In vivo antagonism of AhR-mediated gene induction by 3′-methoxy-4′-nitroflavone in TCDD-responsive lacZ mice

Toxicological Sciences

Volumn 61, Issue 2, 2001, Pages 256-264

  Nazarenko, Daniel A ^a   Dertinger, Stephen D ^a,b   Gasiewicz, Thomas A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b LITRON LABORATORIES   (United States)

Author keywords

3 methoxy 4 nitroflavone (3 M4 NF); Aryl hydrocarbon receptor (AhR); Receptor antagonism; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3' METHOXY 4' NITROFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BETA GALACTOSIDASE; CYTOCHROME P450 1A1; FLAVONE DERIVATIVE; LIGAND; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DRUG EFFICACY; DRUG INHIBITION; ENZYME INDUCTION; EXPOSURE; GENE ACTIVATION; GENE INDUCTION; IMMUNOTOXICITY; IN VIVO STUDY; LUNG; MALE; MODULATION; MOUSE; NONHUMAN; PROTEIN FAMILY; REPORTER GENE; REPRODUCTIVE TOXICITY; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ANIMALS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FLAVONOIDS; GENE EXPRESSION REGULATION; GENES, REPORTER; LAC OPERON; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ARYL HYDROCARBON; TETRACHLORODIBENZODIOXIN; TIME FACTORS;

ANIMALIA; MUS MUSCULUS;

EID: 0034981115     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/61.2.256     Document Type: Article

References (50)

1. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters embryonic palatal medial epithelial cell differentiation in vitro
2. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse
3. Biochemical basis of enhanced drug bioavailability by piperine: Evidence that piperine is a potent inhibitor of drug metabolism
4. 2,2′,4,4′,5,5′-Hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice
5. α-Naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced murine lymphocyte ethoxyresorufin-O-deethylase activity and immunosuppression
6. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) accelerates differentiation of murine preimplantation embryos in vitro
7. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo
8. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: Implications for prevention of dioxin toxicity
9. Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex
10. Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor
11. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol
12. Effect of 3′-methoxy-4′ nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms
13. Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo
14. Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric
15. Lesions of aryl-hydrocarbon receptor-deficient mice
16. Characterization of multiple forms of the Ah receptor: Recognition of a dioxin-responsive enhancer involves heteromer formation
17. Analysis of structural requirements for Ah receptor antagonist activity: Ellipticines, flavones, and related compounds
18. Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8- tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor
19. Selective estrogen receptor modulators (SERMs)
20. Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: Mechanistic studies
21. Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin
22. Flavone antagonists bind competitively with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation
23. Nuclear localization and export signals of the human aryl hydrocarbon receptor
24. Structure-activity relationships of estrogens
25. Distinguishing androgen receptor agonists and antagonists: Distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone
26. Inhibition of Ah (dioxin) receptor transformation by 9-hydroxy ellipticine. Involvement of protein kinase C?
27. Ahr null alleles: Distinctive or different?
28. Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice
29. Development of antiestrogens and their use in breast cancer
30. 6-Substituted 3,4-benzocoumarins: A new structural class of inducers and inhibitors of CYP1A1-dependent activity
31. Identification of 3′-methoxy-4′-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells
32. Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists
33. 2,3,7,8-Tetachlorodibenzo-p-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene
34. Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor
35. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
36. The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression
37. Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells
38. Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression
39. Estrogen receptor subtype-selective ligands: Asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl-5,6,11,12-tetrahydrochrysenes
40. Enhanced Detection of β-galactosidase reporter activation by a luminescent assay in tissue lysates is achieved by a reduction of hemoglobin content
41. Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
42. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy
43. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
44. α-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation
45. Rational discovery of novel nuclear hormone receptor antagonists
46. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta
47. Effects of ciprofloxacin and enrofloxacin on zoxazolamine kinetics, plasma concentration, and sleeping times in mice
48. Response of [Ah] battery genes to compounds that protect against menadione toxicity
49. Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice
50. Selective inactivation of eukaryotic beta-galactosidase in assays for inhibitors of HIV-1 TAT using bacterial beta-galactosidase as a reporter enzyme