Application of molecular modeling for prediction of substrate specificity in cytochrome P450 1A2 mutants

Drug Metabolism and Disposition

Volumn 36, Issue 11, 2008, Pages 2371-2380

  Tu, Youbin ^a   Deshmukh, Rahul ^a,b   Sivaneri, Meena ^a   Szklarz, Grazyna D ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; ETHOXYRESORUFIN; METHOXYRESORUFIN; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ARTICLE; COMPUTER PREDICTION; COMPUTER SIMULATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; GEOMETRY; HUMAN; LINEAR REGRESSION ANALYSIS; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; WILD TYPE;

CATALYTIC DOMAIN; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PREDICTIVE VALUE OF TESTS; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 54349098233     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.022640     Document Type: Article

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