Differential regulation of Th1-type and Th2-type cytokine profiles in pancreatic islets of C57BL/6 and BALB/c mice by multiple low doses of streptozotocin

Immunobiology

Volumn 205, Issue 1, 2002, Pages 35-50

  Müller, Andreas ^a   Schott Ohly, Patricia ^a   Dohle, Claudia ^a   Gleichmann, Helga ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ALBUMIN; BETA ACTIN; CITRATE SODIUM; COLLAGENASE; CYTOKINE; FLUORESCEIN ISOTHIOCYANATE; FORMALDEHYDE; GLUCOSE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; MESSENGER RNA; MONOCLONAL ANTIBODY; PENICILLIN G; SAPONIN; SODIUM AZIDE; SODIUM DIHYDROGEN PHOSPHATE; SOLVENT; STREPTOMYCIN; STREPTOZOCIN; TAQ POLYMERASE; TRANSFORMING GROWTH FACTOR BETA1; TRYPSIN; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; DISEASE RESISTANCE; DRUG EFFECT; FEMALE; IMMUNOREGULATION; IN VITRO STUDY; INTERFERON PRODUCTION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; STREPTOZOCIN DIABETES; TH1 CELL; TH2 CELL;

EID: 0036203678     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-2985-00109     Document Type: Article

References (49)

1. Type-I Diabetes: A chronic autoimmune disease of human, mouse, and rat
2. Insulin-dependent diabetes mellitus
3. Prevention of type 1 diabetes
4. The role of helper T cell products in mouse B cell differentiation and isotype regulation
5. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalitis
6. Regulatory T cells and inflammatory bowel disease
7. The inhibitory effects of transforming growth factor β1 (TGF-β1) in autoimmune diseases
8. Heterogenity of helper/inducer T lymphocytes II. Effects of interleukin 4 and interleukin 2 producing T cell clones on resting B lymphocytes
9. Lymphokine-mediated regulation of the response of clones of T helper 1 and T helper 2 cells
10. Two types of mouse T helper cell: IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
11. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
12. Local expression of TNF-α in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
13. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice
14. + Th1 and Th2 cells derived from the spleens of diabetic NOD mice
15. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse
16. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
17. Cytokines and free radicals as effector molecules in the destruction of pancreatic β-cells
18. Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-γ, tumor necrosis factor, Lymphotoxin, and interleukin 1
19. TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype
20. Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
21. Multiple low-dose streptozotocin-induced hyperglycemia and insulitis C57B1/6 mice: Influence of inbred background, sex, and thymus
22. GLUT2 in pancreatic islets. Crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice
23. Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: Obligatory role of cell-mediated autoimmune processes
24. Immunologic studies on the induction of diabetes in experimental animals: Cellular basis for the induction of diabetes by streptozotocin
25. Treatment with anti-T-lymphocyte antibodies prevent induction of insulitis in mice given multiple doses of streptozotocin
26. Very low-dose streptozotocin induces diabetes in insulin-promoter-mB7-1 transgenic mice
27. Specific immunity to streptozotocin: Cellular requirement for induction of lymphoproliferation
28. T cell-dependent class II major histocompatibility complex antigen expression in vivo induced by the diabetogen streptozotocin
29. Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-γ
30. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin
31. Metallothionein in isolated pancreatic islets of mice: Induction by zinc and streptozotocin, a naturally occuring diabetogen
32. Procedures for cDNA cloning
33. Flow-cytometric detection of terminal deoxynucleotidyl transferase and other intracellular antigens in combination with membrane antigens in acute lymphatic leukemias
34. Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus
35. Administration of IL-4 prevents autoimmune diabetes but enhances pancreatic insulitis in NOD mice
36. Reduction in insulitis following administration of IFN-γ and TNF-α in the NOD mouse
37. The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse
38. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ
39. Local expression of transgene encoded TNF-α in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells
40. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice
41. Pancreatic IL-4 expression in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse
42. Transgenic expression of interleukin 10 in the pancreas renders resistant mice susceptible to low dose streptozotocin-induced diabetes
43. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β cells in nonbese diabetic mice
44. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity
45. 2
46. Increased production of interferon-gamma, but not IL-4 mRNA by streptozotocin in the popliteal lymphnode assay
47. Reactive oxygen species activate human peripheral blood dendritic cells
48. Cytokines and free radicals as effector molecules in the destruction of pancreatic β cells
49. Transcriptional regulation of Th1/Th2 polarization