Increased susceptibility to streptozotocin-induced β-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice

Molecular and Cellular Biology

Volumn 21, Issue 16, 2001, Pages 5605-5613

  Cardinal, J W ^a   Margison, G P ^a   Mynett, K J ^a   Yates, A P ^a   Cameron, D P ^a   Elder, R H ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA GLYCOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL DEATH; CONTROLLED STUDY; DIABETOGENESIS; DISEASE PREDISPOSITION; DNA REPAIR; DOSE RESPONSE; ENZYME ACTIVITY; EXCISION REPAIR; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FOLDING;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, TYPE 1; DNA GLYCOSYLASES; GENETIC PREDISPOSITION TO DISEASE; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; N-GLYCOSYL HYDROLASES; STREPTOZOCIN;

EID: 0034934716     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.16.5605-5613.2001     Document Type: Article

References (40)

1. Alkylation of DNA in rat tissues following administration of streptozotocin
2. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin
3. Poly(ADP-ribose) polymerase activation determines strain sensitivity to streptozotocin-induced β-cell death in inbred mice
4. Differential metabolite accumulation may be the cause of strain differences in sensitivity to streptozotocin-induced β-cell death in inbred mice
5. Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose) polymerase-1
6. Preventing insulin dependent diabetes mellitus: The environmental challenge
7. Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure
8. Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate
9. 4-ethenocytosine by lipid peroxidation products and nucleic acid bases
10. A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome
11. Role of nitric oxide in genotoxicity: Implications for carcinogenesis
12. Cyclosporin increases the rate and length of remisions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial
13. NF-κB to the rescue
14. The pancreatic islets in diabetes
15. Evidence for a direct action of exogenous insulin on the pancreatic islets of diabetic mice: Islet response to insulin preincubation
16. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
17. Antioxidants, NF-κB activation, and diabetogenesis
18. Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis
19. Defective maturation and function of antigen presenting cells in type 1 diabetes
20. Cell death, anatomical methods in cell death
21. The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system
22. Bovine serum albumin density gradient isolation of rat pancreatic islets
23. Methylation-induced blocks to in vitro DNA replication
24. Biological implications of the instability of the N-glycosidic bond of 3-methyldeoxyadenosine in DNA
25. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
26. Etheno adducts in spleen DNA of SJL mice stimulated to overproduce nitric oxide
27. Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model
28. Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
29. Nicotinamide prevents the development of diabetes in the cyclophosphamide-induced NOD mouse model by reducing beta-cell apoptosis
30. Molecular basis of experimental diabetes: Degeneration, oncogenesis and regeneration of pancreatic B-cells of islets of langerhans
31. Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly(ADP-ribose) polymerase-1 deficient mice
32. Early induction of diabetes in NOD mice by streptozotocin
33. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
34. Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signaling and reduces inflammatory cytokine production in aging
35. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus
36. Pancreatic islet cell tumors produced by the combined action of streptozotocin and nicotinamide
37. Mechanisms of carcinogenesis induced by alkylating agents
38. Poly(ADP-ribose) polymerase-1: What have we learned from the deficient mouse model?
39. DNA repair defect in poly(ADP-ribose)polymerase-deficient cell lines
40. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors