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Volumn 22, Issue 6, 1999, Pages 514-524

Bispecific antibodies in cancer therapy, from the laboratory to the clinic

Author keywords

Animal models; Bispecific monoclonal antibodies; Clinical studies; Review

Indexed keywords

BISPECIFIC ANTIBODY; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

EID: 0032700376     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/00002371-199911000-00006     Document Type: Article
Times cited : (22)

References (109)
  • 1
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-7.
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 2
    • 0024848965 scopus 로고
    • Monoclonal antibodies in cancer therapy
    • Mellstedt H. Monoclonal antibodies in cancer therapy. Curr Opin Immunol 1990;2:708-13.
    • (1990) Curr Opin Immunol , vol.2 , pp. 708-713
    • Mellstedt, H.1
  • 4
    • 0026712850 scopus 로고
    • Monoclonal antibody-based therapies of leukemia and lymphoma
    • Grossbard ML, Press OW, Appelbaum FR, et al. Monoclonal antibody-based therapies of leukemia and lymphoma. Blood 1992;80:863-78.
    • (1992) Blood , vol.80 , pp. 863-878
    • Grossbard, M.L.1    Press, O.W.2    Appelbaum, F.R.3
  • 5
    • 0029329572 scopus 로고
    • Targeted therapy for hematologic malignancies: Has its promise been realized?
    • Matthews DC, Appelbaum FR, Press OW, et al. Targeted therapy for hematologic malignancies: has its promise been realized? Curr Opin Hematol 1995;2:235-9.
    • (1995) Curr Opin Hematol , vol.2 , pp. 235-239
    • Matthews, D.C.1    Appelbaum, F.R.2    Press, O.W.3
  • 6
    • 0024826387 scopus 로고
    • Rational use of biological response modifiers in hematological malignancies-a review of treatment with interferon, cytotoxic cells and antibodies
    • Janson CH, Tehrani M, Wigzell H, et al. Rational use of biological response modifiers in hematological malignancies-a review of treatment with interferon, cytotoxic cells and antibodies. Leuk Res 1989;13:1039-46.
    • (1989) Leuk Res , vol.13 , pp. 1039-1046
    • Janson, C.H.1    Tehrani, M.2    Wigzell, H.3
  • 7
    • 0028224082 scopus 로고
    • Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes’ C colorectal carcinoma
    • Riethmüller G, Schneider-Gädicke E, Schlimok G, et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes’ C colorectal carcinoma. Lancet 1994;343:1177-83.
    • (1994) Lancet , vol.343 , pp. 1177-1183
    • Riethmüller, G.1    Schneider-Gädicke, E.2    Schlimok, G.3
  • 9
    • 0029898496 scopus 로고    scopus 로고
    • Expression of CD46, CD55, and CD59 on renal tumor cell lines and their role in preventing complement-mediated tumor cell lysis
    • Gorter A, Blok VT, Haasnoot WH, et al. Expression of CD46, CD55, and CD59 on renal tumor cell lines and their role in preventing complement-mediated tumor cell lysis. Lab Invest 1996;74:1039-49.
    • (1996) Lab Invest , vol.74 , pp. 1039-1049
    • Gorter, A.1    Blok, V.T.2    Haasnoot, W.H.3
  • 10
    • 0004673890 scopus 로고
    • Anti-murine response to mouse monoclonal antibodies: Clinical findings and implications
    • Reynolds JC, Del Vecchio S, Sakahara H. Anti-murine response to mouse monoclonal antibodies: clinical findings and implications. Nucl Med Biol 1989;16:121-5.
    • (1989) Nucl Med Biol , vol.16 , pp. 121-125
    • Reynolds, J.C.1    Del Vecchio, S.2    Sakahara, H.3
  • 11
    • 45349111034 scopus 로고
    • A simple qualitative determination of human antibodies to murine immunoglobulins (HAMA) in serum samples
    • Seccamani E, Tattanelli M, Mariani M. A simple qualitative determination of human antibodies to murine immunoglobulins (HAMA) in serum samples. Nucl Med Biol 1989;16:167-70.
    • (1989) Nucl Med Biol , vol.16 , pp. 167-170
    • Seccamani, E.1    Tattanelli, M.2    Mariani, M.3
  • 12
    • 0028947838 scopus 로고
    • Inhibition of bispecific monoclonal antibody (bsAb)-targeted cytolysis by human anti-mouse antibodies in ovarian carcinoma patients treated with bsAb-targeted activated T-lymphocytes
    • Lamers CHJ, Gratama JW, Wamaar SO, et al. Inhibition of bispecific monoclonal antibody (bsAb)-targeted cytolysis by human anti-mouse antibodies in ovarian carcinoma patients treated with bsAb-targeted activated T-lymphocytes. Int J Cancer 1995;60: 450-7.
    • (1995) Int J Cancer , vol.60 , pp. 450-457
    • Lamers, C.H.J.1    Gratama, J.W.2    Wamaar, S.O.3
  • 13
    • 0024040626 scopus 로고
    • Biological activity of human-mouse IgGl, IgG3 and IgG4 chimeric monoclonal antibodies with antitumor specificity
    • Steplewski Z, Sun LK, Shearman CW, et al. Biological activity of human-mouse IgGl, IgG3 and IgG4 chimeric monoclonal antibodies with antitumor specificity. Proc Natl Acad Sei USA 1988; 85:4852-6.
    • (1988) Proc Natl Acad Sei USA , vol.85 , pp. 4852-4856
    • Steplewski, Z.1    Sun, L.K.2    Shearman, C.W.3
  • 14
  • 15
    • 0024519173 scopus 로고
    • Induction of tumor-cell lysis by bi-specific monoclonal antibodies recognizing renal-cell carcinoma and CD3 antigen
    • Van Dijk J, Warnaar SO, van Eendenburg JDH, et al. Induction of tumor-cell lysis by bi-specific monoclonal antibodies recognizing renal-cell carcinoma and CD3 antigen. Int J Cancer 1989; 43:344-9.
    • (1989) Int J Cancer , vol.43 , pp. 344-349
    • Van Dijk, J.1    Warnaar, S.O.2    van Eendenburg, J.D.H.3
  • 16
    • 0027291202 scopus 로고
    • Analysis of production, purification, and cytolytic potential of bi-specific antibodies reactive with ovarian-carcinoma-associated antigens and the T-cell antigen CD3
    • Van Ravenswaay Claasen HH, Van de Griend RJ, Mezzanzanica D, et al. Analysis of production, purification, and cytolytic potential of bi-specific antibodies reactive with ovarian-carcinoma-associated antigens and the T-cell antigen CD3. Int J Cancer 1993;55:128-36.
