Redirecting NK cells mediated tumor cell lysis by a new recombinant bifunctional protein

Protein Engineering, Design and Selection

Volumn 21, Issue 11, 2008, Pages 665-672

  Germain, Claire ^a,c   Campigna, Emmanuelle ^a   Salhi, Imed ^a   Morisseau, Sébastien ^a   Navarro Teulon, Isabelle ^a   Mach, Jean Pierre ^b   Pèlegrin, André ^a   Robert, Bruno ^a  

^a INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

'knob into hole' strategy; Bifunctional proteins; Natural killer cells; NKG2D; Tumor targeting

Indexed keywords

CHEMICAL ACTIVATION; CYTOLOGY; KNOBS; LIGANDS; PROTEINS; TUMORS;

'KNOB INTO HOLE' STRATEGY; BIFUNCTIONAL PROTEINS; NATURAL KILLER CELLS; NKG2D; TUMOR TARGETING;

CELLS;

CARCINOEMBRYONIC ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; LECTIN RECEPTOR; RECOMBINANT PROTEIN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL STIMULATION; CYTOLYSIS; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNOSURVEILLANCE; INNATE IMMUNITY; MOUSE; MUTAGENESIS; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN VARIANT; TUMOR CELL;

ANIMALS; BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, LYMPHOKINE-ACTIVATED; KILLER CELLS, NATURAL; MICE; MINOR HISTOCOMPATIBILITY ANTIGENS; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

MURINAE;

EID: 54249090686     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzn047     Document Type: Article

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