Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 β-lactamase with altered substrate specificity for aztreonam and ceftazidime

Journal of Biological Chemistry

Volumn 271, Issue 37, 1996, Pages 22538-22545

  Cantu III, Carlos ^a   Huang, Wanzhi ^a   Palzkill, Timothy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZTREONAM; BETA LACTAMASE; CEFTAZIDIME;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; DRUG SPECIFICITY; ENZYME ACTIVITY; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AZTREONAM; BETA-LACTAMASES; CEFTAZIDIME; CEPHALOSPORINS; HYDROLYSIS; KINETICS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MONOBACTAMS; MUTAGENESIS, SITE-DIRECTED; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0029829133     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.37.22538     Document Type: Article

References (31)

1. Knothe, H., Shah, P., Krcmery, V., Antal, M., and Mitsuhashi, S. (1983) Infection 11, 315-317
2. Du Bois, S. K., Marriott, M. S., and Amyes, S. G. B. (1995) J. Antimicrob. Chemother. 35, 7-22
3. Huletsky, A., Knox, J. R., and Levesque, R. C. (1993) J. Biol. Chem. 268, 3690-3697
4. Raquet, X., Lamotte-Brasseur, J., Fonze, E., Goussard, S., Courvalin, P., and Frere, J. M. (1994) J. Mol. Biol. 244, 625-639
5. Sowek, J. A., Singer, S. B., Ohringer, S., Malley, M. F., Dougherty, T. J., Gougoutas, J. Z., and Bush, K. (1991) Biochemistry 30, 3179-3188
6. Venkatachalam, K. V., Huang, W., LaRocco, M., and Palzkill, T. (1994) J. Biol. Chem. 269, 23444-23450
7. Palzkill, T., and Botstein, D. (1991) Methods 3, 155-164
8. Palzkill, T., and Botstein, D. (1992) J. Bacteriol. 174, 5237-5243
9. Palzkill, T., and Botstein, D. (1992) Proteins 14, 29-44
10. Palzkill, T., Le, Q.-Q., Venkatachalam, K. V., LaRocco, M., and Ocera, H. (1994) Mol. Microbiol. 12, 217-229
11. Strynadka, N. C. J., Adachi, H., Jensen, S. E., Johns, K., Sielecki, A., Betzel, C., Sutoh, K., and James, M. N. G. (1992) Nature 359, 700-705
12. Jelsch, C., Mourey, L., Masson, J.-M., and Samama, J.-P. (1993) Proteins 16, 364-383
13. Healey, W., Labgold, M., and Richards, J. (1989) Proteins 6, 275-283
14. Kunkel, T. A., Roberts, J. D., and Zakour, R. A. (1987) Methods Enzymol. 154, 367-382
15. Siegel, E. C., Wain, S. L., Meltzer, S. F., Binion, M. L., and Steinberg, J. L. (1982) Mutat. Res. 93, 25-33
16. Bullock, W. O., Fernandez, J. M., and Short, J. M. (1987) BioTechniques 5, 376-379
17. Petrosino, J. F., and Palzkill, T. (1996) J. Bacteriol. 178, 1821-1828
18. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
19. Sanger, T., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 5463-5467
20. Neu, H. C., and Heppel, L. A. (1965) J. Biol. Chem. 240, 3685-3692
21. Appelbaum, P. C., Spangler, S. K., Pankuch, G. A., Philippon, A., Jacobs, M. R., Shiman, R., Goldstein, E. J. C., and Citron, D. M. (1994) J. Antimicrob. Chemother. 33, 33-40
22. Bush, K., Freudenberger, J. S., and Sykes, R. B. (1982) Antimicrob. Agents Chemother. 22, 414-420
23. Bevington, P. R. (1969) Data Reduction and Error Analysis for the Physical Sciences, McGraw Hill, New York
24. Fersht, A. (1985) Enzyme Structure and Mechanism, W. H. Freeman and Co., New York
25. Oefner, C., D'Arcy, A., Daly, J. J., Gubernator, K., Heinze, I., Hubschwieler, C., and Winkler, F. K. (1990) Nature 343, 284-288
26. Ambler, R. P., Coulson, F. W., Frere, J.-M., Ghuysen, J.-M., Joris, B., Forsman, M., Levesque, R. C., Tiraby, G., and Waley, S. G. (1991) Biochem. J. 276, 269-272
27. Carter, P. J., Winter, G., Wilkinson, A. J., and Fersht, A. R. (1984) Cell 38, 835-840
28. Wells, J. A. (1990) Biochemistry 29, 8509-8517
29. LiCata, V. J., and Ackers, G. K. (1995) Biochemistry 34, 3133-3139
30. Kuzin, A. P., Liu, H., Kelly, J. A., and Knox, J. R. (1995) Biochemistry 34, 9532-9540
31. Saves, I., Burlet-Schiltz, O., Maveyraud, L., Samama, J.-P., Prome, J.-C., and Masson, J.-M. (1995) Biochemistry 34, 11660-11667