    • (1993) Int J Cancer , vol.55 , pp. 128-136
    • Van Ravenswaay Claasen, H.H.1    Van de Griend, R.J.2    Mezzanzanica, D.3
  • 17
    • 0030772184 scopus 로고    scopus 로고
    • Construction and biological activity of a recombinant bispecific single-chain antibody designed for therapy of minimal residual colorectal cancer
    • Küfer P, Mack M, Gruber R, et al. Construction and biological activity of a recombinant bispecific single-chain antibody designed for therapy of minimal residual colorectal cancer. Cancer Immunol Immunother 1997;45:193-7.
    • (1997) Cancer Immunol Immunother , vol.45 , pp. 193-197
    • Küfer, P.1    Mack, M.2    Gruber, R.3
  • 18
    • 0028989967 scopus 로고
    • Tumor heterogeneity and immunotherapy of cancer
    • Fleuren GJ, Gorter A, Kuppen PJK, et al. Tumor heterogeneity and immunotherapy of cancer. Immunol Rev 1995;145:91-122.
    • (1995) Immunol Rev , vol.145 , pp. 91-122
    • Fleuren, G.J.1    Gorter, A.2    Kuppen, P.J.K.3
  • 19
    • 0026178662 scopus 로고
    • Tumor cell surface determinants in host immunity against metastases
    • Eisenbach L, Feldman M. Tumor cell surface determinants in host immunity against metastases. Cancer Biol 1991;2:179-88.
    • (1991) Cancer Biol , vol.2 , pp. 179-188
    • Eisenbach, L.1    Feldman, M.2
  • 20
    • 0028123273 scopus 로고
    • The expression of histocompatibility leukocyte antigens in the pathway to cervical carcinoma
    • Hilders CGJM, Houbiers JGA, Krul EJT, et al. The expression of histocompatibility leukocyte antigens in the pathway to cervical carcinoma. Am J Clin Pathol 1994;101:5-12.
    • (1994) Am J Clin Pathol , vol.101 , pp. 5-12
    • Hilders, C.G.J.M.1    Houbiers, J.G.A.2    Krul, E.J.T.3
  • 21
    • 0026623332 scopus 로고
    • MHC loss in colorectal tumours: Evidence for immunoselection
    • Kaklamanis L, Hill A. MHC loss in colorectal tumours: evidence for immunoselection. Cancer Surv 1995;13:155-71.
    • (1995) Cancer Surv , vol.13 , pp. 155-171
    • Kaklamanis, L.1    Hill, A.2
  • 22
    • 0001303221 scopus 로고
    • Recombination of a mixture of univalent antibody fragments of different specificity
    • Nisonoff A, Rivers MM. Recombination of a mixture of univalent antibody fragments of different specificity. Arch Biochem Biophys 1961;93:460-2.
    • (1961) Arch Biochem Biophys , vol.93 , pp. 460-462
    • Nisonoff, A.1    Rivers, M.M.2
  • 23
    • 0014396319 scopus 로고
    • Use of hybrid antibody with anti-gammaG and anti-ferritin specificities in locating cell surface antigens by electron microscopy
    • Hämmerling U, Aoki T, de Harven E, et al. Use of hybrid antibody with anti-gammaG and anti-ferritin specificities in locating cell surface antigens by electron microscopy. J Exp Med 1968; 128:1461-73.
    • (1968) J Exp Med , vol.128 , pp. 1461-1473
    • Hämmerling, U.1    Aoki, T.2    de Harven, E.3
  • 24
    • 0021832361 scopus 로고
    • Hybrid antibodies can target sites for attack by T cells
    • Staerz UD, Kanagawa O, Bevan MJ. Hybrid antibodies can target sites for attack by T cells. Nature 1985;314:628-31.
    • (1985) Nature , vol.314 , pp. 628-631
    • Staerz, U.D.1    Kanagawa, O.2    Bevan, M.J.3
  • 25
    • 0025245732 scopus 로고
    • Regional and systemic distribution of anti-tumor x anti-CD3 heteroaggregate antibodies and cultured human peripheral blood lymphocytes in a human colon cancer xenograft
    • Nelson H, Ramsey PS, Kerr LA, et al. Regional and systemic distribution of anti-tumor x anti-CD3 heteroaggregate antibodies and cultured human peripheral blood lymphocytes in a human colon cancer xenograft. J Immunol 1990;145:3507-15.
    • (1990) J Immunol , vol.145 , pp. 3507-3515
    • Nelson, H.1    Ramsey, P.S.2    Kerr, L.A.3
  • 26
    • 0024853465 scopus 로고
    • Targeting and activation of cytotoxic lymphocytes
    • Segal DM, Snider DP. Targeting and activation of cytotoxic lymphocytes. Chem Immunol 1989;47:179-213.
    • (1989) Chem Immunol , vol.47 , pp. 179-213
    • Segal, D.M.1    Snider, D.P.2
  • 27
    • 0021860882 scopus 로고
    • Preparation of bispecific antibodies by chemical recombination of monoclonal immunoglobulin G1 fragments
    • Brennan M, Davison PF, Paulus H. Preparation of bispecific antibodies by chemical recombination of monoclonal immunoglobulin G1 fragments. Science 1985;229:81-3.
    • (1985) Science , vol.229 , pp. 81-83
    • Brennan, M.1    Davison, P.F.2    Paulus, H.3
  • 28
    • 0023616796 scopus 로고
    • 2 antibody containing thioether-linked Fab’gamma fragments
    • 2 antibody containing thioether-linked Fab’gamma fragments. J Immunol 1987;139: 2367-75.
    • (1987) J Immunol , vol.139 , pp. 2367-2375
    • Glennie, M.J.1    McBride, H.M.2    Worth, A.T.3
  • 29
    • 0020518331 scopus 로고
    • Hybrid hybridomas and their use in immunohistochemistry
    • Milstein C, Cuello AC. Hybrid hybridomas and their use in immunohistochemistry. Nature 1983;305:537-40.
    • (1983) Nature , vol.305 , pp. 537-540
    • Milstein, C.1    Cuello, A.C.2
  • 30
    • 0022508883 scopus 로고
    • Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity
    • Staerz UD, Bevan MJ. Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity. Proc Natl Acad Sei USA 1986;83:1453-7.
