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Volumn 103, Issue 5, 2008, Pages 389-396

Epigenetic changes in cancer as potential targets for prophylaxis and maintenance therapy

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYLSULFAMOYLCINNAMOHYDROXAMIC ACID; 5 AZA 2' DEOXYCYTIDINE; 5 AZACYTIDINE PHOSPHATE GUANOSINE; ADENOSYLHOMOCYSTEINASE INHIBITOR; AZACITIDINE; BELINOSTAT; BUTYRIC ACID; DEAZANE PLANOCIN A; DNA; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE INHIBITOR; DZNEP; HISTONE; HISTONE DEACETYLASE INHIBITOR; MG 98; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N (2 AMINOPHENYL) 4 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINOMETHYL]BENZAMIDE; NICOTINAMIDE; PANOBINOSTAT; POLYAMINE DERIVATIVE; RG 108; ROMIDEPSIN; S 110; SIRTUIN; SPLITOMICIN; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; ZEBULARINE;

EID: 53949084470     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2008.00325.x     Document Type: Short Survey
Times cited : (26)

References (62)
  • 2
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999 99 : 247 57.
    • (1999) Cell , vol.99 , pp. 247-57
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 3
    • 0037133565 scopus 로고    scopus 로고
    • Comprehensive analysis of CpG islands in human chromosomes 21 and 22
    • Takai D, Jones PA. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci USA 2002 99 : 3740 5.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3740-5
    • Takai, D.1    Jones, P.A.2
  • 4
    • 0025145277 scopus 로고
    • 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes
    • Rideout WM III, Coetzee GA, Olumi AF, Jones PA. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 1990 249 : 1288 90.
    • (1990) Science , vol.249 , pp. 1288-90
    • Rideout III, W.M.1    Coetzee, G.A.2    Olumi, A.F.3    Jones, P.A.4
  • 5
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 2007 447 : 425 32.
    • (2007) Nature , vol.447 , pp. 425-32
    • Reik, W.1
  • 6
    • 0342437491 scopus 로고    scopus 로고
    • MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
    • Nan X, Campoy FJ, Bird A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 1997 88 : 471 81.
    • (1997) Cell , vol.88 , pp. 471-81
    • Nan, X.1    Campoy, F.J.2    Bird, A.3
  • 8
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002 3 : 415 28.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-28
    • Jones, P.A.1    Baylin, S.B.2
  • 9
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 2001 410 : 116 20.
    • (2001) Nature , vol.410 , pp. 116-20
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3    Mechtler, K.4    Jenuwein, T.5
  • 11
    • 15744396813 scopus 로고    scopus 로고
    • The key to development: Interpreting the histone code?
    • Margueron R, Trojer P, Reinberg D. The key to development: interpreting the histone code? Curr Opin Genet Dev 2005 15 : 163 76.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 163-76
    • Margueron, R.1    Trojer, P.2    Reinberg, D.3
  • 12
    • 43249102851 scopus 로고    scopus 로고
    • Erasing the methyl mark: Histone demethylases at the center of cellular differentiation and disease
    • Cloos PA, Christensen J, Agger K, Helin K. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 2008 22 : 1115 40.
    • (2008) Genes Dev , vol.22 , pp. 1115-40
    • Cloos, P.A.1    Christensen, J.2    Agger, K.3    Helin, K.4
  • 13
    • 33745632390 scopus 로고    scopus 로고
    • The epigenetic magic of histone lysine methylation
    • Jenuwein T. The epigenetic magic of histone lysine methylation. FEBS J 2006 273 : 3121 35.
    • (2006) FEBS J , vol.273 , pp. 3121-35
    • Jenuwein, T.1
  • 14
    • 35349006314 scopus 로고    scopus 로고
    • Histone lysine demethylases: Emerging roles in development, physiology and disease
    • Shi Y. Histone lysine demethylases: emerging roles in development, physiology and disease. Nat Rev Genet 2007 8 : 829 33.
    • (2007) Nat Rev Genet , vol.8 , pp. 829-33
    • Shi, Y.1
  • 15
    • 2342475666 scopus 로고    scopus 로고
    • Polycomb complexes and silencing mechanisms
    • Lund AH, van LM. Polycomb complexes and silencing mechanisms. Curr Opin Cell Biol 2004 16 : 239 46.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 239-46
    • Lund, A.H.1    Van, L.M.2
  • 16
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 2006 24 : 268 73.
    • (2006) J Clin Oncol , vol.24 , pp. 268-73
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3    Stefansson, I.M.4    Straume, O.5    Haukaas, S.A.6
  • 17
    • 36349017912 scopus 로고    scopus 로고
    • A polycomb repression signature in metastatic prostate cancer predicts cancer outcome
    • Yu J, Yu J, Rhodes DR, Tomlins SA, Cao X, Chen G et al. A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. Cancer Res 2007 67 : 10657 63.
    • (2007) Cancer Res , vol.67 , pp. 10657-63
    • Yu, J.1    Yu, J.2    Rhodes, D.R.3    Tomlins, S.A.4    Cao, X.5    Chen, G.6
  • 18
    • 34447552591 scopus 로고    scopus 로고
    • Quantitative gene expression deregulation in mantle-cell lymphoma: Correlation with clinical and biologic factors
    • Kienle D, Katzenberger T, Ott G, Saupe D, Benner A, Kohlhammer H et al. Quantitative gene expression deregulation in mantle-cell lymphoma: correlation with clinical and biologic factors. J Clin Oncol 2007 25 : 2770 7.
    • (2007) J Clin Oncol , vol.25 , pp. 2770-7
    • Kienle, D.1    Katzenberger, T.2    Ott, G.3    Saupe, D.4    Benner, A.5    Kohlhammer, H.6
  • 20
    • 33846569960 scopus 로고    scopus 로고
    • A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007 39 : 237 42.
    • (2007) Nat Genet , vol.39 , pp. 237-42
    • Ohm, J.E.1    McGarvey, K.M.2    Yu, X.3    Cheng, L.4    Schuebel, K.E.5    Cope, L.6
  • 21
    • 33846649587 scopus 로고    scopus 로고
    • Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
    • Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J et al. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 2007 39 : 232 6.
    • (2007) Nat Genet , vol.39 , pp. 232-6
    • Schlesinger, Y.1    Straussman, R.2    Keshet, I.3    Farkash, S.4    Hecht, M.5    Zimmerman, J.6
  • 22
    • 32844459336 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 directly controls DNA methylation
    • Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C et al. The polycomb group protein EZH2 directly controls DNA methylation. Nature 2006 439 : 871 4.
    • (2006) Nature , vol.439 , pp. 871-4
    • Vire, E.1    Brenner, C.2    Deplus, R.3    Blanchon, L.4    Fraga, M.5    Didelot, C.6
  • 23
    • 34347233479 scopus 로고    scopus 로고
    • DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2
    • McGarvey KM, Greene E, Fahrner JA, Jenuwein T, Baylin SB. DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res 2007 67 : 5097 102.
    • (2007) Cancer Res , vol.67 , pp. 5097-102
    • McGarvey, K.M.1    Greene, E.2    Fahrner, J.A.3    Jenuwein, T.4    Baylin, S.B.5
  • 24
    • 44349131472 scopus 로고    scopus 로고
    • Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    • Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, Charo C et al. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet 2008 40 : 741 50.
    • (2008) Nat Genet , vol.40 , pp. 741-50
    • Kondo, Y.1    Shen, L.2    Cheng, A.S.3    Ahmed, S.4    Boumber, Y.5    Charo, C.6
  • 25
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980 20 : 85 93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 26
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004 429 : 457 63.
    • (2004) Nature , vol.429 , pp. 457-63
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 27
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the cancer and leukemia Group B
    • Silverman LR, McKenzie DR, Peterson BL, Holland JF, Backstrom JT, Beach CL et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the cancer and leukemia Group B. J Clin Oncol 2006 24 : 3895 903.
    • (2006) J Clin Oncol , vol.24 , pp. 3895-903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3    Holland, J.F.4    Backstrom, J.T.5    Beach, C.L.6
  • 28
    • 0037108309 scopus 로고    scopus 로고
    • Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment
    • Daskalakis M, Nguyen TT, Nguyen C, Guldberg P, Köhler G, Wijermans P et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment. Blood 2002 100 : 2957 64.
