Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor

Blood

Volumn 92, Issue 10, 1998, Pages 3730-3736

  Liu, Hsin Ming ^b   Newbrough, Sally E ^b   Bhatia, Sudershan K ^b   Dahle, Christopher E ^b   Krieg, Arthur M ^b   Weiner, George J ^a  

^a UNIVERSITY OF IOWA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; IMMUNOGLOBULIN G2A; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OLIGODEOXYNUCLEOTIDE; VACCINE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER IMMUNIZATION; CPG ISLAND; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR; TUMOR GROWTH;

EID: 0032533269     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.10.3730     Document Type: Article

References (38)

1. Krieg AM, Vi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM: CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546, 1995
2. Pisetsky DS, Reich C, Crowley SD, Halpern MD: Immunological properties of bacterial DNA. Ann NY Acad Sci 772:152, 1995
3. Stacey JJ, Sweet MJ, Hume DA: Macrophages ingest and are activated by bacterial DNA. J Immunol 157:2116, 1996
4. Yamamoto S, Kuramoto E, Shimada T, Tokunaga T: In vitro augmentation of natural killer cell activity and production of interferon-alpha/beta and gamma with deoxyribonucleic acid fraction from mycobacterium bovis BCG. Jpn J Cancer Res 79:866, 1988
5. Yamamoto S, Yamamoto T, Shimada T, Kuramoto E, Yano O, Kataoka T, Tokunaga T: DNA from bacteria, but not vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microl Immunol 36:983, 1992
6. Messina JP, Gilkeson GS, Pisetsky DS: Simulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol 147: 1759, 1991
7. Cowdery JS, Chace JH, Yi AK, Krieg AM: Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J Immunol 156:4570, 1996
8. Halpern MD, Kurlander RJ, Pisetsky DS: Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cell Immunol 167:72, 1996
9. Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM: CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and Interferon gamma. Proc Natl Acad Sci USA 93:2879, 1996
10. Wooldridge JE, Bailas Z, Krieg AM, Weiner GJ: Immunostimulatory oligodoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood 89:2994, 1997
11. Weiner GJ, Liu HM, Wooldridge JE, Dahle CE, Krieg AM: Immunostimulatory oligodeuxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA 94:10833, 1997
12. Davis HL, Weeratna R, Waldschmidt TJ, Tygrett L, Schorr J, Krieg AM: CpG DNA is a potent adjuvant in mice immunized with recombinant hepatitis B surface antigen. J Immunol 160:870, 1998
13. Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV: Cpg oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Ex Med 186:1623, 1997
14. Leclerc C, Deriaud E, Rojas M, Whalen RG: The preferential induction of a Th1 immune response by DNA - Immunization is mediated by the immunostimulatory effect of DNA. Cell Immunol 179:97, 1997
15. Lipford GB, Bauer M, Blank C, Reiter R, Wagner H, Heeg K: CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen - A new class of vaccine adjuvants. Eur J Immunol 27:2340, 1997
16. Roman M, Martinorozco E, Goodman S, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E: Immunostimulatory DNA Sequences function as T helper-1-promoting adjuvants. Nat Med 3:849, 1997
17. Fagerberg J: Granulocyte-macrophage colony-stimulating factor as an adjuvant in tumor immunotherapy. Med Oncol 13:155, 1996
18. Tarr PE: Granulocyte-macrophage colony-stimulating factor and the immune system. Med Oncol 13:133, 1996
19. Jager E, Ringhoffer M, Dienes HP, Arand M, Karbach J, Jager D, Ilsemann C, Hagedorn M, Oesch F, Knuth A: Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptides in vivo. Int J Cancer 67:54, 1996
20. Kwak LW, Young HA, Pennington RW, Weeks SD: Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response. Proc Natl Acad Sci USA 93:10972, 1996
21. Tao MH, Levy R: Idiotype granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma, Nature 362:755, 1993
22. McLaughlin JP, Abrams S, Kantor J, Dobrzanski MJ, Green-baum J, Schlom J, Greiner JW: Immunization with a syngeneic tumor infected with vaccinia virus expressing granulocyte-macrophage colony-factor (GM-CSF) induces tumor regression and long-lasting immunity. J Immunother 20:449, 1997
23. Zitvogel L, Mayordomo JI, Tjandrawan T, DeLeo AB, Clarke MR, Lotze MT, Storkus WJ: Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines [see comments]. J Exp Med 183:87, 1996
24. Flamand V, Sornasse T, Thielemans K, Demanet C, Bakkus H, Bazin H, Tielernans F, Leo O, Urbain J, Moser M: Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur J Immunol 24:605, 1994
25. Timmerman J, Levy R: Enhanced immunogenicity of tumor-specific immunoglobulin-pulsed dendritic cells using a chimeric idiotype-GM-CSF fusion protein. Proc Am Assoc Cancer Res 38:616, 1997
26. Maloney DG, Kaminski MS, Burowski D, Haimovich J, Levy R: Monoclonal anti-idiotype antibodies against the murine B cell lymphoma 38C13: Characterization and use as probes for the biology of the tumor in vivo and in vitro. Hybridoma 4:191, 1986
27. Weiner GJ, Kaminski MS: Idiotype variants emerging after anti-idiotype monoclonal antibody therapy of a murine B cell lymphoma. J Immunol 142:343, 1989
28. Weiner GJ, Kaminski MS: Anti-idiotypic antibodies recognizing stable epitopes limit the emergence of idiotype variants in a murine B cell lymphoma. J Immunol 144:2436, 1990
29. Kaminski MS, Kitamura K, Maloney DG, Levy R: Idiotype vaccination against murine B cell lymphoma. Inhibition of tumor immunity by free idiotype protein. J Immunol 138:1289, 1987
30. Bergman Y, Haimovich J: Characterization of a carcinogen-induced murine B lymphocyte cell line of C3H/eB origin. Eur J Immunol 7:413, 1977
31. Eshhar Z, Blatt Y, Bergman Y, Haimovich J: Induction of Secretion of IgM from cells of the B cell line 38C13 by somatic hybridization. J Immunol 122:2430, 1979
32. Mayordomo JI, Zorina T, Storkus WJ, Zitvogel L, Celluzzi C, Falo LD, Melief CJ, Ildstad ST, Kast WM, Deleo AB, Lotze MT: Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat Med 1:1297, 1995
33. Yi AK, Chace JH, Cowdery JS, Krieg AM: IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNAand oligodeoxynucleotides. J Immunol 156:558, 1996
34. Krieg AM: Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA. Trends Microbiol 4:73, 1996
35. Stevens TL, Bossie A, Sanders VM, Femandez-Botran R, Coffman RL, Mosmann TR, Vitetta ES: Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334:255, 1988
36. Kaminski MS, Kitamura K, Maloney DG, Campbell MJ, Levy R: Importance of antibody isotype in monoclonal anti-idiotype therapy of a murine B cell lymphoma. A study of hybridoma class switch variants. J Immunol 136:1123, 1986
37. Lutz MB, Assmann CU, Girolomoni G, Ricciardi-Castagnoli P: Different cytokines regulate antigen uptake and presentation of a precursor dendritic cell line. Eur J Immunol 26:586, 1996
38. Kedar E, Palgi O, Golod G, Babai I, Barenholz Y: Delivery of cytokines by liposomes. III. Liposome-encapsulated GM-CSF and TNF-alpha show improved pharmacokinetics and biological activity and reduced toxicity in mice. J Immunother 20:180, 1997