    • (1986) Proc Natl Acad Sei USA , vol.83 , pp. 1453-1457
    • Staerz, U.D.1    Bevan, M.J.2
  • 31
    • 0000265925 scopus 로고
    • Hybrid hybridomas and the production of bi-specific monoclonal antibodies
    • Milstein C, Cuello AC. Hybrid hybridomas and the production of bi-specific monoclonal antibodies. Immunol Today 1984;5:299-304.
    • (1984) Immunol Today , vol.5 , pp. 299-304
    • Milstein, C.1    Cuello, A.C.2
  • 32
    • 0027238861 scopus 로고
    • The development and purification of a bispecific antibody for lymphokine-activated killer cell targeting against the rat colon carcinoma CC531
    • Kuppen PJK, Eggermont AMM, Smits KM, et al. The development and purification of a bispecific antibody for lymphokine-activated killer cell targeting against the rat colon carcinoma CC531. Cancer Immunol Immunother 1993;36:403-8.
    • (1993) Cancer Immunol Immunother , vol.36 , pp. 403-408
    • Kuppen, P.J.K.1    Eggermont, A.M.M.2    Smits, K.M.3
  • 33
    • 0026567963 scopus 로고
    • Formation of a bispecific antibody by the use of leucine zippers
    • Kostelny SA, Cole MS, Tso JY. Formation of a bispecific antibody by the use of leucine zippers. J Immunol 1992;148:1547-53.
    • (1992) J Immunol , vol.148 , pp. 1547-1553
    • Kostelny, S.A.1    Cole, M.S.2    Tso, J.Y.3
  • 34
    • 0024384644 scopus 로고
    • Preferential heterodimer formation by isolated leucine zippers from Fos and Jun
    • O’Shea EK, Rutkowski R, Stafford W, et al. Preferential heterodimer formation by isolated leucine zippers from Fos and Jun. Science 1989;245:646.
    • (1989) Science , vol.245 , pp. 646
    • O’Shea, E.K.1    Rutkowski, R.2    Stafford, W.3
  • 36
    • 0029069430 scopus 로고
    • Retargeting of CTL by an efficiently refolded bispecific single-chain Fv dimer produced in bacteria
    • Kurucz I, Titus JA, Jost CR, et al. Retargeting of CTL by an efficiently refolded bispecific single-chain Fv dimer produced in bacteria. J Immunol 1995;154:4576-82.
    • (1995) J Immunol , vol.154 , pp. 4576-4582
    • Kurucz, I.1    Titus, J.A.2    Jost, C.R.3
  • 37
    • 0031569465 scopus 로고    scopus 로고
    • Biologic properties of a bispecific single-chain antibody directed against 17-1A (Ep-CAM) and CD3: Tumor cell-dependent T cell stimulation and cytotoxic activity
    • Mack M, Gruber R, Schmidt S, et al. Biologic properties of a bispecific single-chain antibody directed against 17-1A (Ep-CAM) and CD3: tumor cell-dependent T cell stimulation and cytotoxic activity. J Immunol 1997;158:3965-70.
    • (1997) J Immunol , vol.158 , pp. 3965-3970
    • Mack, M.1    Gruber, R.2    Schmidt, S.3
  • 38
    • 0030810023 scopus 로고    scopus 로고
    • Diabodies: Small bispecific antibody fragments
    • Holliger P, Winter G. Diabodies: small bispecific antibody fragments. Cancer Immunol Immunother 1997;45:128-30.
    • (1997) Cancer Immunol Immunother , vol.45 , pp. 128-130
    • Holliger, P.1    Winter, G.2
  • 39
    • 0027197493 scopus 로고
    • “Diabodies”: Small bivalent and bispecific antibody fragments
    • Holliger P, Prospero T, Winter G. “Diabodies”: small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 1993; 90:6444-8.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6444-6448
    • Holliger, P.1    Prospero, T.2    Winter, G.3
  • 40
    • 0022884746 scopus 로고
    • Use of anti-receptor antibodies to focus T-cell activity
    • Staerz UD, Bevan MJ. Use of anti-receptor antibodies to focus T-cell activity. Immunol Today 1986;7:241-5.
    • (1986) Immunol Today , vol.7 , pp. 241-245
    • Staerz, U.D.1    Bevan, M.J.2
  • 41
    • 0021997079 scopus 로고
    • Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody
    • Perez P, Hoffman RW, Shaw S, et al. Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody. Nature 1985;316:354-6.
    • (1985) Nature , vol.316 , pp. 354-356
    • Perez, P.1    Hoffman, R.W.2    Shaw, S.3
  • 42
    • 0024442150 scopus 로고
    • Bispecific antibodies reactive with the multidrug-resistance-related glycoprotein and CD3 induce lysis of multidrug-resistant tumor cells
    • Van Dijk J, Tsuruo T, Segal DM, et al. Bispecific antibodies reactive with the multidrug-resistance-related glycoprotein and CD3 induce lysis of multidrug-resistant tumor cells. Int J Cancer 1989;44:738-43.
    • (1989) Int J Cancer , vol.44 , pp. 738-743
    • Van Dijk, J.1    Tsuruo, T.2    Segal, D.M.3
  • 43
    • 0027192881 scopus 로고
    • T-cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model: III. Activation of resting T cells and tumor neutralization induced by bispecific antibodies
    • Beun GDM, Van de Velde CJH, Fleuren GJ. T-cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model: III. Activation of resting T cells and tumor neutralization induced by bispecific antibodies. J Immunother 1993;13:223-31.
    • (1993) J Immunother , vol.13 , pp. 223-231
    • Beun, G.D.M.1    Van de Velde, C.J.H.2    Fleuren, G.J.3
  • 44
    • 0025912699 scopus 로고
    • Localization of monoclonal antibody G250 and bispecific monoclonal antibody CD3/ G250 in human renal-cell carcinoma xenografts’, relative effects of size and affinity
    • Van Dijk J, Zegveld ST, Fleuren GJ, et al. Localization of monoclonal antibody G250 and bispecific monoclonal antibody CD3/ G250 in human renal-cell carcinoma xenografts’, relative effects of size and affinity. Int J Cancer 1991;48:738-43.
    • (1991) Int J Cancer , vol.48 , pp. 738-743
    • Van Dijk, J.1    Zegveld, S.T.2    Fleuren, G.J.3
  • 45
    • 0023126589 scopus 로고
    • The use of hybrid hybridomas to target human cytotoxic T lymphocytes
    • Lanzavecchia A, Scheidegger D. The use of hybrid hybridomas to target human cytotoxic T lymphocytes. Eur J Immunol 1987;17: 105-11.
