Building skeletally diverse architectures on the Indoline Scaffold: The discovery of a chemical probe of focal adhesion kinase signaling networks

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9596-9602

  Prakesch, Michael ^b   Bijian, Krikor ^c   Campagna Slater, Valérie ^d   Quevillon, Sophie ^a   Joseph, Reni ^a   Wei, Chang Qing ^a   Sesmilo, Esther ^a   Reayi, Ayub ^a   Poondra, Rajamohan R ^a   Barnes, Michael L ^a   Leek, Donald M ^a   Xu, Bin ^c   Lougheed, Caroline ^c   Schapira, Matthieu ^d,e   Alaoui Jamali, Moulay ^c   Arya, Prabhat ^a,b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Anti cancer agents; Cell migration; Diversity oriented synthesis; Docking; Focal adhesion kinase; Natural product like compounds; Natural products; Signaling networks; Small molecule chemical probes

Indexed keywords

ACTIN; ALKALOID DERIVATIVE; FOCAL ADHESION KINASE; INDOLE DERIVATIVE; NATURAL PRODUCT;

ARTICLE; CELL INVASION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WOUND HEALING;

BREAST NEOPLASMS; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; COMPUTER SIMULATION; ENZYME INHIBITORS; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INDOLE ALKALOIDS; INDOLES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; WOUND HEALING;

EID: 53949110778     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.025     Document Type: Article

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