Inhibition of lipopolysaccharide-induced cyclooxygenase-2 transcription by 6-(methylsulfinyl) hexyl isothiocyanate, a chemopreventive compound from Wasabia japonica (Miq.) Matsumura, in mouse macrophages

Biochemical Pharmacology

Volumn 70, Issue 12, 2005, Pages 1772-1784

  Uto, Takuhiro ^a   Fujii, Makoto ^a   Hou, De Xing ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

6 (Methylsulfinyl)hexyl isothiocyanate; Cyclooxygenase 2; Lipopolysaccharide; Macrophage; Mitogen activated protein kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (METHYLSULFINYL)HEXYLISOTHIOCYANIC ACID; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIINFLAMMATORY AGENT; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN DELTA; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOTHIOCYANIC ACID DERIVATIVE; JANUS KINASE; JANUS KINASE INHIBITOR; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DRUG POTENCY; ENZYME INHIBITION; ENZYME REGULATION; GENE CONSTRUCT; GENE EXPRESSION; GENETIC TRANSFECTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WASABI; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLOOXYGENASE 2; DINOPROSTONE; ISOTHIOCYANATES; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; PHOSPHORYLATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 27744433506     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.09.023     Document Type: Article

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