    • (1987) Eur J Immunol , vol.17 , pp. 105-111
    • Lanzavecchia, A.1    Scheidegger, D.2
  • 46
    • 0023629058 scopus 로고
    • Human K/natural killer cells targeted with hetero-cross-linked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo
    • Titus JA, Perez P, Kaubisch A, et al. Human K/natural killer cells targeted with hetero-cross-linked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo. J Immunol 1987;139:3153-8.
    • (1987) J Immunol , vol.139 , pp. 3153-3158
    • Titus, J.A.1    Perez, P.2    Kaubisch, A.3
  • 47
    • 0024272524 scopus 로고
    • Effect of combined therapy with lymphokine-activated killer cells, interleukin 2 and specific monoclonal antibody on established B16 melanoma lung metastases
    • Eisenthal A, Cameron RB, Uppenkamp I, et al. Effect of combined therapy with lymphokine-activated killer cells, interleukin 2 and specific monoclonal antibody on established B16 melanoma lung metastases. Cancer Res 1988;48:7140-5.
    • (1988) Cancer Res , vol.48 , pp. 7140-7145
    • Eisenthal, A.1    Cameron, R.B.2    Uppenkamp, I.3
  • 48
    • 0021751543 scopus 로고
    • Production of target-specific effector cells using hetero-cross-linked aggregates containing anti-target and anti-Fcgamma receptor antibodies
    • Karpovsky B, Titus JA, Stephany DA, et al. Production of target-specific effector cells using hetero-cross-linked aggregates containing anti-target and anti-Fcgamma receptor antibodies. J Exp Med 1987;160:1686-701.
    • (1987) J Exp Med , vol.160 , pp. 1686-1701
    • Karpovsky, B.1    Titus, J.A.2    Stephany, D.A.3
  • 49
    • 0026469479 scopus 로고
    • Targeting of T or NK lymphocytes against tumor cells by bispecific monoclonal antibodies: Role of different triggering molecules
    • Ferrini S, Cambiaggi A, Cantoni C, et al. Targeting of T or NK lymphocytes against tumor cells by bispecific monoclonal antibodies: role of different triggering molecules. Int J Cancer 1992; 52(suppl 7):15-8.
    • (1992) Int J Cancer , vol.52 , pp. 15-18
    • Ferrini, S.1    Cambiaggi, A.2    Cantoni, C.3
  • 50
    • 0030042385 scopus 로고    scopus 로고
    • Inhibitory MHC class I receptors on NK cells and T cells
    • Lanier LL, Phillips JH. Inhibitory MHC class I receptors on NK cells and T cells. Immunol Today 1996;17:86-91.
    • (1996) Immunol Today , vol.17 , pp. 86-91
    • Lanier, L.L.1    Phillips, J.H.2
  • 51
    • 0031046201 scopus 로고    scopus 로고
    • Killer cell inhibitory receptors: Diversity, specificity, and function
    • Long EO, Burshtyn DN, Clark WP, et al. Killer cell inhibitory receptors: diversity, specificity, and function. Immunol Rev 1997; 155:135-44.
    • (1997) Immunol Rev , vol.155 , pp. 135-144
    • Long, E.O.1    Burshtyn, D.N.2    Clark, W.P.3
  • 52
    • 85045589345 scopus 로고    scopus 로고
    • Function and specificity of human natural killer cell receptors
    • Moretta A, Parolini S, Castriconi R, et al. Function and specificity of human natural killer cell receptors. Eur J Immunogenet 1997; 24:457-68.
    • (1997) Eur J Immunogenet , vol.24 , pp. 457-468
    • Moretta, A.1    Parolini, S.2    Castriconi, R.3
  • 53
    • 0027245530 scopus 로고
    • T cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. II. Syngeneic colon carcinoma CC531 is efficiently killed by retargeted cytotoxic T-lymphocytes in vitro despite limited lysis in 51-Cr release assays
    • Beun GDM, Gorter A, Nooyen Y, et al. T cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. II. Syngeneic colon carcinoma CC531 is efficiently killed by retargeted cytotoxic T-lymphocytes in vitro despite limited lysis in 51-Cr release assays. J Immunol 1993;150:2305-15.
    • (1993) J Immunol , vol.150 , pp. 2305-2315
    • Beun, G.D.M.1    Gorter, A.2    Nooyen, Y.3
  • 54
    • 0027268236 scopus 로고
    • T cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. IV. Tumor neutralization in Winn type assays
    • Beun GDM, Van de Velde CJH, Fleuren GJ, et al. T cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. IV. Tumor neutralization in Winn type assays. J Immunother 1993;14:11-5.
    • (1993) J Immunother , vol.14 , pp. 11-15
    • Beun, G.D.M.1    Van de Velde, C.J.H.2    Fleuren, G.J.3
  • 56
    • 0025348891 scopus 로고
    • Targeting of human T-lymphocytes with bispecific antibodies to react against human ovarian carcinoma cells growing in nu/nu mice
    • Garrido MA, Valdayo MJ, Winkler DF, et al. Targeting of human T-lymphocytes with bispecific antibodies to react against human ovarian carcinoma cells growing in nu/nu mice. Cancer Res 1990; 50:4227-32.
    • (1990) Cancer Res , vol.50 , pp. 4227-4232
    • Garrido, M.A.1    Valdayo, M.J.2    Winkler, D.F.3
  • 57
    • 0028158120 scopus 로고
    • Immunotherapy in a human ovarian cancer xenograft model with two bispecific monoclonal antibodies: OV-TL 3/CD3 and OC™R
    • Van Ravenswaay Claasen HH, Eggermont AMM, Nooyen YA, et al. Immunotherapy in a human ovarian cancer xenograft model with two bispecific monoclonal antibodies: OV-TL 3/CD3 and OC™R. Gynecol Oncol 1994;52:199-206.
    • (1994) Gynecol Oncol , vol.52 , pp. 199-206
    • Van Ravenswaay Claasen, H.H.1    Eggermont, A.M.M.2    Nooyen, Y.A.3
  • 58
    • 0026474226 scopus 로고
    • Bispecific IgG and IL-2 therapy of a syngeneic B-cell lymphoma in immunocompetent mice
    • Weiner GJ. Bispecific IgG and IL-2 therapy of a syngeneic B-cell lymphoma in immunocompetent mice. Int J Cancer 1992; 52(suppl 7):63-6.