    • (2002) Blood , vol.100 , pp. 2957-64
    • Daskalakis, M.1    Nguyen, T.T.2    Nguyen, C.3    Guldberg, P.4    Köhler, G.5    Wijermans, P.6
  • 29
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa JP, Garcia-Manero G, Giles FJ, Mannari R, Thomas D, Faderl S et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004 103 : 1635 40.
    • (2004) Blood , vol.103 , pp. 1635-40
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3    Mannari, R.4    Thomas, D.5    Faderl, S.6
  • 30
    • 29144473297 scopus 로고    scopus 로고
    • An epigenetic approach to the treatment of advanced MDS; The experience with the DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine) in 177 patients
    • Wijermans PW, Lubbert M, Verhoef G, Klimek V, Bosly A. An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine) in 177 patients. Ann Hematol 2005 84 : 9 17.
    • (2005) Ann Hematol , vol.84 , pp. 9-17
    • Wijermans, P.W.1    Lubbert, M.2    Verhoef, G.3    Klimek, V.4    Bosly, A.5
  • 31
    • 42049096709 scopus 로고    scopus 로고
    • Azacitidine (AZA) treatment prolongs overall survival (OS) in higher-risk MDS patients compared with conventional care regimens (CCR): Results of the AZA-001 phase III study
    • Fenaux P, Mufti GJ, Santini V, Finelli C, Giagounidis A, Schoch R et al. Azacitidine (AZA) treatment prolongs overall survival (OS) in higher-risk MDS patients compared with conventional care regimens (CCR): results of the AZA-001 phase III study. ASH Annual Meeting Abstracts 2007 110 : 817.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 817
    • Fenaux, P.1    Mufti, G.J.2    Santini, V.3    Finelli, C.4    Giagounidis, A.5    Schoch, R.6
  • 34
    • 33746228121 scopus 로고    scopus 로고
    • Sirtuins in aging and age-related disease
    • Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell 2006 126 : 257 68.
    • (2006) Cell , vol.126 , pp. 257-68
    • Longo, V.D.1    Kennedy, B.K.2
  • 35
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006 6 : 38 51.
    • (2006) Nat Rev Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 36
    • 33845996135 scopus 로고    scopus 로고
    • Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
    • Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007 109 : 31 9.
    • (2007) Blood , vol.109 , pp. 31-9
    • Duvic, M.1    Talpur, R.2    Ni, X.3    Zhang, C.4    Hazarika, P.5    Kelly, C.6
  • 37
    • 28044463368 scopus 로고    scopus 로고
    • Clinical translation of epigenetics in cancer: EN-CORe - A report on the second workshop
    • Zelent A, Petrie K, Lotan R, Waxman S, Gore SD. Clinical translation of epigenetics in cancer: eN-CORe - a report on the second workshop. Mol Cancer Ther 2005 4 : 1810 9.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1810-9
    • Zelent, A.1    Petrie, K.2    Lotan, R.3    Waxman, S.4    Gore, S.D.5
  • 38
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore SD, Baylin S, Sugar E, Carraway H, Miller CB, Carducci M et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006 66 : 6361 9.
    • (2006) Cancer Res , vol.66 , pp. 6361-9
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3    Carraway, H.4    Miller, C.B.5    Carducci, M.6
  • 39
    • 33645768490 scopus 로고    scopus 로고
    • Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
    • Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2006 2 : e40.
    • (2006) PLoS Genet , vol.2
    • Pruitt, K.1    Zinn, R.L.2    Ohm, J.E.3    McGarvey, K.M.4    Kang, S.H.5    Watkins, D.N.6
  • 40
    • 34948899771 scopus 로고    scopus 로고
    • Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level
    • Qiu J, Huang Y, Chen G, Chen Z, Tweardy DJ, Dong S. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell 2007 18 : 3941 51.
    • (2007) Mol Biol Cell , vol.18 , pp. 3941-51
    • Qiu, J.1    Huang, Y.2    Chen, G.3    Chen, Z.4    Tweardy, D.J.5    Dong, S.6
  • 41
    • 33748997409 scopus 로고    scopus 로고
    • Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia
    • Cimino G, Lo-Coco F, Fenu S, Travaglini L, Finolezzi E, Mancini M et al. Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia. Cancer Res 2006 66 : 8903 11.
