Manesh C, Kuttan G. Effect of naturally occurring isothiocyanates on the immune system [J]. Immunopharmacol Immunotoxicol, 2003, 25(3): 451-459.
    • (2003) Immunopharmacol Immunotoxicol , vol.25 , Issue.3 , pp. 451-459
    • Manesh, C.1    Kuttan, G.2
  • 48
    • 33749013279 scopus 로고    scopus 로고
    • Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma [J]
    • Thejass P, Kuttan G. Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma [J]. Immunopharmacol Immunotoxicol, 2006, 28(3): 443-457.
    • (2006) Immunopharmacol Immunotoxicol , vol.28 , Issue.3 , pp. 443-457
    • Thejass, P.1    Kuttan, G.2
  • 49
    • 34548564432 scopus 로고    scopus 로고
    • Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL/6 mice by sulforaphane [J]
    • Thejass P; Kuttan G. Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL/6 mice by sulforaphane [J]. Immunopharmacol Immunotoxicol, 2007, 29(2): 173-186.
    • (2007) Immunopharmacol Immunotoxicol , vol.29 , Issue.2 , pp. 173-186
    • Thejass, P.1    Kuttan, G.2
  • 50
    • 18744400264 scopus 로고    scopus 로고
    • Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori [J]
    • Haristoy X, Fahey JW, Scholtus I, et al. Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori [J]. Planta Med, 2005, 71(4): 326-330.
    • (2005) Planta Med , vol.71 , Issue.4 , pp. 326-330
    • Haristoy, X.1    Fahey, J.W.2    Scholtus, I.3
  • 51
    • 0034606676 scopus 로고    scopus 로고
    • Fruit and vegetable intakes and prostate cancer risk [J]
    • Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes and prostate cancer risk [J]. Natl Cancer Inst, 2000; 92: 61-68.
    • (2000) Natl Cancer Inst , vol.92 , pp. 61-68
    • Cohen, J.H.1    Kristal, A.R.2    Stanford, J.L.3
  • 52
    • 34547795788 scopus 로고    scopus 로고
    • Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast [J]
    • Cornblatt BS, Ye LX, Dinkova- Kostova AT, et al. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast [J]. Carcinogenesis, 2007, 28: 1485-1490.
    • (2007) Carcinogenesis , vol.28 , pp. 1485-1490
    • Cornblatt, B.S.1    Ye, L.X.2    Dinkova- Kostova, A.T.3
  • 53
    • 0042674326 scopus 로고    scopus 로고
    • Isothiocyanate levels, brassica, and human breast cancer [J]
    • Fowke JH, Chung FL, Jin F, et al. Isothiocyanate levels, brassica, and human breast cancer [J]. Cancer Res, 2003, 63: 3980-3986.
    • (2003) Cancer Res , vol.63 , pp. 3980-3986
    • Fowke, J.H.1    Chung, F.L.2    Jin, F.3
  • 54
    • 40549137444 scopus 로고    scopus 로고
    • 105Val genetic polymorphism, and breast cancer risk [J]
    • 105Val genetic polymorphism, and breast cancer risk [J]. Clin Nutr, 2008, 87: 753-760.
    • (2008) Clin Nutr , vol.87 , pp. 753-760
    • Lee, S.A.1    Fowke, J.H.2    Lu, W.3
  • 55
    • 53349152035 scopus 로고    scopus 로고
    • Urinary total isothiocyanates and colorectal cancer: A prospective study of men in shanghai, China [J]
    • Moy KA, Yuan JM, Chung FL, et al. Urinary total isothiocyanates and colorectal cancer: a prospective study of men in shanghai, China [J]. Cancer Epidemiol Biomarkers Prev, 2008, 17: 1354-1359.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 1354-1359
    • Moy, K.A.1    Yuan, J.M.2    Chung, F.L.3
  • 56
    • 85193611131 scopus 로고    scopus 로고
    • The epigenetic effect of phenylhexyl isothiocyanate on histone acetylation in patients with acute leukemia and non-leukemic disorders [J]
    • Xiao LY, Ma XD, Huang YQ, et al. The epigenetic effect of phenylhexyl isothiocyanate on histone acetylation in patients with acute leukemia and non-leukemic disorders [J]. Blood (ASH Annual Meeting Abstracts), 2007, 110: 4145.
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110 , pp. 4145
    • Xiao, L.Y.1    Ma, X.D.2    Huang, Y.Q.3
  • 57
    • 0038544193 scopus 로고    scopus 로고
    • Current mechanistic approaches to the chemoprevention of cancer [J]
    • Steele VE. Current mechanistic approaches to the chemoprevention of cancer [J]. Biochem Mol Biol, 2003, 36(1): 78-81.
    • (2003) Biochem Mol Biol , vol.36 , Issue.1 , pp. 78-81
    • Steele, V.E.1
  • 59
    • 11844266916 scopus 로고    scopus 로고
    • Cancer prevention by natural compounds [J]
    • Tsuda H, Ohshima Y, Nomoto H, et al. Cancer prevention by natural compounds [J]. Drug Metab Pharmacokinet, 2004, 19(4): 245-263.
    • (2004) Drug Metab Pharmacokinet , vol.19 , Issue.4 , pp. 245-263
    • Tsuda, H.1    Ohshima, Y.2    Nomoto, H.3
  • 60
    • 33947680664 scopus 로고    scopus 로고
    • Natural dietary anti-cancer chemopreventive compounds: Redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells [J]
    • Nair S, Li W, Kong AN. Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells [J]. Acta Pharmacol Sin, 2007, 28(4): 459-472.
    • (2007) Acta Pharmacol Sin , vol.28 , Issue.4 , pp. 459-472
    • Nair, S.1    Li, W.2    Kong, A.N.3


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