    • (1992) Int J Cancer , vol.52 , pp. 63-66
    • Weiner, G.J.1
  • 59
    • 0026489047 scopus 로고
    • Bispecific antibody therapy of two murine B-cell lymphomas
    • Demanet C, Brissinck J, Moser M, et al. Bispecific antibody therapy of two murine B-cell lymphomas. Int J Cancer 1992;52(suppl 7):67-8.
    • (1992) Int J Cancer , vol.52 , pp. 67-68
    • Demanet, C.1    Brissinck, J.2    Moser, M.3
  • 60
    • 0027506272 scopus 로고
    • Inhibition of human colon cancer growth by antibody-directed human LAK cells in SCID mice
    • Takahashi H, Nakada T, Puisieux I. Inhibition of human colon cancer growth by antibody-directed human LAK cells in SCID mice. Science 1993;259:1460-3.
    • (1993) Science , vol.259 , pp. 1460-1463
    • Takahashi, H.1    Nakada, T.2    Puisieux, I.3
  • 61
    • 0025351406 scopus 로고
    • Role of the CD28 receptor in T-cell activation
    • June CH, Ledbetter JA, Linsley PS, et al. Role of the CD28 receptor in T-cell activation. Immunol Today 1990;11:211-6.
    • (1990) Immunol Today , vol.11 , pp. 211-216
    • June, C.H.1    Ledbetter, J.A.2    Linsley, P.S.3
  • 62
    • 0026537347 scopus 로고
    • CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
    • Harding FA, McArthur JG, Gross JA, et al. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992;356:607-9.
    • (1992) Nature , vol.356 , pp. 607-609
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3
  • 63
    • 0028862810 scopus 로고
    • Treatment of heterotransplanted Hodgkin’s tumors in SCID mice by a combination of human NK orT cells and bispecific antibodies
    • Renner C, Pfreundschuh M. Treatment of heterotransplanted Hodgkin’s tumors in SCID mice by a combination of human NK orT cells and bispecific antibodies. J Hematother 1995;4:447-51.
    • (1995) J Hematother , vol.4 , pp. 447-451
    • Renner, C.1    Pfreundschuh, M.2
  • 64
    • 0030007378 scopus 로고
    • Cure of disseminated xenografted human Hodgkin’s tumors by bispecific monoclonal antibodies and human T cells: The role of human T cell subsets in a preclinical model
    • Renner C, Bauer S, Sahin U, et al. Cure of disseminated xenografted human Hodgkin’s tumors by bispecific monoclonal antibodies and human T cells: the role of human T cell subsets in a preclinical model. Blood 1995;87:2930-7.
    • (1995) Blood , vol.87 , pp. 2930-2937
    • Renner, C.1    Bauer, S.2    Sahin, U.3
  • 65
    • 15644384495 scopus 로고    scopus 로고
    • Prevention of Epstein-Barr virus-induced human B-cell lymphoma in severe combined immunodeficient mice treated with CD3xCD19 bispecific antibodies, CD28 monospecific antibodies, and autologous T cells
    • Bohlen H, Manzke O, Titzer S, et al. Prevention of Epstein-Barr virus-induced human B-cell lymphoma in severe combined immunodeficient mice treated with CD3xCD19 bispecific antibodies, CD28 monospecific antibodies, and autologous T cells. Cancer Res 1997;57:1704-9.
    • (1997) Cancer Res , vol.57 , pp. 1704-1709
    • Bohlen, H.1    Manzke, O.2    Titzer, S.3
  • 66
    • 0030727184 scopus 로고    scopus 로고
    • T cell activation and retargeting using staphylococcal enterotoxin B and bispecific antibody: An effective in vivo antitumor strategy
    • Porter LE, Nelson H, Ethem Gecim I, et al. T cell activation and retargeting using staphylococcal enterotoxin B and bispecific antibody: an effective in vivo antitumor strategy. Cancer Immunol Immunother 1997;45:180-3.
    • (1997) Cancer Immunol Immunother , vol.45 , pp. 180-183
    • Porter, L.E.1    Nelson, H.2    Ethem Gecim, I.3
  • 67
    • 0025789752 scopus 로고
    • Treatment of mice bearing BCLj lymphoma with bispecific antibodies
    • Brissinck J, Demanet C, Moser M, et al. Treatment of mice bearing BCLj lymphoma with bispecific antibodies. J Immunol 1991; 147:4019-26.
    • (1991) J Immunol , vol.147 , pp. 4019-4026
    • Brissinck, J.1    Demanet, C.2    Moser, M.3
  • 68
    • 2642648679 scopus 로고    scopus 로고
    • Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration
    • Hagenaars M, Ensink NG, Koelemij R, et al. Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration. Int J Cancer 1998;75:233-8.
    • (1998) Int J Cancer , vol.75 , pp. 233-238
    • Hagenaars, M.1    Ensink, N.G.2    Koelemij, R.3
  • 69
    • 0028349554 scopus 로고
    • The infiltration of experimentally induced lung metastases of colon carcinoma CC531 by adoptively transferred interleukin-2-activated natural killer cells in Wag rats
    • Kuppen PJK, Basse PH, Goldfarb RH, et al. The infiltration of experimentally induced lung metastases of colon carcinoma CC531 by adoptively transferred interleukin-2-activated natural killer cells in Wag rats. Int J Cancer 1994;56:574-9.
    • (1994) Int J Cancer , vol.56 , pp. 574-579
    • Kuppen, P.J.K.1    Basse, P.H.2    Goldfarb, R.H.3
  • 70
    • 0027427657 scopus 로고
    • Local antitumour treatment in carcinoma patients with bispecific-monoclonal-antibody-redirected T cells
    • Kroesen BJ, Ter Haar A, Spakman H, et al. Local antitumour treatment in carcinoma patients with bispecific-monoclonal-antibody-redirected T cells. Cancer Immunol Immunother 1993; 37:400-7.
    • (1993) Cancer Immunol Immunother , vol.37 , pp. 400-407
    • Kroesen, B.J.1    Ter Haar, A.2    Spakman, H.3
  • 71
    • 0029117559 scopus 로고
    • Regression of advanced ovarian carcinoma by intraperitoneal treatment with autologous T lymphocytes retargeted by a bispecific monoclonal antibody
    • Canevari S, Stoter G, Arienti F, et al. Regression of advanced ovarian carcinoma by intraperitoneal treatment with autologous T lymphocytes retargeted by a bispecific monoclonal antibody. J Natl Cancer Inst 1995;87:1463-9.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1463-1469
    • Canevari, S.1    Stoter, G.2    Arienti, F.3
  • 72
    • 0026494425 scopus 로고
    • Adoptive immunotherapy of ovarian carcinoma with bs-MAb-targeted lymphocytes: A multicenter study
    • Bolhuis RLH, Lamers CHJ, Goey SH, et al. Adoptive immunotherapy of ovarian carcinoma with bs-MAb-targeted lymphocytes: a multicenter study. Int J Cancer 1992;52(suppl 7):78-81.
