Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: Comparison with conventional protein/enzyme methods

Drug and Chemical Toxicology

Volumn 31, Issue 4, 2008, Pages 501-513

  Wang, Er Jia ^a   Mandakas, George ^a   Palamanda, Jairam ^a   Lin, Xinjie ^a   Kumari, Pramila ^a   Chu, Inhou ^a   Soares, Anthony ^a   Smith, Roger J ^a   Snyder, Ronald D ^a   Gu, Yi Zhong ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Chemicals; CYP induction; Liver; Mice

Indexed keywords

BETA NAPHTHOFLAVONE; CLOFIBRATE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B10; CYTOCHROME P450 3A11; CYTOCHROME P450 4A10; DEXAMETHASONE; PHENOBARBITAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; INTERMETHOD COMPARISON; LIVER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RNA ANALYSIS; WESTERN BLOTTING;

ANIMALS; BETA-NAPHTHOFLAVONE; CLOFIBRATE; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DRUG EVALUATION, PRECLINICAL; ENZYME INDUCTION; FEASIBILITY STUDIES; ISOENZYMES; LIVER; MALE; MICE; PHENOBARBITAL; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

MUS; RODENTIA;

EID: 53849103268     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540802390825     Document Type: Article

References (20)

1. Adesnik, M., Atchison, M. (1985). Genes for cytochrome P-450 and their regulation. CRC Crit. Rev. Biochem. 19:247-305.
2. Afsharian, P., Terelius, Y., Hassan, Z., Nilsson, C., Lundgren, S., Hassan, M. (2007). The effect of repeated administration of cyclophosphamide on cytochrome P450 2B in rats. Clin. Cancer Res. 13:4218-4224.
3. Baldwin, S. J., Bramhall, J. L., Ashby, C. A., Yue, L., Murdock, P. R., Hood, S. R., Ayrton, A. D., Clarke, S. E. (2006). Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase polymerase chain reaction (TaqMan). Drug. Metab. Dispos. 34:1063-1069.
4. Godfrey, T. E., Kelly, L. A. (2005). Development of quantitative reverse transcriptase PCR assays for measuring gene expression. Meth. Mol. Biol. 291:423-445.
5. Goodsaid, F. M., Palamanda, J. R., Montgomery, D., Mandakas, G., Gu, C., Li, Z., You, X., Norton, L., Smith, R., Chu, I., et al. (2003). Assessment of temporal biochemical and gene transcription changes in rat liver cytochrome P450: utility of real-time quantitative RT-PCR. Pharm. Res. 20:1373-1380.
6. Guengerich, F. P. (1997). Role of cytochrome P450 enzymes in drug-drug interactions. Adv Pharmacol 43:7-35.
7. Huang, S. M., Lesko, L. J. (2004). Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions - what have we learned? J. Clin. Pharmacol. 44:559-569.
8. Itoh, K., Nakamura, K., Kimura, T., Itoh, S., Kamataki, T. (1997). Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). J. Toxicol. Sci. 22:45-56.
9. Martignoni, M., de Kanter, R., Grossi, P., Mahnke, A., Saturno, G., Monshouwer, M. (2004). An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR. Chem. Biol. Interact. 151:1-11.
10. Martignoni, M., de Kanter, R., Grossi, P., Saturno, G., Barbaria, E., Monshouwer, M. (2006). An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR. Toxicol. In Vitro. 20:125-131.
11. Nazarenko, D. A., Dertinger, S. D., Gasiewicz, T. A. (2001). In vivo antagonism of AhR-mediated gene induction by 3′-methoxy-4′- nitroflavone in TCDD-responsive lacZ mice. Toxicol. Sci. 61:256-264.
12. Nelson, D. R., Kamataki, T., Waxman, D. J., Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J., Gunsalus, I. C., Gotoh, O., Okuda, K., Nebert, D. W. (1993). The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell. Biol. 12:1-51.
13. Pan, J., Xiang, Q., Ball, S. (2000). Use of a novel real-time quantitative reverse transcription polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver. Drug Metab. Dispos. 28:709-713.
14. Pan, J., Xiang, Q., Renwick, A. B., Price, R. J., Ball, S. E., Kao, J., Scatina, J. A., Lake, B. G. (2002). Use a quantitative real-time reverse transcription polymerase chain reaction method to study the induction of CYP1A, CYP2B, and CYP4A forms in precision-cut rat liver slices. Xenobiotica 32:739-747.
15. Peterson, G. L. (1977). A simplification of the protein assay method of Lowry et al., which is more generally applicable. Anal. Biochem. 83:346-356.
16. Pustylnyak, V. O., Lebedev, A. N., Gulyaeva, L. F., Lyakhovich, V. V., Slynko, N. M. (2007). Comparative study of CYP2b induction in the liver of rats and mice by different compounds. Life Sci. 80:324-328
17. Sun, G., Thai, S. F., Tully, D. B., Lambert, G. R., Goetz, A. K., Wolf, D. C., Dix, D. J., Nesnow, S. (2005). Propiconazole-induced cytochrome P450 gene expression and enzymatic activities in rat and mouse liver. Toxicol. Lett. 155:277-287.
18. Szwaya, J., Bruseo, C., Nakuci, E., McSweeney, D., Xiang, X., Senator, D., France, D., Chen, C. R. (2007). A novel platform for accelerated pharmacodynamic profiling for lead optimization of anticancer drug candidates. J. Biomol. Screen. 12:159-166.
19. Xie, H., Afsharian, P., Terelius, Y., Mirghani, R. A., Yasar, U., Hagbjörk, A. L., Lundgren, S., Hu, Y., Rane, A., Hassan, M. (2005). Cyclophosphamide induces mRNA, protein, and enzyme activity of cytochrome P450 in rat. Xenobiotica 35:239-251.
20. Xu, C., Li, C. Y., Kong, A. N. (2005). Induction of phase I, II, and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res. 28:249-268.