    • (2006) Cancer Res , vol.66 , pp. 8903-11
    • Cimino, G.1    Lo-Coco, F.2    Fenu, S.3    Travaglini, L.4    Finolezzi, E.5    Mancini, M.6
  • 42
    • 53949093111 scopus 로고    scopus 로고
    • Maintenance treatment with azacytidine for patients with high risk myelodysplastic syndromes or acute myeloid leukaemia in complete remission after intensive chemotherapy
    • Grövdal M, Khan R, Aggerholm A, Antunovic P, Astermark J, Bernell P et al. Maintenance treatment with azacytidine for patients with high risk myelodysplastic syndromes or acute myeloid leukaemia in complete remission after intensive chemotherapy. ASH Annual Meeting Abstracts 2007 110 : 818.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 818
    • Grövdal, M.1    Khan, R.2    Aggerholm, A.3    Antunovic, P.4    Astermark, J.5    Bernell, P.6
  • 43
    • 31544432335 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells
    • Earel JK Jr., VanOosten RL, Griffith TS. Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells. Cancer Res 2006 66 : 499 507.
    • (2006) Cancer Res , vol.66 , pp. 499-507
    • Earel Jr., J.K.1    Vanoosten, R.L.2    Griffith, T.S.3
  • 44
    • 20844435806 scopus 로고    scopus 로고
    • Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
    • Hideshima T, Bradner JE, Wong J, Chauhan D, Richardson P, Schreiber SL et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci USA 2005 102 : 8567 72.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8567-72
    • Hideshima, T.1    Bradner, J.E.2    Wong, J.3    Chauhan, D.4    Richardson, P.5    Schreiber, S.L.6
  • 45
    • 33645226815 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells
    • Sonnemann J, Kumar KS, Heesch S, Muller C, Hartwig C, Maass M et al. Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. Int J Oncol 2006 28 : 755 66.
    • (2006) Int J Oncol , vol.28 , pp. 755-66
    • Sonnemann, J.1    Kumar, K.S.2    Heesch, S.3    Muller, C.4    Hartwig, C.5    Maass, M.6
  • 46
    • 33750303818 scopus 로고    scopus 로고
    • Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells
    • Fiskus W, Pranpat M, Balasis M, Bali P, Estrella V, Kumaraswamy S et al. Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin Cancer Res 2006 12 : 5869 78.
    • (2006) Clin Cancer Res , vol.12 , pp. 5869-78
    • Fiskus, W.1    Pranpat, M.2    Balasis, M.3    Bali, P.4    Estrella, V.5    Kumaraswamy, S.6
  • 47
    • 34447123203 scopus 로고    scopus 로고
    • Delivery of 5-aza-2′-deoxycytidine to cells using oligodeoxynucleotides
    • Yoo CB, Jeong S, Egger G, Liang G, Phiasivongsa P, Tang C et al. Delivery of 5-aza-2′-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res 2007 67 : 6400 8.
    • (2007) Cancer Res , vol.67 , pp. 6400-8
    • Yoo, C.B.1    Jeong, S.2    Egger, G.3    Liang, G.4    Phiasivongsa, P.5    Tang, C.6
  • 49
    • 27744561770 scopus 로고    scopus 로고
    • Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: Influence of sex and inhibitors
    • Klecker RW, Cysyk RL, Collins JM. Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors. Bioorg Med Chem 2006 14 : 62 6.
    • (2006) Bioorg Med Chem , vol.14 , pp. 62-6
    • Klecker, R.W.1    Cysyk, R.L.2    Collins, J.M.3
  • 50
    • 33846444355 scopus 로고    scopus 로고
    • Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2′-deoxycytidine treatment
    • Egger G, Aparicio AM, Escobar SG, Jones PA. Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2′- deoxycytidine treatment. Cancer Res 2007 67 : 346 53.