    • (1992) Int J Cancer , vol.52 , pp. 78-81
    • Bolhuis, R.L.H.1    Lamers, C.H.J.2    Goey, S.H.3
  • 74
    • 0026771528 scopus 로고
    • Optimization of culture conditions for activation and large-scale expansion of human T lymphocytes for bispecific antibody-directed cellular immunotherapy
    • Lamers CHJ, Van de Griend RJ, Braakman E, et al. Optimization of culture conditions for activation and large-scale expansion of human T lymphocytes for bispecific antibody-directed cellular immunotherapy. Int J Cancer 1992;51:973-9.
    • (1992) Int J Cancer , vol.51 , pp. 973-979
    • Lamers, C.H.J.1    Van de Griend, R.J.2    Braakman, E.3
  • 75
    • 0030829616 scopus 로고    scopus 로고
    • Approaches to implement bispecific antibody treatment of ovarian carcinoma
    • Canevari S, Mezzanzanica D, Mazzoni A, et al. Approaches to implement bispecific antibody treatment of ovarian carcinoma. Cancer Immunol Immunother 1997;45:187-9.
    • (1997) Cancer Immunol Immunother , vol.45 , pp. 187-189
    • Canevari, S.1    Mezzanzanica, D.2    Mazzoni, A.3
  • 76
    • 0030796406 scopus 로고    scopus 로고
    • Local but no systemic immunomodulation by intraperitoneal treatment of advanced ovarian cancer with autologous T lymphocytes re-targeted by a bi-specific monoclonal antibody
    • Lamers CHJ, Bolhuis RLH, Wamaar SO, et al. Local but no systemic immunomodulation by intraperitoneal treatment of advanced ovarian cancer with autologous T lymphocytes re-targeted by a bi-specific monoclonal antibody. Int J Cancer 1997;73: 211-9.
    • (1997) Int J Cancer , vol.73 , pp. 211-219
    • Lamers, C.H.J.1    Bolhuis, R.L.H.2    Wamaar, S.O.3
  • 77
    • 0025161953 scopus 로고
    • Preliminary trial of specific targeting therapy against malignant glioma
    • Nitta T, Sato K, Yagita H, et al. Preliminary trial of specific targeting therapy against malignant glioma. Lancet 1990;335: 368-71.
    • (1990) Lancet , vol.335 , pp. 368-371
    • Nitta, T.1    Sato, K.2    Yagita, H.3
  • 78
    • 0028883695 scopus 로고
    • Clinical development of 2B1, a bispecific murine monoclonal antibody targeting c-erbB-2 and FcgammaRIII
    • Weiner LM, Clark JI, Ring DB, et al. Clinical development of 2B1, a bispecific murine monoclonal antibody targeting c-erbB-2 and FcgammaRIII. J Hematother 1995;4:453-6.
    • (1995) J Hematother , vol.4 , pp. 453-456
    • Weiner, L.M.1    Clark, J.I.2    Ring, D.B.3
  • 79
    • 0028822836 scopus 로고
    • Phase I trial of 2B1, a bispecific monoclonal antibody targeting c erbB-2 and FcgammaRIII
    • Weiner LM, Clark JI, Davey M, et al. Phase I trial of 2B1, a bispecific monoclonal antibody targeting c erbB-2 and FcgammaRIII. Cancer Res 1995;55:4586-93.
    • (1995) Cancer Res , vol.55 , pp. 4586-4593
    • Weiner, L.M.1    Clark, J.I.2    Davey, M.3
  • 80
    • 0030974954 scopus 로고    scopus 로고
    • Treatment of refractory Hodgkin’s disease with an anti-CD16/CD30 bispecific antibody
    • Hartmann F, Renner C, Jung W, et al. Treatment of refractory Hodgkin’s disease with an anti-CD16/CD30 bispecific antibody. Blood 1997;89:2042-7.
    • (1997) Blood , vol.89 , pp. 2042-2047
    • Hartmann, F.1    Renner, C.2    Jung, W.3
  • 81
    • 0028122745 scopus 로고
    • Phase I study of intravenously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2
    • Kroesen BJ, Buter J, Sleijfer DT, et al. Phase I study of intravenously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2. Br J Cancer 1994;70:652-61.
    • (1994) Br J Cancer , vol.70 , pp. 652-661
    • Kroesen, B.J.1    Buter, J.2    Sleijfer, D.T.3
  • 82
    • 0028805090 scopus 로고
    • Clinical trials of bispecific antibody MDX-210 in women with advanced breast or ovarian cancer that overexpresses HER-2/neu
    • Valone FH, Kaufman PA, Guyre PM, et al. Clinical trials of bispecific antibody MDX-210 in women with advanced breast or ovarian cancer that overexpresses HER-2/neu. J Hematother 1995;4:471-5.
    • (1995) J Hematother , vol.4 , pp. 471-475
    • Valone, F.H.1    Kaufman, P.A.2    Guyre, P.M.3
  • 83
    • 0029095589 scopus 로고
    • Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu
    • Valone FH, Kaufman PA, Guyre PM, et al. Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu. J Clin Oncol 1995;13:2281-92.
    • (1995) J Clin Oncol , vol.13 , pp. 2281-2292
    • Valone, F.H.1    Kaufman, P.A.2    Guyre, P.M.3
  • 84
    • 0029062025 scopus 로고
    • CD8 T cell activation after intravenous administration of CD3 x CD19 bispecific antibody in patients with non-Hodgkin lymphoma
    • De Gast GC, Haagen I-A, Van Houten AA, et al. CD8 T cell activation after intravenous administration of CD3 x CD19 bispecific antibody in patients with non-Hodgkin lymphoma. Cancer Immunol Immunother 1995;40:390-6.
    • (1995) Cancer Immunol Immunother , vol.40 , pp. 390-396
    • De Gast, G.C.1    Haagen, I.-A.2    Van Houten, A.A.3
  • 85
    • 0344550232 scopus 로고
    • T cell activation by bispecific monoclonal antibodies for immunotherapy of cancer: Fundamental, practical and clinical applications
    • Romet-Lemonne JL, Fanger MW, Segal DM, eds, Les Ulis, France: Fondation Nationale de Transfusion Sanguine
    • Bolhuis RLH, Ronteltap CPM, Van Dijk J, Wamaar SO, Braakman E. T cell activation by bispecific monoclonal antibodies for immunotherapy of cancer: fundamental, practical and clinical applications. In: Romet-Lemonne JL, Fanger MW, Segal DM, eds. Bispecific antibodies and targeted cellular cytotoxicity. Les Ulis, France: Fondation Nationale de Transfusion Sanguine, 1990; 227-31.
    • (1990) Bispecific antibodies and targeted cellular cytotoxicity , pp. 227-231
    • Bolhuis, R.L.H.1    Ronteltap, C.P.M.2    Van Dijk, J.3    Wamaar, S.O.4    Braakman, E.5
  • 86
    • 0028204494 scopus 로고
    • New chimeric anti-pancarcinoma monoclonal antibody with superior cytotoxicity-mediating potency
    • Velders MP, Litvinov SV, Wamaar SO, et al. New chimeric anti-pancarcinoma monoclonal antibody with superior cytotoxicity-mediating potency. Cancer Res 1994;54:1753-9.
    • (1994) Cancer Res , vol.54 , pp. 1753-1759
    • Velders, M.P.1    Litvinov, S.V.2    Wamaar, S.O.3
  • 87
    • 0018756804 scopus 로고
    • Natural polyclonality of spontaneous AKR leukemia and its consequences for so-called specific immunotherapy
    • Ollson L, Ebbesen P. Natural polyclonality of spontaneous AKR leukemia and its consequences for so-called specific immunotherapy. J Natl Cancer Inst 1979;62:623-7.
    • (1979) J Natl Cancer Inst , vol.62 , pp. 623-627
    • Ollson, L.1    Ebbesen, P.2
  • 88
    • 0030007803 scopus 로고    scopus 로고
    • In vivo analysis of the ‘bystander effect’: A cytokine cascade
    • Ramesh R, Marrogi AJ, Munshi A, et al. In vivo analysis of the ‘bystander effect’: a cytokine cascade. Exp Hematol 1996;24: 829-38.
    • (1996) Exp Hematol , vol.24 , pp. 829-838
    • Ramesh, R.1    Marrogi, A.J.2    Munshi, A.3
  • 89
    • 0027137485 scopus 로고
    • Anti-transforming growth factor (TGF)-(3 antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-(3 interactions in human breast cancer progression
    • Arteaga CL, Hurd SD, Winnier AR, et al. Anti-transforming growth factor (TGF)-(3 antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-(3 interactions in human breast cancer progression. J Clin Invest 1993;92:2569-76.
    • (1993) J Clin Invest , vol.92 , pp. 2569-2576
    • Arteaga, C.L.1    Hurd, S.D.2    Winnier, A.R.3
  • 90
    • 0028221614 scopus 로고
    • Transforming growth factor: A matter of life and death
    • McCartney-Francis NL, Wahl SM. Transforming growth factor: a matter of life and death. J Leukocyte Biol 1994;55:401-9.
    • (1994) J Leukocyte Biol , vol.55 , pp. 401-409
    • McCartney-Francis, N.L.1    Wahl, S.M.2
  • 92
    • 0027336336 scopus 로고
    • 2-induced changes in the phenotype, morphology, and lytic activity of IL-2-activated natural killer cells
    • 2-induced changes in the phenotype, morphology, and lytic activity of IL-2-activated natural killer cells. J Immunol 1993;150:3747-54.
    • (1993) J Immunol , vol.150 , pp. 3747-3754
    • Linnemeyer, P.A.1    Pollack, S.B.2
  • 93
    • 0026753033 scopus 로고
    • Reversal of suppression of lymphokine-activated killer cells by transforming growth factor-3 in ovarian carcinoma ascitic fluid requires interleukin-2 combined with anti-CD3 antibody
    • Hirte HW, Clark DA, O’Neil G, et al. Reversal of suppression of lymphokine-activated killer cells by transforming growth factor-3 in ovarian carcinoma ascitic fluid requires interleukin-2 combined with anti-CD3 antibody. Cell Immunol 1992;142:207-16.
    • (1992) Cell Immunol , vol.142 , pp. 207-216
    • Hirte, H.W.1    Clark, D.A.2    O’Neil, G.3
  • 94
    • 0030031549 scopus 로고    scopus 로고
    • Interleukin-12 increases bispecific-antibody-mediated natural killer cell cytotoxicity against human tumors
    • Sahin U, Kraft-Bauer S, Ohnesorge S, et al. Interleukin-12 increases bispecific-antibody-mediated natural killer cell cytotoxicity against human tumors. Cancer Immunol Immunother 1996; 42:9-14.
    • (1996) Cancer Immunol Immunother , vol.42 , pp. 9-14
    • Sahin, U.1    Kraft-Bauer, S.2    Ohnesorge, S.3
  • 95
    • 0022478367 scopus 로고
    • Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor
    • Grabstein KH, Urdal DL, Tushinski RJ, et al. Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science 1986;232:506-8.
    • (1986) Science , vol.232 , pp. 506-508
    • Grabstein, K.H.1    Urdal, D.L.2    Tushinski, R.J.3
  • 96
    • 0024359707 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity
    • Masucci G, Wersall P, Ragnhammar P, et al. Granulocyte-macrophage colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity. Cancer Immunol Immunother 1989;29:288-92.
    • (1989) Cancer Immunol Immunother , vol.29 , pp. 288-292
    • Masucci, G.1    Wersall, P.2    Ragnhammar, P.3
  • 97
    • 0027460426 scopus 로고
    • Effect of monoclonal antibody 17-1A and GM-CSF in patients with advanced colorectal carcinoma-long-lasting, complete remissions can be induced
    • Ragnhammar P, Fagerberg J, Frödin J-E, et al. Effect of monoclonal antibody 17-1A and GM-CSF in patients with advanced colorectal carcinoma-long-lasting, complete remissions can be induced. Int J Cancer 1993;53:751-8.
    • (1993) Int J Cancer , vol.53 , pp. 751-758
    • Ragnhammar, P.1    Fagerberg, J.2    Frödin, J.-E.3
  • 98
    • 0031053094 scopus 로고    scopus 로고
    • Preclinical studies with Fc(gamma)R bispecific antibodies and granulocyte colony-stimulating factor-primed neutrophils as effector cells against HER-2/neu overexpressing breast cancer
    • Stockmeyer B, Valerius T, Repp R, et al. Preclinical studies with Fc(gamma)R bispecific antibodies and granulocyte colony-stimulating factor-primed neutrophils as effector cells against HER-2/neu overexpressing breast cancer. Cancer Res 1997;57: 696-701.