    • (2007) Cancer Res , vol.67 , pp. 346-53
    • Egger, G.1    Aparicio, A.M.2    Escobar, S.G.3    Jones, P.A.4
  • 51
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • Brueckner B, Boy RG, Siedlecki P, Musch T, Kliem HC, Zielenkiewicz P et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 2005 65 : 6305 11.
    • (2005) Cancer Res , vol.65 , pp. 6305-11
    • Brueckner, B.1    Boy, R.G.2    Siedlecki, P.3    Musch, T.4    Kliem, H.C.5    Zielenkiewicz, P.6
  • 52
    • 33646595937 scopus 로고    scopus 로고
    • Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: A National Cancer Institute of Canada Clinical Trials Group investigational new drug study
    • Winquist E, Knox J, Ayoub JP, Wood L, Wainman N, Reid GK et al. Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study. Invest New Drugs 2006 24 : 159 67.
    • (2006) Invest New Drugs , vol.24 , pp. 159-67
    • Winquist, E.1    Knox, J.2    Ayoub, J.P.3    Wood, L.4    Wainman, N.5    Reid, G.K.6
  • 53
    • 38949194522 scopus 로고    scopus 로고
    • Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy
    • Amato RJ. Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy. Clin Genitourin Cancer 2007 5 : 422 6.
    • (2007) Clin Genitourin Cancer , vol.5 , pp. 422-6
    • Amato, R.J.1
  • 54
    • 0036171225 scopus 로고    scopus 로고
    • Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2′-deoxycytidine
    • Liang G, Gonzales FA, Jones PA, Orntoft TF, Thykjaer T. Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2′-deoxycytidine. Cancer Res 2002 62 : 961 6.
    • (2002) Cancer Res , vol.62 , pp. 961-6
    • Liang, G.1    Gonzales, F.A.2    Jones, P.A.3    Orntoft, T.F.4    Thykjaer, T.5
  • 55
    • 53949120109 scopus 로고    scopus 로고
    • Cancer risk in long-term users of Valproate: A population-based case-control study
    • Hallas J, Friis S, Bjerrum L, Støvring H, Narverud SF, Heyerdahl T et al. Cancer risk in long-term users of Valproate: a population-based case-control study. APMIS 2008 116 : 440.
    • (2008) APMIS , vol.116 , pp. 440
    • Hallas, J.1    Friis, S.2    Bjerrum, L.3    Støvring, H.4    Narverud, S.F.5    Heyerdahl, T.6
  • 56
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL et al. Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 2007 21 : 1050 63.
    • (2007) Genes Dev , vol.21 , pp. 1050-63
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6
  • 57
    • 33846225576 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells
    • Fiskus W, Pranpat M, Balasis M, Herger B, Rao R, Chinnaiyan A et al. Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells. Mol Cancer Ther 2006 5 : 3096 104.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3096-104
    • Fiskus, W.1    Pranpat, M.2    Balasis, M.3    Herger, B.4    Rao, R.5    Chinnaiyan, A.6
  • 58
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004 119 : 941 53.
    • (2004) Cell , vol.119 , pp. 941-53
    • Shi, Y.1    Lan, F.2    Matson, C.3    Mulligan, P.4    Whetstine, J.R.5    Cole, P.A.6
  • 60
    • 34249934238 scopus 로고    scopus 로고
    • Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes
    • Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM et al. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci USA 2007 104 : 8023 8.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8023-8
    • Huang, Y.1    Greene, E.2    Murray Stewart, T.3    Goodwin, A.C.4    Baylin, S.B.5    Woster, P.M.6
  • 61
    • 43249116995 scopus 로고    scopus 로고
    • Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2
    • Pasini D, Hansen KH, Christensen J, Agger K, Cloos PA, Helin K. Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev 2008 22 : 1345 55.
    • (2008) Genes Dev , vol.22 , pp. 1345-55
    • Pasini, D.1    Hansen, K.H.2    Christensen, J.3    Agger, K.4    Cloos, P.A.5    Helin, K.6
  • 62
    • 0035522894 scopus 로고    scopus 로고
    • Two genetic hits (more or less) to cancer
    • Knudson AG. Two genetic hits (more or less) to cancer. Nat Rev Cancer 2001 1 : 157 62.
    • (2001) Nat Rev Cancer , vol.1 , pp. 157-62
    • Knudson, A.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.