    • (1997) Cancer Res , vol.57 , pp. 696-701
    • Stockmeyer, B.1    Valerius, T.2    Repp, R.3
  • 99
    • 0028842806 scopus 로고
    • G-CSF-stimulated PMN in immunotherapy of breast cancer with a bispecific antibody to FcgammaRI and to HER-2/neu (MDX-210)
    • Repp R, Valerius T, Wieland G, et al. G-CSF-stimulated PMN in immunotherapy of breast cancer with a bispecific antibody to FcgammaRI and to HER-2/neu (MDX-210). J Hematother 1995; 4:415-21.
    • (1995) J Hematother , vol.4 , pp. 415-421
    • Repp, R.1    Valerius, T.2    Wieland, G.3
  • 100
    • 0030829805 scopus 로고    scopus 로고
    • Clinical evaluation of the bispecific antibody MDX-H210 (anti-FcgammaRI x anti-HER-2/neu) in combination with granulocyte-colony-stimulating factor (Filgrastim) for treatment of advanced breast cancer
    • van Ojik HH, Repp R, Groenewegen G, et al. Clinical evaluation of the bispecific antibody MDX-H210 (anti-FcgammaRI x anti-HER-2/neu) in combination with granulocyte-colony-stimulating factor (Filgrastim) for treatment of advanced breast cancer. Cancer Immunol Immunother 1997;45:207-9.
    • (1997) Cancer Immunol Immunother , vol.45 , pp. 207-209
    • van Ojik, H.H.1    Repp, R.2    Groenewegen, G.3
  • 101
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
    • Gross G, Waks T, Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci USA 1989;86: 10024-8.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 102
    • 0027303734 scopus 로고
    • New simplified molecular design for functional T cell receptor
    • Brocker T, Peter A, Traunecker A, et al. New simplified molecular design for functional T cell receptor. Eur J Immunol 1993;23: 1435-9.
    • (1993) Eur J Immunol , vol.23 , pp. 1435-1439
    • Brocker, T.1    Peter, A.2    Traunecker, A.3
  • 103
    • 0027501259 scopus 로고
    • Targeting of T-lymphocytes to Neu/HER-expressing ceils using chimeric single chain Fv receptors
    • Stancovski I, Schindler DG, Waks T, et al. Targeting of T-lymphocytes to Neu/HER-expressing ceils using chimeric single chain Fv receptors. J Immunol 1993;151:6577-82.
    • (1993) J Immunol , vol.151 , pp. 6577-6582
    • Stancovski, I.1    Schindler, D.G.2    Waks, T.3
  • 104
    • 0029948642 scopus 로고    scopus 로고
    • Cytolysis of tumor cells expressing the neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes
    • Altenschmidt U, Kahl R, Moritz D, et al. Cytolysis of tumor cells expressing the neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes. Clin Cancer Res 1996; 2:1001-8.
    • (1996) Clin Cancer Res , vol.2 , pp. 1001-1008
    • Altenschmidt, U.1    Kahl, R.2    Moritz, D.3
  • 105
    • 0028879071 scopus 로고
    • A spacer region between the single chain antibody and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity
    • Moritz D, Groner B. A spacer region between the single chain antibody and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity. Gene Ther 1995;2:539-46.
    • (1995) Gene Ther , vol.2 , pp. 539-546
    • Moritz, D.1    Groner, B.2
  • 106
    • 0025746633 scopus 로고
    • Bispecific anti-idiotype/anti-CD3 antibody therapy of murine B cell lymphoma
    • Weiner GJ, Hillstrom JR. Bispecific anti-idiotype/anti-CD3 antibody therapy of murine B cell lymphoma. J Immunol 1991; 147: 4035-44.
    • (1991) J Immunol , vol.147 , pp. 4035-4044
    • Weiner, G.J.1    Hillstrom, J.R.2
  • 107
    • 84920340040 scopus 로고
    • In vivo evaluation of the antitumor activity of hormone-antibody bifunctional conjugates plus human cytotoxic T lymphocytes
    • Romet-Lemonne JL, Fanger MW, Segal DM, eds, Les Ulis, France: Fondation Nationale de Transfusion Sanguine
    • Liu MA, Cho WS, Hawe LA, et al. In vivo evaluation of the antitumor activity of hormone-antibody bifunctional conjugates plus human cytotoxic T lymphocytes. In: Romet-Lemonne JL, Fanger MW, Segal DM, eds. Bispecific antibodies and targeted cellular cytotoxicity. Les Ulis, France: Fondation Nationale de Transfusion Sanguine, 1990:213-7.
    • (1990) Bispecific antibodies and targeted cellular cytotoxicity , pp. 213-217
    • Liu, M.A.1    Cho, W.S.2    Hawe, L.A.3
  • 108
    • 0029006241 scopus 로고
    • Reduction of EGP-2-positive pulmonary métastasés by bispecific-antibody-redirected T cells in an immunocompetent rat model
    • Kroesen BJ, Helfrich W, Bakker A, et al. Reduction of EGP-2-positive pulmonary métastasés by bispecific-antibody-redirected T cells in an immunocompetent rat model. Int J Cancer 1995;61: 812-8.
    • (1995) Int J Cancer , vol.61 , pp. 812-818
    • Kroesen, B.J.1    Helfrich, W.2    Bakker, A.3
  • 109
    • 84920341963 scopus 로고
    • Intrapleural and intraperitoneal application of bispecific antibody retargeted lymphocytes to cancer patients
    • Romet-Lemonne JL, Fanger MW, Segal DM, eds, Les Ulis, France: Fondation Nationale de Transfusion Sanguine
    • De Leij L, deJonge M, Terhaar A, et al. Intrapleural and intraperitoneal application of bispecific antibody retargeted lymphocytes to cancer patients. In: Romet-Lemonne JL, Fanger MW, Segal DM, eds. Bispecific antibodies and targeted cellular cytotoxicity. Les Ulis, France: Fondation Nationale de Transfusion Sanguine, 1990:249-53.
    • (1990) Bispecific antibodies and targeted cellular cytotoxicity , pp. 249-253
    • De Leij, L.1    deJonge, M.2    Terhaar, A.3


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